Continuous evolution of HIV-1 more than ten years after infection in an elite neutralizer

International audienc

Hepatitis C virus drives increased type I interferon-associated impairments associated with fibrosis severity in antiretroviral treatment-treated HIV-1-hepatitis C virus-coinfected individuals

International audienceOn behalf of the HepACT-VIH study group - Viral coinfections might contribute to the increased immune activation and inflammation that persist in antiretroviral treatment (ART)-treated HIV-1 patients. We investigated whether the hepatitis C virus (HCV) coinfection contributes to such alterations by impairing the plasmacytoid dendritic cell (pDC) IFNa/TLR7 pathway in a highly homogeneous group of ART-treated HIV-1-HCV-coinfected patients