Rainwater Harvesting and Its Impact on Farming Systems

Landless, small holders and other poors supplement their livelihood and adapt to climate change by grazing, stall feeding with crop residues and fodder cultivated under rainfed and irrigated conditions. Improving productivity by conserving rainfall, ground water recharging, harvesting and recycling of rainwater especially in degraded open access or shared land with community participation was quite successful over a wide range of precipitation and ecological situations. Various types of trenches, bunding, vegetative barriers, gully plugs, ponds, check dams, land slides and mine spoils stabilization etc. retained more soil moisture, seeds, vegetative propagules etc. in situ and prevented soil erosion. It regenerated and enhanced biomass production of grasses, other forages, crop residues and environmental externalities. It reduced socially undesirable seasonal migration of herders by 35-100%, number of goats, dependency on open or common access resources and increased bovine population, stall feeding and milk productivity. Limited irrigation with harvested and recharged rainwater led to farm diversification, more availability of crop residues and better income. Climate change has reduced number of rainy days, increased intensity and frequency of run off producing events and can be converted into still better opportunities of adaptation by rain water harvesting

The Role of Precedent in Defining Res Judicata in Investor–State Arbitration

As international arbitration, and investment arbitration in particular, becomes more prevalent, the risks of doctrinal fragmentation also increase, in part driven by the disparate treatment of the doctrine of res judicata throughout most jurisdictions, and in the arbitration context. Notwithstanding the general consensus regarding the broad contours of res judicata and its firm position as a principle of international law, there is little agreement regarding how it is to be administered. These developments threaten to undermine the international arbitration system, wresting from it normative legitimacy. The U.S. common law version of res judicata, which is distinct from res judicata as developed in many civil law jurisdictions, may serve as a substantial conceptual foundation upon which civil law and other common law res judicata precepts may merge to fashion a uniform doctrine applicable in international arbitration that is expansive, substantive/transactional-based as to criteria, and non-formalistic in its application so as to avert and discourage the doctrine’s circumvention through the use of legal fictions

Catatonia with GABAA receptor antibodies

A 22-year-old African woman developed acute behavioural change, against a background of sickle cell disease with strokes requiring a ventriculoperitoneal shunt. She alternated between mutism with prolonged staring and posturing, and a state of agitation with elation and echolalia. Cerebrospinal fluid (CSF) protein was elevated and electroencephalogram showed mild slowing with bitemporal slow and sharp waves. We suspected catatonia secondary to possible autoimmune encephalitis but her condition persisted despite intravenous methylprednisolone. After identifying a positive serum anti-gamma-aminobutyric acid-A (GABAA) antibody, treatment with intravenous immunoglobulin, oral corticosteroids and rituximab led to gradual improvement. Patients with catatonia may show reduced GABAA receptor density and there are two other reports of catatonia with anti-GABAA antibodies. This patient's treatment response supports the antibody's causative role

Synthesis of Selective CDK2/SPY1 Inhibitors employing Stereochemical Control - An invaluable tool in an Organic Chemist’s belt

The cell cycle of a healthy eukaryotic cell depends on the efficiency of cyclin-dependent kinase (CDKs) checkmarks, to ensure normal cell proliferation. CDK2 is responsible for progression of cells into the S and M phases, and it is critical to the abnormal growth processes of cancer cells. Examination of different kinds of human cancers, for their vulnerability to CDK2 inhibition, has revealed CDK2 as a good therapeutic target. In the past two decades, various CDK2 inhibitors have been designed but have stumbled on the roadblock of selectivity issue, since CDK2 shares 74 and 68% sequence identity and active sites with its family members’ CDK3 and CDK1, respectively. Moreover, it’s not CDK2 alone that needs to be targeted but the activated complex it forms with Spy1, a protein that can activate CDK2 in the same way as cyclin but is highly upregulated in cancer cells. After extensive computational studies, we found some unique yet challenging CDK2/SPY1 inhibitors. In this presentation, I will discuss the importance of stereochemical control in the design and synthesis of novel and selective CDK2/SPY1 inhibitors. The synthesis ensures that the inhibitors are stereochemically pure, and thus the biological activity can be accurately evaluated. These results can then be used to refine our computational models to further improve the selectivity of our drug candidates

Synthesis and Characterization of ZnO-MMT Nanocomposite for Antibacterial Activity Studies

ZnO oxide Nanoparticle and ZnO oxide with Montmorillonite nanocomposite were prepared by an environmentally friendly, efficient, and  inexpensive method that was synthesized using the chemical method. ZnO nanoparticles as an effective antibacterial material were immobilized on the surface of montmorillonite (MMT). The objectives of this paper are to summarize our research activities in (a) developing processes to dispersenanomaterials (undoped and doped zinc oxide powders) in the polymers matrix, (b) using X-ray diffraction (XRD), Fourier Transform Infra-Red Spectroscopy (FT-IR), Scanning Electron Microscopy (SEM) and Thermo Gravimetric Analysis (TGA) techniques to characterize polymer matrix structures, (c) studying structure-property relationship of these types of new materials, and (d) evaluating the antibacterial performance of these materials for different applications. The results showed that the ZnO nanocomposite was uniformly dispersed in the polymer matrix and the particles remained their average size (20 - 150 nm) before incorporation into the polymer matrix. Keywords: Zinc Oxide nanoparticle, Montmorillonite, FTIR, Antibacterial activit

On the shock behaviour and response of Ovis Aries vertebrae

When investigating a biological system during shock loading, it is best practice to isolate different components to fully comprehend each individual part [1,2] before building up the system as a whole. Due to the high acoustic impedance of bone in comparison to other biological tissues [3] the majority of the shock will be transmitted into this medium, and as such can cause large amounts of damage to other parts of the body potentially away from the impact area

Drug Discovery: Towards the Synthesis of Novel CDK2-Spy1 Inhibitors

As vital regulatory proteins in the cell cycle, cyclin-dependent kinases (CDKs) and cyclins ensure normal cell division and growth by monitoring check points in the cell cycle. CDKs are inactive on its own, but when a cyclin binds to CDK the activated CDK-Cyclin complexes then carry out their role as cell cycle regulators. Unregulated CDK-Cyclin complexes cause cells to grow and divide at a premature stage, and that can lead to uncontrolled cell growth. Existing treatments such as CKI (cyclin-dependent kinase inhibitor) therapy have cytotoxicity issues because of their inability to differentiate cancer cells from healthy cells, resulting in unwanted side effects. Our collaborators in the Porter Lab have identified a new target: CDK2-Spy1 complex. Spy proteins are alternative activators to CDKs in cancer cells, but not in healthy cells, making them an ideal therapeutic target. Notably, the Spy1 gene is among the top 50 genes associated with carcinoma, yet the CDK2-Spy1 complex has never been selectively targeted before in terms of CKI therapy. We therefore aim to synthesize molecules that selectively target CDK2-Spy1 complexes to develop a chemotherapy that has minimal cytotoxicity issues. In this presentation I will discuss our current progress towards small molecule inhibitors that show promising selectivity for CDK2-Spy1 complexes based on computational studies. Our synthetic routes and the analytical techniques employed to characterise these compounds will be described