Glycans in nanomedicine, impact and perspectives

Glycans have been selected by nature for both structural and 'recognition' purposes. Taking inspiration from nature, nanomedicine exploits glycans not only as structural constituents of nanoparticles and nanostructured biomaterials but also as selective interactors of such glyco-nanotools. Surface glycosylation of nanoparticles finds application in targeting specific cells, whereas recent findings give evidence that the glycan content of cell microenvironment is able to induce the cell fate. This review will highlight the role of glycans in nanomedicine, schematizing the different uses and roles in drug-delivery systems and in biomaterials for regenerative medicine

A new one-pot synthesis of quinoline-2-carboxylates under heterogeneous conditions

Quinoline-2-carboxylates are an important subclass of quinoline derivatives largely present in a variety of biologically active molecules, as well as useful ligands in metal-catalyzed reactions. Herein, we present a new one-pot protocol for synthesizing this class of derivatives starting from beta-nitroacrylates and 2-aminobenzaldehydes. In order to optimize the protocol, we investigated several reaction conditions, obtaining the best results using the 2-tert-butylimino-2-diethylamino- 1,3-dimethylperhydro-1,3,2-diazaphosphorine (BEMP) as solid base, in acetonitrile. Finally, we demonstrated the generality of our approach over several substrates which led to synthesize a plethora of functionalized quinolines-2-carboxylate derivatives in good overall yields

3D Extracellular Matrix Mimics: Fundamental Concepts and Role of Materials Chemistry to Influence Stem Cell Fate

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Nitroaldol (Henry) reaction of 2-oxoaldehydes with nitroalkanes as a strategic step for a useful, one-pot synthesis of 1,2-diketones

The nitroaldol (Henry) reaction of 2-oxoaldehydes with a variety of nitroalkanes, under basic heterogeneous conditions and microwave irradiation, affords 1,2-diketones in a one-pot way

A New Synthesis of Polyfunctionalized 2-Alkyl-1,4-diketones

The reactivity of silyl enol ethers with β-nitroenones was successfully exploited for synthesizing functionalized polycarbonyl frameworks, in very short reaction times and in good yields

Two-Step Synthesis of Polysubstituted 6-Nitroindoles under Flow Chemical and Microwave Conditions

A new simple and efficient synthesis of 6-nitroindoles, starting from N-carboxylalkylpyrrole-2-carboxaldehydes and protected beta-nitro ketones, has been developed. The method involves two distinct domino processes, respectively performed under flow chemical conditions and microwave irradiation. 6-Nitroindoles were produced in good to excellent overall yields

Synthesis of β-Nitro Ketones by Chemoselective Reduction of β-Nitro Enones under Solid Heterogeneous Catalysis

A new, simple and efficient chemoselective reduction of β-nitro enones to provide substituted β-nitro ketones, a strategic class of compounds, under solid heterogeneous palladium catalysis and in the presence of triethylsilane is presented. © Georg Thieme Verlag Stuttgart. New York

A new fully heterogeneous synthesis of pyrrole-2-acetic acid derivatives

Herein, we present a new general and efficient protocol to synthesize pyrrole-2-acetic acid derivatives starting from pyrroles and b-nitroacrylates, under fully heterogeneous condition