3D physical modeling of tsunamis generated by submerged landslides at a conical island. The role of initial acceleration

This paper presents a new set of 3D experiments aimed to gain insight on the role of the initial acceleration upon the generation process of tsunamis by submerged landslides that may occur at the flanks of conical islands. The experiments have been carried out in a large wave tank by varying the initial acceleration of the landslide model. A novel system, relying on the use of a computer controlled stepped motor, has been employed to control the motion of the landslide model. The experiments have been carried out in a parametric way by changing the initial acceleration of the landslide, aiming to reproduce different triggering mechanisms. Preliminary experimental findings confirmed the crucial role of the initial acceleration of the submerged landslide in generating tsunamis

Epiluminescence microscopy for the diagnosis of doubtful melanocytic skin lesions: Comparison of the ABCD rule of dermatoscopy and a new 7-point checklist based on pattern analysis

Objective: To compare the reliability of a new 7-point checklist based on simplified epiluminescence microscopy (ELM) pattern analysis with the ABCD rule of dermatoscopy and standard pattern analysis for the diagnosis of clinically doubtful melanocytic skin lesions. Design: In a blind study, ELM images of 342 histologically proven melanocytic skin lesions were evaluated for the presence of 7 standard criteria that we called the 'ELM 7-point checklist.' For each lesion, 'overall' and 'ABCD scored' diagnoses were recorded. From a training set of 57 melanomas and 139 atypical non-melanomas, odds ratios were calculated to create a simple diagnostic model based on identification of major and minor criteria for the '7-point scored' diagnosis. A test set of 60 melanomas and 86 atypical non-melanomas was used for model validation and was then presented to 2 less experienced ELM observers, who recorded the ABCD and 7-point scored diagnoses. Settings: University medical centers. Patients: A sample of patients with excised melanocytic lesions. Main Outcome Measures: Sensitivity, specificity, and accuracy of the models for diagnosing melanoma. Results: From the total combined sets, the 7-point checklist gave a sensitivity of 95% and a specificity of 75% compared with 85% sensitivity and 66% specificity using the ABCD rule and 91% sensitivity and 90% specificity using standard pattern analysis (overall ELM diagnosis). Compared with the ABCD rule, the 7-point method allowed less experienced observers to obtain higher diagnostic accuracy values. Conclusions: The ELM 7-point checklist provides a simplification of standard pattern analysis because of the low number of features to identify and the scoring diagnostic system. As with the ABCD rule, it can be easily learned and easily applied and has proven to be reliable in diagnosing melanoma

Thermocapillary actuation of liquid flow on chemically patterned surfaces

We have investigated the thermocapillary flow of a Newtonian liquid on hydrophilic microstripes which are lithographically defined on a hydrophobic surface. The speed of the microstreams is studied as a function of the stripe width w, the applied thermal gradient |dT/dx| and the liquid volume V deposited on a connecting reservoir pad. Numerical solutions of the flow speed as a function of downstream position show excellent agreement with experiment. The only adjustable parameter is the inlet film height, which is controlled by the ratio of the reservoir pressure to the shear stress applied to the liquid stream. In the limiting cases where this ratio is either much smaller or much larger than unity, the rivulet speed shows a power law dependency on w, |dT/dx| and V. In this study we demonstrate that thermocapillary driven flow on chemically patterned surfaces can provide an elegant and tunable method for the transport of ultrasmall liquid volumes in emerging microfluidic technologies

Has VZV epidemiology changed in Italy? Results of a seroprevalence study

The aim of the study was to evaluate if and how varicella prevalence has changed in Italy. In particular a seroprevalence study was performed, comparing it to similar surveys conducted in pre-immunization era. During 2013–2014, sera obtained from blood samples taken for diagnostic purposes or routine investigations were collected in collaboration with at least one laboratory/center for each region, following the approval of the Ethics Committee. Data were stratified by sex and age. All samples were processed in a national reference laboratory by an immunoassay with high sensitivity and specificity. Statutory notifications, national hospital discharge database and mortality data related to VZV infection were analyzed as well. A total of 3707 sera were collected and tested. In the studied period both incidence and hospitalization rates decreased and about 5 deaths per year have been registered. The seroprevalence decreased in the first year of life in subjects passively protected by their mother, followed by an increase in the following age classes. The overall antibody prevalence was 84%. The comparison with surveys conducted with the same methodology in 1996–1997 and 2003–2004 showed significant differences in age groups 1–19 y. The study confirms that in Italy VZV infection typically occurs in children. The impact of varicella on Italian population is changing. The comparison between studies performed in different periods shows a significant increase of seropositivity in age class 1–4 years, expression of vaccine interventions already adopted in some regions

Thrombosed external haemorrhoids: A clinician’s dilemma

Haemorrhoids are highly vascular submucosal cushions that underlie the distal rectal mucosa and contribute approximately 15-20% of the resting anal pressure, ensuring complete closure of the anal cana

Therapeutic Targets and Tumor Microenvironment in Colorectal Cancer

Colorectal cancer (CRC) is a genetically, anatomically, and transcriptionally heterogeneous disease. The prognosis for a CRC patient depends on the stage of the tumor at diagnosis and widely differs accordingly. The tumor microenvironment (TME) in CRC is an important factor affecting targeted cancer therapy. The TME has a dynamic composition including various cell types, such as cancer-associated fibroblasts, tumor-associated macrophages, regulatory T cells, and myeloid-derived suppressor cells, as well as extracellular factors that surround cancer cells and have functional and structural roles under physiological and pathological conditions. Moreover, the TME can limit the efficacy of therapeutic agents through high interstitial pressure, fibrosis, and the degradation of the therapeutic agents by enzymatic activity. For this reason, the TME is a fertile ground for the discovery of new drugs. The aim of this narrative review is to present current knowledge and future perspectives regarding the TME composition based on strategies for patients with CRC

Ambient noise tomography reveals basalt and sub-basalt velocity structure beneath the Faroe Islands, North Atlantic

The Faroe Islands Passive Seismological Experiment (FIPSE) was funded by Sindri (contract C46-52-01) and formed a collaborative project between Dr. David Cornwell, Prof. Richard England (University of Leicester) and Prof. Graham Stuart (University of Leeds). Seismological equipment was loaned from the NERC geophysical equipment facility (GEF, loan 918), with field assistance from David Hawthorn and data processing assistance from Victoria Lane (SEIS-UK). We acknowledge the help, advice and support of Jarðfeingi, especially Thomas Varming, Uni Petersen, Bartal Højgaard, Romica Øster and Heri Ziska. Rannvá M. Arge and Magni Jøkladal are thanked for their assistance with fieldwork. Research undertaken in this article was supported by the Carnegie Trust for the Universities of Scotland, via a Collaborative Research Grant. Rosie Fletcher is thanked for her comments, which greatly improved the text.Peer reviewedPostprin

Large-scale numerical modeling of hydro-acoustic waves generated by tsunamigenic earthquakes

Abstract. Tsunamigenic fast movements of the seabed generate pressure waves in weakly compressible seawater, namely hydro-acoustic waves, which travel at the sound celerity in water (about 1500 m s−1). These waves travel much faster than the counterpart long free-surface gravity waves and contain significant information on the source. Measurement of hydro-acoustic waves can therefore anticipate the tsunami arrival and significantly improve the capability of tsunami early warning systems. In this paper a novel numerical model for reproduction of hydro-acoustic waves is applied to analyze the generation and propagation in real bathymetry of these pressure perturbations for two historical catastrophic earthquake scenarios in Mediterranean Sea. The model is based on the solution of a depth-integrated equation, and therefore results are computationally efficient in reconstructing the hydro-acoustic waves propagation scenarios

Neuronal nitric oxide synthase (NOS I) in the buffalo epididymis

The localization of neuronal nitric oxide (NOS I) in the buffalo epididymis have been investigated by nicotinamide adenite dinucleotide phosphatase-diaphorase (NADPH-d) histochemichemistry to the light microscope (LM) and NOS immunoistochemistry to the scanning electron microscope (SEM), respectively. Histochemistry: examination of epididymis specimens revealed an intense NADPH-d staining in the basal cell epithelium and endothelium cells of blood vessel. The NADPH diaphorase staining was diffuse and granular only along the caput epididymal epithelium. NADPH diaphorase staining was less intense or absent in the corpus and in the cauda of epididymis. Dense NADPH diaphorase is labeling in the endothelium of blood vessels along the whole buffalo epididymis. Immunoistochemistry: intense NOS I immunoreactivity was detected in the caput epididymis specimen by immuno-SEM. The basal epithelium showed intense and wide-spread immunoreactivity. In the corpus and in the cauda of the epididymis not observed NOS I immunoreactivity. The specific localization of NOS I in buffalo epididymis suggest that nitric oxide may be involved to explain epididymal function: maturation and storage