Large structures and tethers working group

The Large Structures and Tethers Working Group sought to clarify the meaning of large structures and tethers as they related to space systems. Large was assumed to mean that the characteristic length of the structure was greater than one of such relevant plasma characteristics as ion gyroradius or debey length. Typically, anything greater than or equal to the Shuttle dimensions was considered large. It was agreed that most large space systems that the tether could be better categorized as extended length, area, or volume structures. The key environmental interactions were then identified in terms of these three categories. In the following Working Group summary, these categories and the related interactions are defined in detail. The emphasis is on how increases in each of the three spatial dimensions uniquely determine the interactions with the near-Earth space environment. Interactions with the environments around the other planets and the solar wind were assumed to be similar or capable of being extrapolated from the near-Earth results. It should be remembered in the following that the effects on large systems do not just affect specific technologies but will quite likely impact whole missions. Finally, the possible effects of large systems on the plasma environment, although only briefly discussed, were felt to be of potentially great concern

Broadband X-ray properties of black holes GRS 1758-258 and 1E 1740.7-2942: AstroSat and NuSTAR results

We present the results on broadband X-ray properties of persistent black hole binaries GRS 1758$-$258 and 1E 1740.7$-$2942 using AstroSat, NuSTAR and Swift-XRT observations carried out during 2016$-$2022. We perform spectral modeling of both sources after eliminating the contamination in their \textit{LAXPC} spectra from nearby X-ray sources. Preliminary spectral modelling using Comptonization and line emission ($\sim$ 6.4 keV) models suggest that GRS 1758$-$258 occupies both dim-soft state ($kT_{bb}=0.37\pm0.01$ keV, $\Gamma\sim5.9$, $L_{bol}=1$ of Eddington luminosity L$_{Edd}$) and hard state ($\Gamma=1.64-2.22$, $kT_{e}$=4$-$45 keV, $L_{bol}$=1$-$5 % L$_{Edd}$) that requires a multi-colour disc blackbody model ($kT_{in}=0.54\pm0.01$ keV) occasionally. 1E 1740.7$-$2942 instead is found only in hard state ($\Gamma$=1.67$-$2.32, $kT_{e}$=5$-$16 keV, $L_{bol}$=1$-$2 % L$_{Edd}$). Reflection properties of both sources are studied by applying relativistic reflection model RELXILL to the broadband spectra. Our results from \textit{AstroSat} and \textit{NuSTAR} consistently unveiled the presence of a Comptonizing region along with an ionized reflection region (ionization parameter $log\xi$=2.7$-$3.8 and 2.7$-$4.7 erg cm s$^{-1}$ in GRS 1758$-$258 and 1E 1740.7$-$2942 respectively) in both sources. Reflection modeling revealed GRS 1758$-$258 to have a high metal abundance ($A_{fe}=3.9^{+0.4}_{-0.3}$ times solar metal abundance) and inclination angle ($i$) of $61\pm2^{\circ}$. In case of 1E 1740.7$-$2942, $i$ is constrained to be $55\pm1^{\circ}$. Finally, we discuss the implication of our findings in the context of accretion dynamics by comparing our results with the previous studies.Comment: Accepted for publication in MNRA

Further observations of space shuttle plasma‐electrodynamic effects from OSS‐1/STS‐3

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95259/1/grl3101.pd

Determining Gestational Age in a Low-resource Setting: Validity of Last Menstrual Period

The validity of three methods (last menstrual period [LPM], Ballard and Dubowitz scores) for assessment of gestational age for premature infants in a low-resource setting was assessed, using antenatal ultrasound as the gold standard. It was hypothesized that LMP and other methods would perform similarly in determining postnatal gestational age. Concordance analysis was applied to data on 355 neonates of <33 weeks gestational age enrolled in a topical skin-therapy trial in a tertiary-care children's hospital in Bangladesh. The concordance coefficient for LMP, Ballard, and Dubowitz was 0.878, 0.914, and 0.886 respectively. LMP and Ballard underestimated gestational age by one day (±11) and 2.9 days (±7.8) respectively while Dubowitz overestimated gestational age by 3.9 days (±7.1) compared to ultrasound finding. LMP in a low-resource setting was a more reliable measure of gestational age than previously thought for estimation of postnatal gestational age of preterm infants. Ballard and Dubowitz scores are slightly more reliable but require more technical skills to perform. Additional prospective trials are warranted to examine LMP against antenatal ultrasound for primary assessment of neonatal gestational age in other low-resource settings

Dynamics of DNA replication loops reveal temporal control of lagging-strand synthesis

In all organisms, the protein machinery responsible for the replication of DNA, the replisome, is faced with a directionality problem. The antiparallel nature of duplex DNA permits the leading-strand polymerase to advance in a continuous fashion, but forces the lagging-strand polymerase to synthesize in the opposite direction. By extending RNA primers, the lagging-strand polymerase restarts at short intervals and produces Okazaki fragments. At least in prokaryotic systems, this directionality problem is solved by the formation of a loop in the lagging strand of the replication fork to reorient the lagging-strand DNA polymerase so that it advances in parallel with the leading-strand polymerase. The replication loop grows and shrinks during each cycle of Okazaki fragment synthesis. Here we use single-molecule techniques to visualize, in real time, the formation and release of replication loops by individual replisomes of bacteriophage T7 supporting coordinated DNA replication. Analysis of the distributions of loop sizes and lag times between loops reveals that initiation of primer synthesis and the completion of an Okazaki fragment each serve as a trigger for loop release. The presence of two triggers may represent a fail-safe mechanism ensuring the timely reset of the replisome after the synthesis of every Okazaki fragment.

Emergence of structural and dynamical properties of ecological mutualistic networks

Mutualistic networks are formed when the interactions between two classes of species are mutually beneficial. They are important examples of cooperation shaped by evolution. Mutualism between animals and plants plays a key role in the organization of ecological communities. Such networks in ecology have generically evolved a nested architecture independent of species composition and latitude - specialists interact with proper subsets of the nodes with whom generalists interact. Despite sustained efforts to explain observed network structure on the basis of community-level stability or persistence, such correlative studies have reached minimal consensus. Here we demonstrate that nested interaction networks could emerge as a consequence of an optimization principle aimed at maximizing the species abundance in mutualistic communities. Using analytical and numerical approaches, we show that because of the mutualistic interactions, an increase in abundance of a given species results in a corresponding increase in the total number of individuals in the community, as also the nestedness of the interaction matrix. Indeed, the species abundances and the nestedness of the interaction matrix are correlated by an amount that depends on the strength of the mutualistic interactions. Nestedness and the observed spontaneous emergence of generalist and specialist species occur for several dynamical implementations of the variational principle under stationary conditions. Optimized networks, while remaining stable, tend to be less resilient than their counterparts with randomly assigned interactions. In particular, we analytically show that the abundance of the rarest species is directly linked to the resilience of the community. Our work provides a unifying framework for studying the emergent structural and dynamical properties of ecological mutualistic networks.Comment: 10 pages, 4 figure

Dense-core senile plaques in the Flemish variant of Alzheimer's disease are vasocentric

Alzheimer's disease (AD) is characterized by deposition of beta-amyloid (Abeta) in diffuse and senile plaques, and variably in vessels. Mutations in the Abeta-encoding region of the amyloid precursor protein (APP) gene are frequently associated with very severe forms of vascular Abeta deposition, sometimes also accompanied by AD pathology. We earlier described a Flemish APP (A692G) mutation causing a form of early-onset AD with a prominent cerebral amyloid angiopathy and unusually large senile plaque cores. The pathogenic basis of Flemish AD is unknown. By image and mass spectrometric Abeta analyses, we demonstrated that in contrast to other familial AD cases with predominant brain Abeta42, Flemish AD patients predominantly deposit Abeta40. On serial histological section analysis we further showed that the neuritic senile plaques in APP692 brains were centered on vessels. Of a total of 2400 senile plaque cores studied from various brain regions from three patients, 68% enclosed a vessel, whereas the remainder were associated with vascular walls. These observations were confirmed by electron

The quantum structure of black holes

We give an elementary review of black holes in string theory. We discuss black hole entropy from string microstates and Hawking radiation from these states. We then review the structure of 2-charge microstates, and explore how `fractionation' can lead to quantum effects over macroscopic length scales of order the horizon radius.Comment: Review article, 58 pages, 2 figures; references added, note about topics covere