57 research outputs found
The Photocatalytic Activity of TiO 2
In this research different composites of impregnated TiO2 with LTA or FAU zeolites were used as different weight% ratio for photodegradation of organic dye. Normal laboratory UV-lamps were used as a source of UV irradiation. In addition a setup of system of mirrors was used to collect real Jeddah sunlight. A comparison of UV and real sunlight photodegradation activity showed that the real sunlight enhances new centers of active sites exhibiting higher catalytic activity than that of UV irradiated samples
Impact of Block Length and Temperature over Self-Assembling Behavior of Block Copolymers
Self-assembling behavior of block copolymers having water-soluble portion as one of the blocks plays key role in the properties and applications of the copolymers. Therefore, we have synthesized block copolymers of different block length and investigated their self-assembling behavior with reference to concentration and temperature using surface tension and conductance measurement techniques. The results obtained through both techniques concluded that critical micelles concentration (CMC) was decreased from 0.100 to 0.078âg/dL with the increase in length of water insoluble block and 0.100 to 0.068âg/dL for the increased temperature. ÎGmic was also decreased with the increase in temperature of the system, concluding that the micellization process was encouraged with the increase in temperature and block length. However, ÎHmic values were highest for short block length copolymer. The surface excess concentration obtained from surface tension data concluded that it was highest for short block length and vice versa and was increased with the increase in temperature of the system. However, the minimum area per molecule was largest for highest molecular weight copolymers or having longest water insoluble block and decreases with the increase in temperature
Peripheral Blood Stem Cells versus Bone Marrow for T Cell-Replete Haploidentical Transplantation with Post-Transplant Cyclophosphamide in Hodgkin Lymphoma.
Abstract Haploidentical stem cell transplantation (haplo-SCT) with post-transplant cyclophosphamide (PT-Cy) represents a potential curative strategy for patients with Hodgkin lymphoma (HL) when a matched related or unrelated donor is not available. The role of graft source, either bone marrow (BM) or peripheral blood stem cells (PBSCs), in this setting has not been fully elucidated. We performed a retrospective study on 91 patients with HL to compare the outcome after BM (nâŻ=âŻ53) or PBSC (nâŻ=âŻ38) transplant. Eighty-nine patients engrafted with no difference between BM and PBSCs in terms of median time for neutrophil (20 versus 20 days, PâŻ=âŻ.405) and platelet (26 versus 26.5 days, PâŻ=âŻ.994) engraftment. With a median follow-up of 40.2 months, 100-day cumulative incidences of grades II to IV acute graft-versus host disease (GVHD) and grades II to IV acute GVHD were 24% and 4%, respectively. Graft source was not associated with a different risk of acute GVHD both by univariate and multivariate analyses. Consistently, 1-year cumulative incidence of chronic GVHD was 7% with no differences between the 2 graft types (PâŻ=âŻ.761). Two-year rates of overall survival (OS), progression-free survival (PFS), nonrelapse mortality, and GVHD/relapse-free survival (GRFS) were 67%, 58%, 20%, and 52%, respectively. By univariate analysis, pretransplant disease status was the main variable affecting all outcomes. By multivariate analysis, PBSCs resulted in a protective factor for OS (hazard ratio [HR], .29; PâŻ=âŻ.006), PFS (HR, .38; PâŻ=âŻ.001), and GRFS (HR, .44; PâŻ=âŻ.020). The other independent variables affecting the final outcome were pretransplant disease status and hematopoietic cell transplantâspecific comorbidity index. In conclusion, when planning a haplo-SCT with PT-Cy for patients with poor-risk HL, graft type is an important variable to take into account when selecting the best available donor
Antithymocyte Globulin in Reduced-Intensity Conditioning Regimen Allows a High Disease-Free Survival Exempt of Long-Term Chronic Graft-versus-Host Disease
AbstractNonmyeloablative (NMA) regimens allow the use of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients considered unfit for standard myeloablative conditioning (MAC) regimens using high-dose alkylating agents with or without total body irradiation (TBI). Reduced-intensity conditioning (RIC) regimens, based on fludarabine (Flu), busulfan (Bu), and rabbit antithymocyte globulin (r-ATG), represent an intermediate alternative between NMA and MAC regimens. This platform was subsequently optimized by the introduction of i.v. Bu and the use of 5Â mg/kg r-ATG, based on the hypothesis that these modifications would improve the safety of RIC allo-HSCT. Here we report a study conducted at our institution on 206 patients, median age 59Â years, who underwent allo-HSCT after conditioning with Flu, 2Â days of i.v. Bu, and 5Â mg/kg r-ATG (FBx-ATG) between 2005 and 2012. The prevalence of grade III-IV acute graft-versus-host disease (GVHD) was 9%, and that of extensive chronic GVHD was 22%. Four-year nonrelapse mortality (NRM), relapse, and overall survival (OS) rates were 22%, 36%, and 54%, respectively. NRM tended to be influenced by comorbidities (hematopoietic cell transplantationâspecific comorbidity index [HCT-CI] <3 versus HCT-CI â„3: 18% versus 27%; PÂ =Â .075), but not by age (<60Â years, 20% versus â„60Â years, 25%; PÂ =Â .142). Disease risk significantly influenced relapse (2Â years: low, 8%, intermediate, 28%, high, 34%; very high, 63%; PÂ =Â .017). Both disease risk (hazard ratio [95% confidence interval]: intermediate, 2.1 [0.8 to 5.2], PÂ =Â .127; high, 3.4 [1.3 to 9.1], PÂ =Â .013; very high, 4.0 [1.1 to 14], PÂ =Â .029) and HCT-CI (hazard ratio [95% confidence interval]: HCT-CI â„3, 1.7 (1.1 to 2.8), PÂ =Â .018) influenced OS, but age and donor type did not. The FBx-ATG RIC regimen reported here is associated with low mortality and high long-term disease-free survival without persistent GVHD in both young and old patients. It represents a valuable platform for developing further post-transplantation strategies aimed at reducing the incidence of relapse, particularly in the setting of high-risk disease
Evaluation de la maladie du greffon contre l'hÎte aprÚs greffe de sang placentaire conditionnée par un régime à intensité réduite chez l'adulte
AIX-MARSEILLE2-BU MĂ©d/Odontol. (130552103) / SudocSudocFranceF
New Surface Aspects towards Photocatalytic Activity of Doped Supported Titanium Dioxide
The present work aims to synthesize nanoscale well dispersed TiO2/SiO2 and TiO2/Al2O3 nanoparticle photocatalysts via an impregnation method for the removal of methyl orange, which was used as a model compound of organic pollutant in wastewater, from an aqueous medium. Also within this frame work, La and Ce metals were loaded onto the surfaces of TiO2/SiO2 and TiO2/Al2O3 by an impregnation method to enhance the photocatalytic activity of the nanoparticles; the activities and physicochemical properties of the photocatalysts were compared before and after loading of metallic La and Ce. The oxide system was characterized by different techniques, including XRD, UV-Vis spectroscopy, FT-IR spectroscopy, SEM, and EDX spectroscopy. Finally, the optimal conditions to complete the photocatalytic oxidation of methyl orange dye were studied. This work holds promise for the efficient photodegradation of pollutants by nanoparticle photocatalysts
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