Management of Odontogenic and Nonodontogenic Oral Pain

Pain in the orofacial region is by far the commonest reason for patients to seek treatment. Tooth and intraoral structures are often the main sources of orofacial pain. Odontogenic pain, also commonly known as tooth pain, originates from dental structures, pulpal or periodontal. Nonodontogenic oral pain can originate from intraoral structures such as gingiva and buccal mucosa. Arriving at a correct and definitive diagnosis is of paramount importance to institute an appropriate treatment. Obtaining a detailed history from the patient including the location, duration, frequency, periodicity, character, and quality of pain assists in differentiating odontogenic from nonodontogenic causes. Wide varieties of pharmacological agents, along with invasive and noninvasive procedures, are available to manage odontogenic and nonodontogenic pain. While managing orofacial pain, clinical and pharmacological judgment should encompass a systematic and objective assessment in compliance with the strongest evidence available. In this chapter, there will be a discussion of various choices and options available to manage a few of the orofacial pain complaints

'R&D vital in high income nation goal' crucial: Higher learning institutions can create an innovation-driven economy, says Kamalanathan

RESEARCH and development(R&D)is the key ingredient that could drive Malaysia towards its goal of achieving a high-income nation status by 2020. Deputy Education Minister II P. Kamalanathan said R&D was crucial to enable Malaysia to move from an efficiency-driven economy to an innovation-driven one."R&D will propel Malaysia to become a high-income country based on knowledge,innovation and creativity by 2020.

Hudud call a Pas ploy: POWER PLAY: Kelantan govt's announcement to appease some quarters, says don

PAS' decision to implement hudud in Kelantan is a gim­mick to appease some quarters, said a political analyst. Universiti Utara Malaysia's School of International Studies dean Associate Professor Dr Mohd Azizuddin Mohd Sani said the move was just to please some quar­ters in Kelantan

Qualitative Analysis of Root Canal Treatments performed by Undergraduate Students: A Retrospective Study

Objective: To analyze the technical quality of endodontic treatment carried out at the undergraduate dental clinics. Material and Methods: Random radiographic records of 92 patients’ were selected who received endodontic treatment by the undergraduate students from June 2018 to July 2019. The quality of root canal filling was determined in relation to the adequate density, length, and taper. Statistical analysis was performed by using GraphPad (Prism 5), and to determine the association between different variables Chi-square test was used. Results: Adequate technical quality of canal obturation conducted by the undergraduate students was found in less than 65% of the cases. The frequency of adequate root canal taper was significantly greater in maxillary teeth (75%) as compared to mandibular teeth (33%); however, adequacy of acceptable density was found more in maxillary teeth (62%) as compared to mandibular teeth (55%). A statistically significant difference was seen in the quality of root canal fillings between anterior and posterior teeth (p=0.001). Conclusion: The root canal therapy performed by undergraduate students was less than optimum in terms of technical quality. Hence, it is suggested that the endodontic training courses delivered at pre-clinical and clinical levels for undergraduate students must be thoroughly revised

DEVELOPMENT OF NEW PYRAZOLE HYBRIDS AS ANTITUBERCULAR AGENTS: SYNTHESIS, BIOLOGICAL EVALUATION AND MOLECULAR DOCKING STUDY

Objective: synthesis of new 1, 3-diphenyl pyrazole derivatives 9(a-f) and 10(a-f) using molecular hybridization approach for antitubercular and cytotoxic studies.Methods: The structures of synthesized compounds were confirmed by 1H-NMR, 13C-NMR and mass spectra's. The antitubercular activity of compounds and standard drugs were assessed against Mycobacterium tuberculosis using microplate Alamar Blue assay (MABA).  The cytotoxic activities were performed by Sulforhodamine B (SRB) assay. The molecular docking and in silico ADME prediction were studied by using Schrodinger.Results: The results reveals that the compounds 9c, 9d, 10c and 10d exhibited substantial antitubercular potential with MIC < 20 μM. The cytotoxic studies revealed that the active compounds (9d, 10a, and 10d) are non-toxic to HeLa cancer cell lines with selectivity index >10. The molecular docking study was performed to study the binding orientation and affinity of synthesized compounds for InhA enzyme.Conclusion: The study explored that the 1, 3-diphenyl pyrazole hybrids coupled with well known antitubercular drugs could be a potential lead for antitubercular agents. In-silico molecular docking study helps to identify their corresponding intermolecular ligand-protein interactions with target enzyme. Also ADME prediction studies revealed that the compounds were in acceptable range to have pharmacokinetic parameters

Review on Nanorobot as a Nanomachine and Biomedicine

Nanorobotics is the technology of producing robots or machines with very small scale or Miniscale of a nanometer (10-9 meters), machines constructed at the molecular level (Nano machines) may Be used to detect or identify and cure the human body of its various diseases like cancer. Nano robots are Very good accuracy they perform a specific task with great accuracy and precision at very small scale or Nanoscale dimension. A recent discovery in the field of drug Delivery is target therapy, which improves the diagnostic tests and Medical devices. Nanotechnology is going to revolutionize the world. According to the National Nanotechnology Initiative (NNI). Nowadays these nano robots play a vital role in the field of Bio Medicine. In the pharma-world, the applications of Nanotechnology mean drugs containing nano-sized active ingredients. They are well used to cure HIV, Cancer, Surgery, Bloodstream, gene therapy, Kidney stone removal and other harmful disease they Can restore lost tissue at the cellular level, useful for monitoring, Diagnosing and fighting sickness. The main purpose is to cure many dreadful Diseases in human body

Review on Therapeutic Uses of Mimosa Pudica (Touch-me-not) Plant

The prostrate or semi-erect subshrub Mimosa pudica L. (Mimosacee), referred to as touch me not, live and die, shame plant, and humble plant, is indigenous to North and South America as well as Australia. They are delicate soft grey green leaves that fold and droop at night or when handled and chilled, and they are thickly equipped with recurved thorns in India. Its peculiar bending behaviors have given it the nickname "curiosity plant." According to Ayurveda, the root of this plant is bitter, acrid, cooling, vulnerary, and alexipharmic. Leprosy, dysentery, vaginal and uterine complaints, inflammations, burning sensations, asthma, leucoderma, tiredness, and blood disorders are among the conditions it is used to treat. It appears to be a prospective herbal candidate deserving of further research, as shown by its pharmacological profile Numerous illnesses, including cancer, diabetes, hepatitis, obesity, and urinary infections, are also prevented or treated using mimosa pudica. It predominantly contains pharmacological activities that include antibacterial, antivenom, antitertility, anticonvulsant, depressant, aphrodisiac, and others. The plant has been used to treat urogenital issues for ages

PLC & SCADA based substation automation

lectrical power systems are a technical wonder. Electricity and its accessibility are the\ud greatest engineering achievements of the 20th century. A modern society cannot exist without electricity.\ud Generating stations, transmission lines and distribution systems are the main components of\ud power system. Smaller power systems (called regional grids) are interconnected to form a larger network\ud called national grid, in which power is exchanged between different areas depending upon surplus and\ud deficiency. This requires a knowledge of load flows, which is impossible without meticulous planning and\ud monitoring .Also, the system needs to operate in such a way that the losses and in turn the cost of\ud production are minimum.\ud The major factors that influence the operation of a power system are the changes in load and\ud stability. As is easily understood from the different load curves and load duration curve, the connected\ud load, load varies widely throughout the day. These changes have an impact on the stability of power\ud system. As a severe change in a short span can even lead to loss of synchronism. Stability is also affected\ud by the occurrence of faults, Faults need to be intercepted at an easily stage and corrective measures like\ud isolating the faulty line must be taken.\ud As the power consumption increases globally, unprecedented challenges are being faced,\ud which require modern, sophisticated methods to counter them. This calls for the use of automation in the\ud power system. The Supervisory Control and Data Acquisition (SCADA) and Programmable Logic\ud Controllers (PLC) are an answer to this.\ud SCADA refers to a system that enables on electricity utility to remotely monitor, co-ordinate,\ud control and operate transmission and distribution components, equipment and real-time mode from a\ud remote location with acquisition at date for analysis and planning from one control location.\ud PLC on the other hand is like the brain of the system with the joint operation of the SCADA\ud and the PLC, it is possible to control and operate the power system remotely. Task like\ud Opening of circuit breakers, changing transformer taps and managing the load demand can be carried out\ud efficiently.\ud This type of an automatic network can manage load, maintain quality, detect theft of\ud electricity and tempering of meters. It gives the operator an overall view of the entire network. Also, flow\ud of power can be closely scrutinized and Pilferage points can be located. Human errors leading to tripping\ud can be eliminated. This directly increases the reliability and lowers the operating cost.\ud In short our project is an integration of network monitoring functions with geographical\ud mapping, fault location, load management and intelligent metering