Automated breast profile segmentation for ROI detection using digital mammograms

Abstract—Mammography is currently the most effective imaging modality used by radiologists for the screening of breast cancer. Finding an accurate, robust and efficient breast profile segmentation technique still remains a challenging problem in digital mammography. Extraction of the breast profile region and the pectoral muscle is an essential pre-processing step in the process of computer-aided detection. Primarily it allows the search for abnormalities to be limited to the region of the breast tissue without undue influence from the background of the mammogram. The presence of pectoral muscle in mammograms biases detection procedures, which recommends removing the pectoral muscle during mammogram pre-processing. In this paper we explore an automated technique for mammogram segmentation. The proposed algorithm uses morphological preprocessing and seeded region growing (SRG) algorithm in order to: (1) remove digitization noises, (2) suppress radiopaque artifacts, (3) separate background region from the breast profile region, and (4) remove the pectoral muscle, for accentuating the breast profile region. To demonstrate the capability of our proposed approach, digital mammograms from two separate sources are tested using Ground Truth (GT) images for evaluation of performance characteristics. Experimental results obtained indicate that the breast regions extracted accurately correspond to the respective GT images

Computer-aided acute leukemia blast cells segmentation in peripheral blood images

Computer-aided diagnosis system of leukemic cells is vital tool, which can assist domain experts in the diagnosis and evaluation procedure. Accurate blast cells segmentation is the initial stage in building a successful computer-aided diagnosis system. Blast cells segmentation is still an open research topic due to several problems such as variation of blats cells in terms of color, shape and texture, touching and overlapping of cells, inconsistent image quality, etc. Although numerous blast cells segmentation methods have been developed, only few studies attempted to address these problems simultaneously. This paper presents a new image segmentation method to extract acute leukemia blast cells in peripheral blood. The first aim is to segment the leukemic cells by mean of color transformation and mathematical morphology. The method also introduces an approach to split overlapping cells using the marker-controlled watershed algorithm based on a new marker selection scheme. Furthermore, the paper presents a powerful approach to separate the nucleus region and the cytoplasm region based on the seeded region growing algorithm powered by histogram equalization and arithmetic addition to handle the issue of non-homogenous nuclear chromatin pattern. The robustness of the proposed method is tested on two datasets comprise of 1024 peripheral blood images acquired from two different medical centers. The quantitative evaluation reveals that the proposed method obtain a better segmentation performance compared with its counterparts and achieves remarkable segmentation results of approximately 96 % in blast cell extraction and 94 % in nucleus/cytoplasm separation

Institutional repositories: Review and knowledge management perspective

This paper provides a review on current literatures on the concept Institutional Repository (IR) and to propose the use of KM theory to provide understanding on the implementation of IR. We will discuss the issues relevant to IR from the KM view by providing examples which indicated that research can be build on the knowledge gained by KM researchers to augment the understanding of IR. This paper will contribute in bringing together recent research in IR and KM and how these two concepts can collaborate in resulting better understanding of IR implementation

An application of belief merging for the diagnosis of oral cancer

Machine learning employs a variety of statistical, probabilistic, fuzzy and optimization techniques that allow computers to “learn” from examples and to detect hard-to-discern patterns from large, noisy or complex datasets. This capability is well-suited to medical applications, and machine learning techniques have been frequently used in cancer diagnosis and prognosis. In general, machine learning techniques usually work in two phases: training and testing. Some parameters, with regards to the underlying machine learning technique, must be tuned in the training phase in order to best “learn” from the dataset. On the other hand, belief merging operators integrate inconsistent information, which may come from different sources, into a unique consistent belief set (base). Implementations of merging operators do not require tuning any parameters apart from the number of sources and the number of topics to be merged. This research introduces a new manner to “learn” from past examples using a non parametrised technique: belief merging. The proposed method has been used for oral cancer diagnosis using a real-world medical dataset. The results allow us to affirm the possibility of training (merging) a dataset without having to tune the parameters. The best results give an accuracy of greater than 75%

An ensemble CRT, RVFLN, SVM method for estimating Propane Spot Price

In this paper, we propose an ensemble of the CRT-RVFLN-SVM (Classification and Regression Tree (CRT), Random Variable Functional Link Neural Network (RVFLN), and Support Vector Machine (SVM)) to improve robustness and effectiveness in estimating propane spot price. The propane spot price data which are collected from the Energy Information Administration of the US Department of Energy and Barchart were used to build an ensemble CRT-RVFLN-SVM model for the estimating of propane spot price. For the purpose of evaluation, the constituted intelligent computing technologies of the proposed ensemble methodology in addition to Multilayer Back-Propagation Neural Network (MBPNN) were also applied to estimate the propane spot price. Experimental results show that the proposed ensemble CRT-RVFLN-SVM model has improved the performance of CRT, RVFLN, SVM, and MBPNN. The can help to reduce the level of future uncertainty of the propane spot price. Propane investors can use our model as an alternative investment tool for generating more revenue because accurate estimations of future propane price implies generating more profit

Neural networks optimization through genetic algorithm searches: A review

Neural networks and genetic algorithms are the two sophisticated machine learning techniques presently attracting attention from scientists, engineers, and statisticians, among others. They have gained popularity in recent years. This paper presents a state of the art review of the research conducted on the optimization of neural networks through genetic algorithm searches. Optimization is aimed toward deviating from the limitations attributed to neural networks in order to solve complex and challenging problems. We provide an analysis and synthesis of the research published in this area according to the application domain, neural network design issues using genetic algorithms, types of neural networks and optimal values of genetic algorithm operators (population size, crossover rate and mutation rate). This study may provide a proper guide for novice as well as expert researchers in the design of evolutionary neural networks helping them choose suitable values of genetic algorithm operators for applications in a specific problem domain. Further research direction, which has not received much attention from scholars, is unveiled

Automated Bone Age Assessment: Motivation, Taxonomies, and Challenges

Bone age assessment (BAA) of unknown people is one of the most important topics in clinical procedure for evaluation of biological maturity of children. BAA is performed usually by comparing an X-ray of left hand wrist with an atlas of known sample bones. Recently, BAA has gained remarkable ground from academia and medicine. Manual methods of BAA are time-consuming and prone to observer variability. This is a motivation for developing automated methods of BAA. However, there is considerable research on the automated assessment, much of which are still in the experimental stage. This survey provides taxonomy of automated BAA approaches and discusses the challenges. Finally, we present suggestions for future research