Study of maternal and perinatal outcome in women with congenital heart disease

Background: Pregnancy induced changes in cardiovascular hemodynamics are generally well tolerated. However, the reversible but prolonged hemodynamic stress of pregnancy can have negative effects on the diseased heart. In our study we studied various uncorrected and corrected congenital cardiac lesions and their antenatal, intrapartum course, their ability to withstand labor and postpartum complications. Methods: Our study was a retroprospective observational cross-sectional study conducted at KEM hospital, Mumbai with enrolment of total 27 subjects over a period of 18 months between August 2020 to December 2021.The study included all the registered and emergency patients either post abortal or post-delivery with congenital cardiac diseases including the ones who were surgically corrected. Results: The present study was conducted to study demographic features and maternal and perinatal outcomes of pregnancy in these women. Majority of the subjects were diagnosed with heart disease at the age more than 20 years (40.74%) and very few at age less than 5 years. In the present study only 7.4% study subjects were aware about pre-marital counselling, and preconceptional counselling. Among the lesions ASD was commonest reported among 51.85% study subjects. ICU admission was required among 11.11% study subjects. Labour analgesia given to only 18.52% study subjects. We did not observe any association between surgically corrected CHD and ICU admissions, postnatal complications, and outcomes, p>0.05. Conclusions: This study concluded that pre-pregnancy diagnosis, counselling, appropriate referral, routine antenatal supervision and delivery at an equipped centre improve the overall outcomes

Biochemical assessment of renal function and its correlation with iron overloading in different variants of thalassemia

Thalassemia is a hereditary disorder characterised by changes in organ function and iron overload resulting from multiple blood transfusions, inefficient erythropoiesis, and increased gastrointestinal iron absorption. This study aimed to compare and correlate renal function tests with blood transfusion frequency, annual blood requirement, and ferritin levels in patients with Thalassemia Major, Intermedia, and Minor. Fifty blood samples were collected from each clinically diagnosed patient with thalassemia major, intermedia, and minor at MGM Hospital in Navi Mumbai for complete blood count estimates, serum ferritin, and renal function tests. The frequency of blood transfusions and the annual blood requirement was recorded. The Pearson correlation coefficient was used to examine the relationship. SPSS Software was used to tabulate and process patient data. A p-value of less than 0.001 was regarded as significant. This study included both male (64) and female (84) participants. The major, intermedia, and minor serum ferritin levels were 2212.5 ug/L, 1643 ug/L, and 53.55 ug/L, respectively. Serum creatinine and sodium levels in thalassemia major (27.41 ± 5.31umol/L, 128.02± 4.56 mmol/L, respectively)  and intermedia (36.25 ± 6.19 umol/L, 128.96± 4.39 mmol/L respectively) decreased as the frequency of transfusion and serum ferritin level increased. Uric acid levels (361.64 ± 64.83 umol/L) were higher in patients with thalassemia intermedia. Transfusion therapy, required for Major and Intermedia, increases iron overload, which harms organ function and quality of life. Early detection and genetic counselling are necessary for proper thalassemia management.

PREBIOTIC POTENTIAL OF STARCH OF TINOSPORA CORDIFOLIA, A COMPONENT OF SOMAVIT®: AN IN VITRO STUDY ON GROWTH MODULATION OF BIFIDOBACTERIUM AND LACTOBACILLUS STRAINS

Prebiotic is a substrate that is selectively utilized by host microorganisms conferring a health benefit. The present study aimed to investigate the prebiotic potential of starch of Tinospora cordifolia (5% w/v) based on in vitro growth stimulation of Lactobacillus plantarum and Bifidobacterium bifidum, using individual strains and consortia. Bacterial cultures were incubated under anaerobic conditions with starch of Tinospora cordifolia (test) and with distilled water as the control. At various contact time points (0, 1, 48 and 96 hours), small aliquots were sampled. The organisms were plated on specific growth media under anaerobic conditions for Bifidobacterium and microaerophilic for Lactobacillus, and total viable count was determined by standard plate count. Starch of Tinospora cordifolia promoted growth of both bacterial strains, singly and in consortia. The mean log colony forming units (CFU) ± standard deviation of Lactobacillus in test was significantly higher in comparison to control (8.09±0.07 vs 7.06±0.03, p<0.05) at 48 hours incubation, thereafter the growth of Lactobacillus plateaued through 96 hours. CFUs for Bifidobacterium in test were 8.52±0.28 at 48 hours and 8.74±0.14 at 96 hours incubation, both significantly higher (p<0.005) when compared to control. Bifidobacterium in test exhibited 90-fold relative increase in growth when compared to control. Lactobacillus being more robust showed an immediate increase in growth, while Bifidobacterium demonstrated a delayed but sustained growth, which extended over a period of time. These findings suggest that Starch of Tinospora cordifolia may enhance the gastrointestinal health of the host through modulation of overall composition of gut microbiota

Evaluation of influence of incisal guidance on the force exerted at the maximum possible intercuspal position and in protrusion – An In vivo study

Aim: Incisal guidance (IG) varies with maxillary and mandibular teeth wear. It in turn governs the forces on adhesive restorations. The present study evaluates the variation in forces because of changes in IG. Materials and Methods: IG was recorded on 46 subjects along with the distance from centric contact to incisal edge. Biteforce was recorded in the maximum possible intercuspal position (MIP) and in protrusion in the anterior region. Data analysis was performed using SPSS Version 21 at a confidence level ≤0.05. Pearson correlation test was applied to determine r value. Results: The association between forces on anterior teeth in MIP and forces on teeth in contact in protrusion is statistically significant (P value 0.001). There is definitive correlation between forces exerted in MIP and the distance travelled from centric contact to incisal edge (r = 0.059). There is a weak correlation between forces on anterior teeth in MIP and protrusive IG (r value 0.172). Conclusion: The force on anterior teeth in MIP with steeper IG is higher. Hence, the restoration margin should be kept away from the centric contact point

Abstracts of Scientifica 2022

This book contains the abstracts of the papers presented at Scientifica 2022, Organized by the Sancheti Institute College of Physiotherapy, Pune, Maharashtra, India, held on 12–13 March 2022. This conference helps bring researchers together across the globe on one platform to help benefit the young researchers. There were six invited talks from different fields of Physiotherapy and seven panel discussions including over thirty speakers across the globe which made the conference interesting due to the diversity of topics covered during the conference. Conference Title:  Scientifica 2022Conference Date: 12–13 March 2022Conference Location: Sancheti Institute College of PhysiotherapyConference Organizer: Sancheti Institute College of Physiotherapy, Pune, Maharashtra, Indi