The Effect of Computer Use on Job Quality: Evidence from Europe

This paper studies changes in computer use and job quality in the EU-15 between 1995 and 2015. We document that while the proportion of workers using computers has increased from 40% to more than 60% over twenty years, there remain significant differences between countries even within the same occupations. Several countries have seen a significant increase in computer use even in low-skilled occupations generally assumed to be less affected by technology. Overall, the great increase in computer use between 1995 and 2015 has coincided with a period of modest deterioration of job quality in the EU-15 as whole, as discretion declined for most occupational and educational groups while intensity increased slightly for most of them. Our OLS results that exploit variation within country-occupation cells point to a sizeable positive effect of computer use on discretion, but to small or no effect on intensity at work. Our instrumental variable estimates point to an even more benign effect of computer use on job quality. Hence, the results suggest that the (moderate) deterioration in the quality of work observed in the EU-15 between 1995 and 2015 has occurred despite the spread of computers, rather than because of them

One-loop effective potential in M4 x T2 with and without 't Hooft flux

We review the basic notions of compactification in the presence of a background flux. In extra-dimentional models with more than five dimensions, Scherk and Schwarz boundary conditions have to satisfy 't Hooft consistency conditions. Different vacuum configurations can be obtained, depending whether trivial or non-trivial 't Hooft flux is considered. The presence of the "magnetic" background flux provide, in addition, a mechanism for producing four-dimensional chiral fermions. Particularizing to the six-dimensional case, we calculate the one-loop effective potential for a U(N) gauge theory on M4 x T2. We firstly review the well known results of the trivial 't Hooft flux case, where one-loop contributions produce the usual Hosotani dynamical symmetry breaking. Finally we applied our result for describing, for the first time, the one-loop contributions in the non-trivial 't Hooft flux case

P2O5-free cerium containing glasses: Bioactivity and cytocompatibility evaluation

(1) Background: valuation of the bioactivity and cytocompatibility of P2O5-free and CeO2 doped glasses. (2) Methods: all glasses are based on the Kokubo (K) composition and prepared by a melting method. Doped glassed, K1.2, K3.6 and K5.3 contain 1.2, 3.6, and 5.3 mol% of CeO2. Bioactivity and cytotoxicity tests were carried out in simulated body fluid (SBF) solution and murine osteocyte (MLO-Y4) cell lines, respectively. Leaching of ions concentration in SBF was determined by inductively coupled plasma mass spectrometry (ICP-MS) and optical emission spectrometry (ICP-OES). The surface of the glasses were characterized by scanning electron microscopy (SEM) and X-ray diffraction (XRD) techniques. (3) Results: P2O5-free cerium doped glasses are proactive according to European directives. Cerium increases durability and retards, but does not inhibit, (Ca10(PO4)6(OH)2, HA) formation at higher cerium amounts (K3.6 and K5.3); however, cell proliferation increases with the amount of cerium especially evident for K5.3. (4) Conclusions: These results enforce the use of P2O5-free cerium doped bioactive glasses as a new class of biomaterials

Interleukin-34 promotes tumorigenic signals for colon cancer cells

Colorectal carcinoma (CRC) is one of the most common forms of malignancy in the Western world. Accumulating evidence indicates that colon carcinogenesis is tightly controlled by tumour-associated immune cells and stromal cells, which can either stimulate or suppress CRC cell growth and survival, mainly via the production of cytokines. Interleukin-34 (IL-34), a cytokine known to regulate mainly monocyte/macrophage survival and function, is highly produced within the CRC microenvironment by several cell types, including cancer cells, tumour-associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs), and regulates the pro-tumoural functions of such cells. In this article, we summarize the available data supporting the multiple effects of IL-34 in human CRC

Grain size reduction strategies on Eurofer

One of the options currently taken into account for the realization of the first DEMO reactor is the "water-cooled blanket". This option implies a minimum irradiation temperature for the blanket material in the range of 280–350 °C. In addition to the DBTT (Ductile to Brittle Transition Temperature) shift due to the DPA (displacement per atom) damage under irradiation, also the issue of the increased embrittlement due to He production must be taken into account. This issue appears even more detrimental and less manageable because the DBBT shift due to the Helium production does not saturate with the dose, as it results from previous works reported in literature. The experimental results and the difference in behaviour between ODS (Oxide Dispersion Strengthened Steels) RAFM (Reduced Activation Ferritic Martensitic) and other FM (Ferritic Martensitic) alloys (EM10, P91) showed that it is possible to improve the resistance to He embrittlement by both intra-granular precipitation of Y-Ti oxides and by decreasing the grain size at the same time. Nevertheless, anyway, the multiplication of the grain boundaries increases the dilution of He on grain surface, delaying the formation of He bubbles on grain boundaries and, therefore, the susceptibility to the He embrittlement. Several grain size reduction strategies have then been investigated on EUROFER both at the austenitization stage, on the PAGS (Prior Austenite Grain Size), and at the tempering stage, on the tempered martensite. The microstructural observations have been carried out by means of SEM (Scanning Electron Microscopy). Also the effect of grain size reduction on the toughness of the material will be taken into account; The DBTTs resulting from impact tests on KLST specimens will be shown. The outcomes of the microstructural observations, as well as the preliminary mechanical characterization (impact tests) will be discussed in this paper. Keywords: EUROFER 97, RAFM steels, Microstructure, Multiple normalization, Asymmetric rolling, Recrystallization, KLS