2,719 research outputs found
The DE magnetometer preprocessor users guide
A users guide for the Dynamics Explorer magnetometer preprocessor computer program is provided. This program is written in Xerox Extended FORTRAN IV and is used to process telemetry data in order to provide data files for use in analysis programs. This preprocessor is designed to operate on the Sigma 9 and the IBM 4341
Efficient calibration for high-dimensional computer model output using basis methods
Calibration of expensive computer models with high-dimensional output fields
can be approached via history matching. If the entire output field is matched,
with patterns or correlations between locations or time points represented,
calculating the distance metric between observational data and model output for
a single input setting requires a time intensive inversion of a
high-dimensional matrix. By using a low-dimensional basis representation rather
than emulating each output individually, we define a metric in the reduced
space that allows the implausibility for the field to be calculated
efficiently, with only small matrix inversions required, using projection that
is consistent with the variance specifications in the implausibility. We show
that projection using the norm can result in different conclusions, with
the ordering of points not maintained on the basis, with implications for both
history matching and probabilistic methods. We demonstrate the scalability of
our method through history matching of the Canadian atmosphere model, CanAM4,
comparing basis methods to emulation of each output individually, showing that
the basis approach can be more accurate, whilst also being more efficient
The Relationship Between the Number of Shots and the Quality of Gamma Knife Radiosurgeries
Radiosurgery is a non-invasive alternative to brain surgery that uses a single focused application of high radiation to destroy intracerebral target tissues. A Gamma Knife delivers such treatments by using 201 cylindrically collimated cobalt-60 sources that are arranged in a hemispherical pattern and aimed to a common focal point. The accumulation of radiation at the focal point, called a \shot due to the spherical nature of the dose distribution, is used to ablate (or destroy) target tissue in the brain. If the target is small and spherical, it is easily treated by choosing one of four available collimators (4, 8, 14, or 18 mm). For large, irregular targets, multiple shots are typically required to treat the entire lesion, and the process of determining the optimal arrangement and number of shots is complex. In this research, fast simulated annealing and a novel objective function are used to investigate the relationship between the number of shots and the quality of the resulting treatment. Sets of 5, 10, 25, 50, and an unrestricted number of shots are studied for an arteriovenous malformation (AVM). As the shot limit increases the following improvements in plan quality are observed: the conformity of the prescription isodose line increases, the lesion dose becomes more homogeneous, and an increase use of smaller collimators to deposit dose. Large improvements in plan quality are realized by increasing the number of shots from 5 to 50, and to achieve a similar magnitude of improvement past 50 requires an increase over 1500 shots for the complex lesion investigated. This observation suggests that it is clinically valuable to improve the Gamma Knife\u27s delivery capabilities so that 50 shot treatments are possible
Detection of noise-corrupted sinusoidal signals with Josephson junctions
We investigate the possibility of exploiting the speed and low noise features
of Josephson junctions for detecting sinusoidal signals masked by Gaussian
noise. We show that the escape time from the static locked state of a Josephson
junction is very sensitive to a small periodic signal embedded in the noise,
and therefore the analysis of the escape times can be employed to reveal the
presence of the sinusoidal component. We propose and characterize two detection
strategies: in the first the initial phase is supposedly unknown (incoherent
strategy), while in the second the signal phase remains unknown but is fixed
(coherent strategy). Our proposals are both suboptimal, with the linear filter
being the optimal detection strategy, but they present some remarkable
features, such as resonant activation, that make detection through Josephson
junctions appealing in some special cases.Comment: 22 pages, 13 figure
Quantifying spatio-temporal boundary condition uncertainty for the North American deglaciation
Ice sheet models are used to study the deglaciation of North America at the
end of the last ice age (past 21,000 years), so that we might understand
whether and how existing ice sheets may reduce or disappear under climate
change. Though ice sheet models have a few parameters controlling physical
behaviour of the ice mass, they also require boundary conditions for climate
(spatio-temporal fields of temperature and precipitation, typically on regular
grids and at monthly intervals). The behaviour of the ice sheet is highly
sensitive to these fields, and there is relatively little data from geological
records to constrain them as the land was covered with ice. We develop a
methodology for generating a range of plausible boundary conditions, using a
low-dimensional basis representation of the spatio-temporal input. We derive
this basis by combining key patterns, extracted from a small ensemble of
climate model simulations of the deglaciation, with sparse spatio-temporal
observations. By jointly varying the ice sheet parameters and basis vector
coefficients, we run ensembles of the Glimmer ice sheet model that
simultaneously explore both climate and ice sheet model uncertainties. We use
these to calibrate the ice sheet physics and boundary conditions for Glimmer,
by ruling out regions of the joint coefficient and parameter space via history
matching. We use binary ice/no ice observations from reconstructions of past
ice sheet margin position to constrain this space by introducing a novel metric
for history matching to binary data
The Arecibo Arp 220 Spectral Census I: Discovery of the Pre-Biotic Molecule Methanimine and New Cm-wavelength Transitions of Other Molecules
An on-going Arecibo line search between 1.1 and 10 GHz of the prototypical
starburst/megamaser galaxy, Arp 220, has revealed a spectrum rich in molecular
transitions. These include the ``pre-biotic'' molecules: methanimine
(CHNH) in emission, three direct l-type absorption lines of
HCN, and an absorption feature likely to be from either OH or formic
acid (HCOOH). In addition, we report the detection of two, possibly three,
transitions of 4-cm excited OH not previously detected in Arp~220
which are seen in absorption, and a possible absorption feature from the
6.668-GHz line of methanol. This marks the first distant extragalactic
detection of methanimine, a pre-biotic molecule. Also, if confirmed, the
possible methanol absorption line presented here would represent the first
extragalactic detection of methanol at a distance further than 10 Mpc. In
addition, the strong, previously undetected, cm-wave HCN direct
l-type lines will aid the study of dense molecular gas and active star-forming
regions in this starburst galaxy.Comment: 25 pages, 10 figures. Accepted for publication in A
Measurement of the 18Ne(a,p_0)21Na reaction cross section in the burning energy region for X-ray bursts
The 18Ne(a,p)21Na reaction provides one of the main HCNO-breakout routes into
the rp-process in X-ray bursts. The 18Ne(a,p_0)21Na reaction cross section has
been determined for the first time in the Gamow energy region for peak
temperatures T=2GK by measuring its time-reversal reaction 21Na(p,a)18Ne in
inverse kinematics. The astrophysical rate for ground-state to ground-state
transitions was found to be a factor of 2 lower than Hauser-Feshbach
theoretical predictions. Our reduced rate will affect the physical conditions
under which breakout from the HCNO cycles occurs via the 18Ne(a,p)21Na
reaction.Comment: 5 pages, 3 figures, accepted for publication on Physical Review
Letter
Adam Smith and Colonialism
In the context of debates about liberalism and colonialism, the arguments of Adam Smith have been taken as illustrative of an important line of anti-colonial liberal thought. The reading of Smith presented here challenges this interpretation. It argues that Smith’s opposition to colonial rule derived largely from its impact on the metropole, rather than on its impact on the conquered and colonised; that Smith recognised colonialism had brought ‘improvement’ in conquered territories and that Smith struggled to balance recognition of moral diversity with a universal moral framework and a commitment to a particular interpretation of progress through history. These arguments have a wider significance as they point towards some of the issues at stake in liberal anti-colonial arguments more generally
Human meniscus cells express hypoxia inducible factor-1α and increased SOX9 in response to low oxygen tension in cell aggregate culture
In previous work we demonstrated that the matrix-forming phenotype of cultured human cells from whole meniscus was enhanced by hypoxia (5% oxygen). Because the meniscus contains an inner region that is devoid of vasculature and an outer vascular region, here we investigate, by gene expression analysis, the separate responses of cells isolated from the inner and outer meniscus to lowered oxygen, and compared it with the response of articular chondrocytes. In aggregate culture of outer meniscus cells, hypoxia (5% oxygen) increased the expression of type II collagen and SOX9 (Sry-related HMG box-9), and decreased the expression of type I collagen. In contrast, with inner meniscus cells, there was no increase in SOX9, but type II collagen and type I collagen increased. The articular chondrocytes exhibited little response to 5% oxygen in aggregate culture, with no significant differences in the expression of these matrix genes and SOX9. In both aggregate cultures of outer and inner meniscus cells, but not in chondrocytes, there was increased expression of collagen prolyl 4-hydroxylase (P4H)α(I) in response to 5% oxygen, and this hypoxia-induced expression of P4Hα(I) was blocked in monolayer cultures of meniscus cells by the hypoxia-inducible factor (HIF)-1α inhibitor (YC-1). In fresh tissue from the outer and inner meniscus, the levels of expression of the HIF-1α gene and downstream target genes (namely, those encoding P4Hα(I) and HIF prolyl 4-hydroxylase) were significantly higher in the inner meniscus than in the outer meniscus. Thus, this study revealed that inner meniscus cells were less responsive to 5% oxygen tension than were outer meniscus cells, and they were both more sensitive than articular chondrocytes from a similar joint. These results suggest that the vasculature and greater oxygen tension in the outer meniscus may help to suppress cartilage-like matrix formation
Indistinguishable entangled photons generated by a light-emitting diode
A linear optical quantum computer relies on interference between photonic qubits for logic, and entanglement for near-deterministic operation. Here we measure the interference and entanglement properties of photons emitted by a quantum dot embedded within a light-emitting diode. We show that pairs of simultaneously generated photons are entangled, and indistinguishable from subsequently generated photons. We measure entanglement fidelity of 0.87 and two-photon-interference visibility of
0.60 ± 0.05. The visibility, limited by detector jitter, could be improved by optical cavity designs
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