143 research outputs found
Detrifluoroacetylation of Ethyl 2-(Ethoxymethylene)- 4,4,4-Trifluoro-3-Oxobutanoate
This work was financially supported by the Council for grants of the President of Russian Federation (grant no. MK-1453.2019.3)
Polynuclear Metallic Architectures Based on Fluorinated Functionalized Diketonates
K.Y.S. is thankful to the Council for grants of the President of Russian Federation (grant no. 1453.2019.3)
Π‘Π΅Π»Π΅ΠΊΡΠΈΠ²Π½ΡΠ΅ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΡΡ ΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»ΡΡΡΠ΅ΡΠ°Π·Ρ Π΄Π»Ρ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ, Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΠΈ ΠΈ ΡΠ°ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΡ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ², ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΡ ΡΠ»ΠΎΠΆΠ½ΠΎΡΡΠΈΡΠ½ΡΠ΅ Π³ΡΡΠΏΠΏΡ
In clinical practice, a large number of prodrugs and active drugs containing an ester, carbamate or amide moiety are used. Carboxylesterase (CaE, EC 3.1.1.1) is the key enzyme of hydrolytic metabolism of such drugs in the body, it largely determines their pharmacokinetics, bioavailability, efficacy and possible toxic effects. Using CaE selective inhibitors as components of combined drug therapy it is possible us to regulate the rate of hydrolytic transformation of ester-containing drugs and opens the possibility of their rational use. The development of effective and selective CaE inhibitors suitable for in vivo application is a new promising approach in medicinal chemistry and pharmacology that allows to improve the efficacy, bioavailability and reduce the side effects of ester-containing drugs.Π ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅ ΠΏΡΠΈΠΌΠ΅Π½ΡΠ΅ΡΡΡ Π±ΠΎΠ»ΡΡΠΎΠ΅ ΡΠΈΡΠ»ΠΎ ΠΏΡΠΎΠ»Π΅ΠΊΠ°ΡΡΡΠ² ΠΈ Π°ΠΊΡΠΈΠ²Π½ΡΡ
Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΡ
ΡΡΠ΅Π΄ΡΡΠ², ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΡ
ΡΠ»ΠΎΠΆΠ½ΠΎΡΡΠΈΡΠ½ΡΡ, ΠΊΠ°ΡΠ±Π°ΠΌΠ°ΡΠ½ΡΡ ΠΈΠ»ΠΈ Π°ΠΌΠΈΠ΄Π½ΡΡ Π³ΡΡΠΏΠΏΠΈΡΠΎΠ²ΠΊΡ. ΠΠ»ΡΡΠ΅Π²ΡΠΌ ΡΠ΅ΡΠΌΠ΅Π½ΡΠΎΠΌ Π³ΠΈΠ΄ΡΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΠ·ΠΌΠ° ΡΠ°ΠΊΠΈΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² Π² ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ΅ ΡΠ²Π»ΡΡΡΡΡ ΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»ΡΡΡΠ΅ΡΠ°Π·Ρ (ΠΠ, ΠΠ€ 3.1.1.1), ΠΊΠΎΡΠΎΡΡΠ΅ Π² Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΡΡ ΠΈΡ
ΡΠ°ΡΠΌΠ°ΠΊΠΎΠΊΠΈΠ½Π΅ΡΠΈΠΊΡ, ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΈ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΡΠ΅ ΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΡΡΠ΅ΠΊΡΡ ΡΡΠΈΡ
Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΡ
ΡΡΠ΅Π΄ΡΡΠ². ΠΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠ΅Π»Π΅ΠΊΡΠΈΠ²Π½ΡΡ
ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΡΠΎΠ² ΠΠ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ² ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΡΠ΅Π³ΡΠ»ΠΈΡΠΎΠ²Π°ΡΡ ΡΠΊΠΎΡΠΎΡΡΡ Π³ΠΈΠ΄ΡΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠ΅Π²ΡΠ°ΡΠ΅Π½ΠΈΡ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² ΡΠΎ ΡΠ»ΠΎΠΆΠ½ΠΎΡΡΠΈΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΠΎΠΉ ΠΈ ΠΎΡΠΊΡΡΠ²Π°Π΅Ρ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΠΈΡ
ΡΠ°ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ. Π‘ΠΎΠ·Π΄Π°Π½ΠΈΠ΅ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΡ
ΠΈ ΡΠ΅Π»Π΅ΠΊΡΠΈΠ²Π½ΡΡ
ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΡΠΎΠ² ΠΠ Π΄Π»Ρ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ in vivo, ΡΠ²Π»ΡΠ΅ΡΡΡ Π½ΠΎΠ²ΡΠΌ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ΠΎΠΌ Π² ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΎΠΉ Ρ
ΠΈΠΌΠΈΠΈ ΠΈ ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΠΈ, ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡΠΈΠΌ ΠΏΠΎΠ²ΡΡΠΈΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ, Π±ΠΈΠΎΠ΄ΠΎΡΡΡΠΏΠ½ΠΎΡΡΡ ΠΈ ΡΠ½ΠΈΠ·ΠΈΡΡ ΠΏΠΎΠ±ΠΎΡΠ½ΡΠ΅ ΡΡΡΠ΅ΠΊΡΡ ΠΌΠ½ΠΎΠ³ΠΎΡΠΈΡΠ»Π΅Π½Π½ΡΡ
Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΡ
ΡΡΠ΅Π΄ΡΡΠ², ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΡ
ΡΠ»ΠΎΠΆΠ½ΠΎΡΡΠΈΡΠ½ΡΠ΅ Π³ΡΡΠΏΠΏΠΈΡΠΎΠ²ΠΊΠΈ
Synthesis and tribological properties of new fluoro-containing oligomers
Oligomers based on (polyfluoroalkyl)methyl oxiranes and thiiranes was first synthesized by the cationic polymerization in the presence of boron trifluoride etherate. Molecular weights of the products were defined by cryoscopic method. It was found that synthesized oligomers can be used as additives to industrial lubricants and sulfur oligomers are of the greatest positive tribological effect. Β© Pleiades Publishing, Ltd., 2013
POLYFLUOROALKYL-2-(HET)ARYLHYDRAZONO-1,3-DICARBONYL COMPOUNDS IN INTRAMOLECULAR CYCLIZATION REACTIONS
This work was financially supported by the Program UB RAS (Grant number 18-3-3-13)
Heterometallic Molecular Architectures Based on Fluorinated Ξ²-Diketone Ligands
This review summarizes the data on the synthesis of coordination compounds containing two or more different metal ions based on fluorinated Ξ²-diketonates. Heterometallic systems are of high interest in terms of their potential use in catalysis, medicine and diagnostics, as well as in the development of effective sensor devices and functional materials. Having a rich history in coordination chemistry, fluorinated Ξ²-diketones are well-known ligands generating a wide variety of heterometallic complexes. In this context, we focused on both the synthetic approaches to Ξ²-dicarbonyl ligands with additional coordination centers and their possible transformations in complexation reactions. The review describes bi- and polynuclear structures in which Ξ²-diketones are the key building blocks in the formation of a heterometallic framework, including the examples of both homo- and heteroleptic complexes. Β© 2022 by the authors.Russian Academy of Sciences, Π ΠΠ, (AAAA-A19-119011290117-6)This work was carried out in the framework of the basic theme of the Russian Academy of Sciences (state registration β AAAA-A19-119011290117-6)
Expanding 1,2,4-triketone Toolbox for use as Aluorinated Building Blocks in the Synthesis of Pyrazoles, Pyridazinones and Ξ²-diketohydrazones
Fluorinated lithium Ξ²-diketonates bearing a methyl acetal group behave in the condensation reactions with hydrazines as trielectrophilic building blocks for the preparation of pyrazoles, pyridazinones and Ξ²-diketohydrazones. For the first time, solvent-induced regioisomeric and heterocyclic ring size-controlled formation was observed for 1,2,4-triketone analogues. Fluoroalkylated acetyl NH-pyrazoles or substituted 5-RF-pyrazoles were obtained from the acid-catalyzed cyclocondensation of lithium Ξ²-diketonates with (aryl)hydrazines in ethanol. In methanol solvent acetyl-containing 3-CF3-pyrazoles were isolated because of inverse nucleophilic attack of arylhydrazines. The use of aprotic acetonitrile in the condensation resulted in regioselective trifluorinated pyridazinones and fluorinated Ξ²-diketohydrazones formation via initial acetal fragment interaction with N,N-dinucleophile. Β© 2021 Elsevier B.V.This work carried out in the framework of the basic theme of the Russian Academy of Sciences (state registration β AAAA-A19-119011790132-7). Single-crystal X-ray diffraction analysis for 3g, 3f and 10a was performed using the equipment of the JRC PMR IGIC RAS. Single-crystal X-ray diffraction analysis for 5d, 7a, 9a and physicochemical studies were carried out using the equipments of the Center for Joint Use "Spectroscopy and Analysis of Organic Compounds" at the Postovsky Institute of Organic Synthesis UB RAS
Polyfluoroalkylated 2,3-Butanedione-Based Lithium Diketonates as Promising Building Blocks in Coordination and Heterocyclic Chemistry
Financial support from the Russian Foundation for Basic Research (grant β 18-33-20124) is gratefully acknowledged
SYNTHESIS OF FLUORINE-CONTAINING N,O-HETEROCYCLES ON THE BASE OF 4,5-BIS(TRIFLUOROMETHYL)IMIDAZOLIDINE-2-ONES, 2-AMINOETHANOL AND 2-AMINOPHENOL
This work was carried out within the framework of State task AAAA-A19-119011790132-7
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