14 research outputs found
EFFECT OF DIETARY FAT ON OBESITY AND METABOLIC SYNDROME IN SMOKERS: A CROSS-SECTIONAL STUDY
Certolizumab Pegol Treatment in Three Patients With Takayasu Arteritis
Although glucocorticoids are the mainstay of treatment in Takayasu
arteritis (TA), anti-tumor necrosis factor agents are other treatment
options in refractory disease. The onset of TA is generally observed in
females of reproductive age. Certolizumab pegol (CZP) lacks a fragment
crystallizable region and this gives advantage of minimal transfer
through the placenta, which makes CZP a safer option in pregnancy.
Although there are case reports and trials about use of infliximab,
etanercept, and adalimumab in TA, there are scarce data about use of
CZP. In this article, we present three TA cases treated with CZP. While
two patients benefited from CZP, one patient was refractory to CZP
Comorbidity and long-term outcome in patients with congenital heart block and their siblings exposed to Ro/SSA autoantibodies in utero
Importance of 14-3-3eta, anti-CarP, and anti-Sa in the diagnosis of seronegative rheumatoid arthritis
Background/aim: Rheumatoid arthritis (RA) is an autoimmune disease
characterized by synovial inflammation. The study aimed to assess serum
14-3-3eta, anti-CarP, and anti-Sa in seronegative RA (SNRA) patients who
were treatment-naive as well as in healthy subjects. This is the first
study in the literature to examine these autoantibodies together in SNRA
patients.
Materials and methods: Forty-five treatment-naive SNRA patients and 45
healthy subjects were recruited. Drugs change the levels of
autoantibodics; therefore, patients who took any medication had been
excluded from our study. Anti-carbamylated protein, anti-Sa, and
14-3-3eta were measured by using three different ELISA kits.
Results: Median serum concentration of healthy controls in 14-3-3eta was
0.02 (0.02-0.27) ng/mL. Median serum concentration of SNRA patients in
14-3-3eta was 1.00 (0.48-1.28) ng/mL. Data were analyzed with
Mann-Whitney U tests; the P-value was <0.001 in 14-3-3eta. Receiver
operating characteristic (ROC) curve analysis showed that 14-3-3eta in
SNR compared to healthy controls had a significant (P < 0.001) area
under the curve (AUC) of 0.90 (95\% confidence interval, 0.83-0.96). At
a cutoff of >= 0.33 ng/mL, the ROC curve yielded a sensitivity of
88.9\%, a specificity of 82.2\%, a positive predictive value of 83.3\%,
and a negative predictive value of 88.1\%.
Conclusion: We found that 14-3-3eta can be used as a diagnostic marker
in SNRA
FREQUENCY, CHARACTERISTICS AND CLINICAL DETERMINANTS OF ``PRODROME{''} IN FAMILIAL MEDITERRANEAN FEVER PATIENTS
Prevalence, Underlying Factors And Damage Associated With Chronic Persistent Inflammation In Patients With Fmf
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Application Of Auto-Inflammatory Disease Damage Index (Addi) To Patients With Fmf And Related Factors With Damage
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