Gate tunability of stray-field-induced electron spin precession in a GaAs/InGaAs quantum well below an interdigitated magnetized Fe grating

Time-resolved Faraday rotation is used to measure the coherent electron spin precession in a GaAs/InGaAs quantum well below an interdigitated magnetized Fe grating. We show that the electron spin precession frequency can be modified by applying a gate voltage of opposite polarity to neighboring bars. A tunability of the precession frequency of 0.5 GHz/V has been observed. Modulating the gate potential with a gigahertz frequency allows the electron spin precession to be controlled on a nanosecond timescale

The Grover algorithm with large nuclear spins in semiconductors

We show a possible way to implement the Grover algorithm in large nuclear spins 1/2<I<9/2 in semiconductors. The Grover sequence is performed by means of multiphoton transitions that distribute the spin amplitude between the nuclear spin states. They are distinguishable due to the quadrupolar splitting, which makes the nuclear spin levels non-equidistant. We introduce a generalized rotating frame for an effective Hamiltonian that governs the non-perturbative time evolution of the nuclear spin states for arbitrary spin lengths I. The larger the quadrupolar splitting, the better the agreement between our approximative method using the generalized rotating frame and exact numerical calculations.Comment: 11 pages, 18 EPS figures, REVTe

The multidimensional prognostic index (MPI) predicts long-term mortality in old type 2 diabetes mellitus patients: a 13-year follow-up study

Purpose: The Multidimensional Prognostic Index (MPI) is a tool capable of holistically frame older patients in different settings and affected by different pathologies, establishing a risk of adverse events. Among them, type 2 diabetes mellitus (T2DM), a common metabolic disease in the elderly, is responsible for complications and deaths. Few previous works have focused specifically on MPI and DM, and none have followed up the patients for more than 3&nbsp;years. The aim of the present study is to analyze MPI accuracy in predicting mortality in a cohort of T2DM patients followed-up for 13&nbsp;years. Methods: The enrolled subjects were evaluated with MPI, identifying three levels of risk: MPI1 (low risk, 0.0-0.33), MPI2 (moderate risk, 0.34-0.66), and MPI3 (severe risk, 0.67-1.0), and with glycated hemoglobin, and years since T2DM diagnosis. Results: One hundred and seven patients met the inclusion criteria. MPI3 was excluded by further analysis since it was made up of only three patients. Overall, cognitive performances, autonomies in daily living, nutritional status, risk of pressure injuries, comorbidities, and taken drugs were better (p ≤ 0.0077) in MPI1 than MPI2; moreover, the story of T2DM was shorter (p = 0.0026). Cox model showed an overall 13-year survival of 51.9%, and survival rates were significantly smaller in MPI2 (HR: 4.71, p = 0.0007). Finally, increased age (HR: 1.15), poorer cognitive abilities (HR: 1.26), vascular (HR: 2.15), and kidney (HR: 2.17) diseases were independently associated with death. Conclusion: Our results prove that MPI predicts short-, mid-, and even long-term mortality in T2DM patients, whose death seems to be related to age and cognitive status, and even more to vascular and kidney diseases

Optimized stray-field-induced enhancement of the electron spin precession by buried Fe gates

The magnetic stray field from Fe gates is used to modify the spin precession frequency of InGaAs/GaAs quantum-well electrons in an external magnetic field. By using an etching process to position the gates directly in the plane of the quantum well, the stray-field influence on the spin precession increases significantly compared with results from previous studies with top-gated structures. In line with numerical simulations, the stray-field-induced precession frequency increases as the gap between the ferromagnetic gates is reduced. The inhomogeneous stray field leads to additional spin dephasing.Comment: 4 pages, 2 figure

Two-dimensional imaging of the spin-orbit effective magnetic field

We report on spatially resolved measurements of the spin-orbit effective magnetic field in a GaAs/InGaAs quantum-well. Biased gate electrodes lead to an electric-field distribution in which the quantum-well electrons move according to the local orientation and magnitude of the electric field. This motion induces Rashba and Dresselhaus effective magnetic fields. The projection of the sum of these fields onto an external magnetic field is monitored locally by measuring the electron spin-precession frequency using time-resolved Faraday rotation. A comparison with simulations shows good agreement with the experimental data.Comment: 6 pages, 4 figure

Identification and quantification of phenolic compounds in fresh and processed table olives of cv. ‘Kalamata’

Mediterranean diet is almost synonymous to the healthy lifestyle and diet nowadays. Some of the major components of the diet are the products of the olive tree, fruits and olive oil, which are classified as medical foods, due to their nutraceutical benefits and their protective properties against cancer, cardiovascular diseases, age-related diseases, neurodegenerative disorders and other diseases. The key contributors to these properties are the phenolic compounds such as hydroxytyrosol, tyrosol and oleuropein. Table olives are being processed with several methods in order to reduce the bitterness of the olive fruit and the impact of the processing on phenolic compounds has not been studied extensively. In the present study, changes in the concentration of the most important phenolic compounds were quantified in fresh, Greek-style and Spanish-style processed olive fruits of cv. ‘Kalamata’, using two different analytical methods for identification and quantification: high-performance liquid chromatography diode array detector (HPLC-DAD) and ultrahigh-performance liquid chromatography tandem mass spectrometry (LC-(ESI)-MS/MS). The phenolic compounds that were identified and quantified were hydroxytyrosol, tyrosol, verbascocide, rutin, oleuropein and luteolin. Both processing methods used altered the phenolic compounds concentration in ‘Kalamata’ olive fruits compared to untreated fruits. In both analytical methods, a statistically significant increase in verbascoside and hydroxytyrosol concentration and a statistically significant decrease in rutin concentration was observed in both, Greek-style and Spanish-style, processed olive fruits

Variation of elastic scattering across a quantum well

The Drude scattering times of electrons in two subbands of a parabolic quantum well have been studied at constant electron sheet density and different positions of the electron distribution along the growth direction. The scattering times obtained by magnetotransport measurements decrease as the electrons are displaced towards the well edges, although the lowest-subband density increases. By comparing the measurements with calculations of the scattering times of a two-subband system, new information on the location of the relevant scatterers and the anisotropy of intersubband scattering is obtained. It is found that the scattering time of electrons in the lower subband depends sensitively on the position of the scatterers, which also explains the measured dependence of the scattering on the carrier density. The measurements indicate segregation of scatterers from the substrate side towards the quantum well during growth.Comment: 4 pages, 4 figure

Effects of Delivering Guanidinoacetic Acid or Its Prodrug to the Neural Tissue: Possible Relevance for Creatine Transporter Deficiency

The creatine precursor guanidinoacetate (GAA) was used as a dietary supplement in humans with no adverse events. Nevertheless, it has been suggested that GAA is epileptogenic or toxic to the nervous system. However, increased GAA content in rodents affected by guanidinoacetate methyltransferase (GAMT) deficiency might be responsible for their spared muscle function. Given these conflicting data, and lacking experimental evidence, we investigated whether GAA affected synaptic transmission in brain hippocampal slices. Incubation with 11.5 \ub5M GAA (the highest concentration in the cerebrospinal fluid of GAMT-deficient patients) did not change the postsynaptic compound action potential. Even 1 or 2 mM had no effect, while 4 mM caused a reversible decrease in the potential. Guanidinoacetate increased creatine and phosphocreatine, but not after blocking the creatine transporter (also used by GAA). In an attempt to allow the brain delivery of GAA when there was a creatine transporter deficiency, we synthesized diacetyl guanidinoacetic acid ethyl ester (diacetyl-GAAE), a lipophilic derivative. In brain slices, 0.1 mM did not cause electrophysiological changes and improved tissue viability after blockage of the creatine transporter. However, diacetyl-GAAE did not increase creatine nor phosphocreatine in brain slices after blockage of the creatine transporter. We conclude that: (1) upon acute administration, GAA is neither epileptogenic nor neurotoxic; (2) Diacetyl-GAAE improves tissue viability after blockage of the creatine transporter but not through an increase in creatine or phosphocreatine. Diacetyl-GAAE might give rise to a GAA\u2013phosphoGAA system that vicariates the missing creatine\u2013phosphocreatine system. Our in vitro data show that GAA supplementation may be safe in the short term, and that a lipophilic GAA prodrug may be useful in creatine transporter deficiency

Body center of mass trajectory and mechanical energy using inertial sensors: a feasible stride?

Background: The description of the three-dimensional (3D) trajectory of the body center of mass (BCoM) provides useful insights on the mechanics of locomotion. The BCoM trajectory can be estimated from ground reaction forces, recorded by force platforms (GRF, gold standard), or from marker trajectories recorded by stereophotogrammetric systems (MKR). However, both instruments do not allow for monitoring locomotion in the real-life environment. In this perspective, magneto-inertial measurement units (MIMUs) are particularly attractive being wearable, thus enabling to collect movement data out of the laboratory. Research questions: To investigate the feasibility and accuracy of a recent marketed full-body MIMU-based method for the estimation of the 3D BCoM trajectory and energetics during walking. Methods: Twelve subjects walked at self-selected and slow speed along a 12 m long walkway. GRF and MKR were acquired using three force platforms and a stereophotogrammetric system. MIMU data were collected using a full-body MIMU-based motion capture system (Xsens MTw Awinda). The 3D BCoM trajectory, external mechanical work and energy recovery were extracted from the data acquired by the three measurement systems, using state-of-the-art methods. The accuracy of both MKR- and MIMU-based estimates compared with GRF was assessed for the BCoM trajectory (maximum, minimum, range, and RMSD), as well as for mechanical work and energy recovery. Results: A total number of 108 strides were analyzed. MIMU-based BCoM trajectory displayed larger errors in comparison with GRF (and MKR) for the trajectory ranges: 89 ± 47(93 ± 44)% in antero-posterior, 46 ± 25(40 ± 79)% medio-lateral and -13 ± 23(-5 ± 25)% vertical directions, leading to a 3D RMSD of 17 ± 5(12 ± 5) mm (mean ± SD). These discrepancies largely affected the estimation of both mechanical work and energy recovery (+115 ± 85% and -28 ± 21%, respectively). Significance: Preliminary findings highlighted that the tested MIMU-based method for BCoM trajectory estimation still lacks accuracy and that the quantification of energetics in real-life situations remains an open challenge