1,169 research outputs found
Effective osimertinib treatment in a patient with discordant T790Â M mutation detection between liquid biopsy and tissue biopsy.
BACKGROUND:We report the successful treatment of the patient with osimertinib 80Â mg/day following disease progression and a discordance in the detection of a mechanism of resistance epithelial growth factor receptor (EGFR) T790Â M between liquid biopsy and tissue biopsy methods. CASE PRESENTATION:A 57-year-old Hispanic male patient initially diagnosed with an EGFR 19 deletion positive lung adenocarcinoma and clinically responded to initial erlotinib treatment. The patient subsequently progressed on erlotinib 150Â mg/day and repeat biopsies both tissue and liquid were sent for next-generation sequencing (NGS). A T790Â M EGFR mutation was detected in the blood sample using a liquid biopsy technique, but the tissue biopsy failed to show a T790Â M mutation in a newly biopsied tissue sample. He was then successfully treated with osimertinib 80Â mg/day, has clinically and radiologically responded, and remains on osimertinib treatment after 10Â months. CONCLUSIONS:Second-line osimertinib treatment, when administered at 80Â mg/day, is both well tolerated and efficacious in a patient with previously erlotinib treated lung adenocarcinoma and a T790Â M mutation detected by liquid biopsy
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