Synthesis, Characterization, and In Vivo Anti-Cancer Activity of New Metal Complexes Derived from Isatin-N(4)antipyrinethiosemicarbazone Ligand Against Ehrlich Ascites Carcinoma Cells

The current study aimed to synthesize new metal coordination complexes with potential biomedical applications. Metal complexes were prepared via the reaction of isatin-N(4)anti- pyrinethiosemicarbazone ligand 1 with Cu(II), Ni(II), Co(II), Zn(II), and Fe(III) ions. The obtained metal complexes 2–12 were characterized using elemental, spectral (1H-NMR, EPR, Mass, IR, UV-Vis) and thermal (TGA) techniques, as well as magnetic moment and molar conductance measurements. In addition, their geometries were studied using EPR and UV–Vis spectroscopy. To evaluate the in vivo anti-cancer activities of these complexes, the ligand 1 and its metal complexes 2, 7 and 9 were tested against solid tumors. The solid tumors were induced by subcutaneous (SC) injection of Ehrlich ascites carcinoma (EAC) cells in mice. The impact of the selected complexes on the reduction of tumor volume was determined. Also, the expression levels of vascular endothelial growth factor (VEGF) and cysteine aspartyl-specific protease-7 (caspase-7) in tumor and liver tissues of mice bearing EAC tumor were determined. Moreover, their effects on alanine transaminase (ALT), aspartate transaminase (AST), albumin, and glucose levels were measured. The results revealed that the tested compounds, especially complex 9, reduced tumor volume, inhibited the expression of VEGF, and induced the expression of caspase-7. Additionally, they restored the levels of ALT, AST, albumin, and glucose close to their normal levels. Taken together, our newly synthesized metal complexes are promising anti-cancer agents against solid tumors induced by EAC cells as supported by the inhibition of VEGF and induction of caspase-7

10 years of experience in adopting, implementing and evaluating progress testing for Saudi medical students

Objectives: The progress test (PT) is a comprehensive examination that is designed to match the knowledge acquisition necessary at graduation and monitors progress during the entire period of an undergraduate program. Qassim College of Medicine (QCM) began using the multi-institutional PT in the Kingdom of Saudi Arabia (KSA). This study aimed to determine if the PT can be utilized to assess the progress of medical students at different Saudi medical colleges with different educational approaches, as well as whether this testing modality could be accepted by other colleges. Methods: Beside the establishment of a PT committee, comprehensive blueprinting was crafted to sample 200 A-type multiple choice questions (MCQs) from different disciplines. The PT is a paper-and-pencil model and is answered in a 4-h period. All PT items followed a uniform design. Results: In total, 13 rounds of the progress test have been conducted. The number of participating colleges increased from three (with 285 students) in the first test (May 2012) to more than 20 (with &gt;6000 students) in the ninth round (February 2017). The average % scores for first-year students ranged from 3.0% to 7.9% while the average scores for fifth-year students ranged from 34.0% to 43.0%. Conclusion: The conduction of this meticulously crafted test to evaluate knowledge achievement at medical graduation is a fruitful tool and helps to provide constructive feedback for test-takers and other stakeholders relating to their relative positions among other fellows at the national level.</p

Gastrointestinal Stromal Tumors (GISTs), Surgical Management and Clinical Outcome

6%, 30.6%, 11.1% and 2.8%, respectively) . Almost all the cases were surgically managed and 75% were completely resectable. During follow up (average 26.5 months), 22 patients showed complete recovery, 7 had recurrent or metastatic disease and 2 died due to liver metastasis. Conclusion: The incidence of GIST in Upper Egypt is apparently low. Surgical resection is the preferred choice of treatment. The demographic data of GIST patients in South Egypt Cancer institute were similar to those published in the literature. Other prospective studies are required to assess the prognosis and the effect of treatment

Vardenafil Oral Dispersible Films (ODFs) with advanced dissolution, palatability, and bioavailability

Oral, quick response, and on demand, also known as a spontaneous oral treatment for erectile dysfunction, is highly needed by both patients and physicians. Vardenafil is selective (fewer side effects) and more effective in difficult-to-treat conditions than sildenafil. This study aims at fostering the dual objectives of using biomolecules such as artificial sweetening agents to solubilize and mask the bitterness of vardenafil loaded on biodegradable polymeric materials (PVA, MC, SA, and PVP K30) to fabricate oral, fast-dissolving films (vardenafil ODFs) in the mouth without the need for water to ingest the dosage form. Furthermore, coprecipitated-dispersed mixtures of vardenafil and three sweeteners (sorbitol, acesulfame K, and sucralose) were prepared and characterized using FTIR, DSC, and solubility studies. Moreover, eight different vardenafil ODFs were prepared using the solvent-casting method. Modified gustatory sensation test, in vitro disintegration, and release studies were performed. In addition, the optimized ODF (F8) was compared with the commercial film-coated tablets pharmacokinetically (relative bioavailability, onset, and duration of actions were estimated). The results indicated that the three sweetening agents had comparable solubilizing capacity. However, both sucralose- and acesulfame K-based ODFs have a more enhanced sweet and palatable taste than sorbitol-sweetened ODF. The SA- and PVP K30-based ODFs showed significantly faster disintegration times and release rates than MC. In conclusion, PVA has good film-forming properties, but a higher ratio of PVA adversely affected the disintegration and release characteristics. The % relative bioavailability for ODF was 126.5%, with a superior absorption rate constant (Ka) of 1.2-fold. The C(max) and estimated T(max) were compared to conventional film-coated tablets

Circular bioeconomy in Egypt: the current state, challenges, and future directions

The concept of circular bioeconomy or bio-based circular economy is an integrated concept of circular economy and bioeconomy. In other words, it alludes to a systematic approach to economic growth that makes use of cascading biomass production from biological resources. In order to fulfil the objectives of sustainable development and the circular bioeconomy in Egypt, it is recommended that the bioeconomy be focused on as an economy of societal value in this article. It also discusses future directions and actions that can be used in this regard. This paper presents the current situation of the development of circular bioeconomy in Egypt and discuss future directions and measures that can be exploited and recommends focusing on the bioeconomy as an economy of societal value, enabling the achievement of the goals of sustainable development and the circular bioeconomy. Although there is no specific strategy for the bioeconomy, there are numerous government initiatives aiming to benefit from it in the future

Effect of inorganic ions on pyrite catalyzed Fenton reaction

© 2018, Avestia Publishing. Industrial wastewaters contain not only organic pollutants but also considerable amounts of inorganic ions that may affect the efficiency of wastewater remediation processes. Thus, it is important to study the influence of such ions in the respective chemical reactions. Here we performed Fenton reactions for the decolourization of Rhodamine B dye using the naturally occurring mineral pyrite (FeS2) as heterogeneous catalyst in presence of different inorganic ions that are typically present in wastewater. Additionally, the effect of milling time of the pyrite powder on the performance of the heterogeneous Fenton reaction has also been investigated

Circular economy in Egypt: an overview of the current landscape and potential for growth

This paper provides an overview of the circular economy in Egypt. With the country facing significant environmental challenges, a circular economy approach can offer sustainable solutions to Egypt's environmental challenges by addressing issues like limited resources, waste generation, and a growing population in an eco-friendly and long-term perspective. This research employs a mixed-methods approach, including a literature review, surveys, and consultations with key stakeholders. The analysis reveals that although there are numerous challenges to establishing a circular economy in Egypt, such as limited understanding, insufficient government backing, and inadequate infrastructure, there are also opportunities, such as increasing demand for eco-friendly goods and services, as well as a receptive business environment. The paper recommends various policy and practical interventions to overcome these barriers and capitalize on these opportunities, including increasing awareness and understanding of the circular economy, developing supportive programs and regulations, investing in infrastructure and technology, and fostering stakeholder collaboration. This paper provides valuable insights into the potential for a circular economy in Egypt and the steps that can be taken to create a more sustainable future for the country. As such, it will interest policymakers, researchers, and practitioners working in the sustainability and environmental management field. The successful implementation of a circular economy in Egypt will require collective efforts from stakeholders to promote long-term sustainability and environmental stewardship

Academic Achievement and Psychosocial Profile of Egyptian Primary School Children in South Sinai

BACKGROUND: Population of South Sinai has suffered from negligence for many years. Solving educational problems of this population is the main concern nowadays.AIM: To assess academic achievement in primary school children in South Sinai in relation to intelligence and psychosocial profile.SUBJECTS AND METHODS: A descriptive cross-sectional survey was conducted on 407 Bedouin and urban students randomly selected from twelve public primary schools in six cities in South Sinai. Intelligence was assessed using Goodenough-Harris test. The midyear Arabic language and Arithmetic scores were used to assess academic achievement. The teachers completed a Pediatric-Symptom Checklist for evaluation of children behaviour.RESULTS: A statistically significant difference in academic achievement (P &lt; 0.001), total psychosocial scores, (P &lt; 0.05), and externalization (P &lt; 0.05) was found between urban and Bedouin students with significant gender differences (P &lt; 0.05). Highly significant positive correlations were observed between IQ percentile and mid-year Arabic language scores and Arithmetic scores (P &lt; 0.001), and significant negative correlations with the total score of PSCL and its subscale scores (externalising, inattention, and internalising behaviour) (P &lt; 0.001) among the students.CONCLUSION: Comorbid academic and psychosocial dysfunction in primary school children were observed in South Sinai. A national strategy to minimise the educational gap between Bedouin and urban areas should be implemented

Diabesity in the Arabian Gulf: Challenges and Opportunities

Diabesity (diabetes associated with obesity) is a major global and local public health concern, which has almost reached an epidemic order of magnitude in the countries of the Arabian Gulf and worldwide. We sought to review the lifestyle trends in this region and to highlight the challenges and opportunities that health care professionals face and attempt to address and correct them. In this regard, we aimed to review the regional data and widely held expert opinions in the Arabian Gulf and provide a thematic review of the size of the problem of diabesity and its risk factors, challenges, and opportunities. We also wished to delineate the barriers to health promotion, disease prevention, and identify social customs contributing to these challenges. Lastly, we wished to address specific problems with particular relevance to the region such as minimal exercise and unhealthy nutrition, concerns during pregnancy, the subject of childhood obesity, the impact of Ramadan fasting, and the expanding role of bariatric surgery. Finally, general recommendations for prevention, evidence-based, and culturally competent management strategies are presented to be considered at the levels of the individual, community, and policymakers