3D Woven Composites: From Weaving to Manufacturing

Manufacturing near-net shape preforms of fibre-reinforced composites has received growing interest from industry. Traditionally, a preform was made from 2D fabrics, but recently, it has been shown that 3D textiles can be used with success; with weaving being the predominant technology for carbon fibre composites. In 3D weaving, weft, warp and binder fibres run across, along and through the fabrics in the X, Y and Z directions, respectively. Producing a unitised single-piece fabric and subsequently reducing the takt time required for rapid composite manufacturing are two of the main advantages of using 3D woven preforms. Weaving of 3D fabrics, manufacturing of 3D composites, physical characterisation and mechanical testing of infused composites samples are discussed in this chapter. Finally, a large automotive composite made of single-piece 3D woven preform was manufactured and presented for demonstration

Towards Standardized, Safe and Efficacious Screening Approaches to Patients with Lower Extremity Peripheral Arterial Disease in the setting of Lower Extremity Arthroplasty

INTRODUCTION: Peripheral arterial disease (PAD) impedes recovery from lower extremity arthroplasties (LEA) and increases risk of complications/mortality, yet there aren’t standards for screening PAD patients pre-LEA. This review proposes some. METHODS: This review searched databases for articles containing relevant terms. Non-English articles, those unrelated to LEA, and duplicates were excluded. Articles were cross-referenced to find other relevant papers for a total of 111. RESULTS: Up to 49.2% of PAD patients have CAD. Wagner grade III/IV ulcers increase amputations and decrease wound closures. The Wound, Ischemia, and Foot Infection (WIfI) system provides more accurate, and therefore actionable, assessment. Overlooking PAD in surgery patients is linked to sequelae from tourniquets. Arterial calcification increases risk of perioperative blood loss from vascular compression, anemia, and critical limb ischemia. Compounding risk factors for PAD (diabetes, smoking, etc.) increase likelihood of future PAD diagnosis. If SBP\u3e180 or DBP\u3e110 mmHg, forgo elective surgery. Non-cardiac surgery patients with hypertension should receive a beta-blocker one day pre-surgery and perioperatively. Smoking cessation four weeks preoperatively and abstinence four weeks postoperatively may halve wound complications. Absent/asymmetrical pulses should prompt vascular referral pre-LEA. ABI may be falsely normal in asymptomatics with moderate aortoiliac stenosis. Risk of hematoma formation and LEA infection suggests waiting one year while continuing antiplatelet therapy. DISCUSSION/CONCLUSIONS: Adequate blood flow is imperative peri- and postoperatively for optimal healing from LEA. Before orthopedic surgery, we suggest meticulous history and assessment to identify PAD risk factors and determine tolerance for surgical intervention. Patients should be stratified for amputation risk and revascularization benefit using the WIfI system. ABI should be performed to assess severity of vascular stenosis. Patients \u3c0.9 should receive vascular consultation, then reassessment. These recommendations could help clinicians assign vascular intervention pre-LEA, minimize complications/reoperations, truncate spending, and improve patient satisfaction/well-being

The recent advances in the nanotechnology and its applications in food processing : a review.

The objectives of this paper was to discuss the latest development of nanotechnology, especially in food industries, to give clearer picture about the effect of nanotechnology in food industries and to highlight the latest applications of nanotechnology in food processing industry. However, the risk issues involving the use of nanotechnology in food were also explored. The outcome of this research revealed that the nanotechnology could be useful for controlling and manipulating the matter at the nanoscale level during processing. On the other hand, nanotechnology could also help the consumers to modify the food depending on their own nutritional needs and tastes. However, from health viewpoint, the potential risks of nanoscale materials and the possibility of the accumulation and translocation of nanoparticles in the body should be avoided

Patients with Chronic Kidney Disease and Their Quality of Life

This study aimed at exploring the assessment of Quality of Life (QOL) in patients with Chronic Kidney Disease (CKD), and aiming at assessing the QOL of patients with stages 1–5 Chronic Kidney Disease CKD on conservative treatment in order to identify a possible association between Quality Of Life QOL and progression of kidney insufficiency. The results were compared with those obtained for patients on hemodialysis. Sociodemographic, clinical and laboratory data were also evaluated. And the study concluded that research efforts have expanded significantly to determine the state of pediatric CKD patient HRQOL and the factors that impact HRQOL across all stages of CKD and all modalities of renal replacement therapy. Data from all studies suggest that children with a renal transplant fare better with respect to HRQOL than those receiving dialysis.

Seismic response analysis of linked twin tall buildings with structural coupling

Effect of structural links on seismic responses for a linked building system has been investigated in this paper by using finite element modeling technique. The linked building system in this study is represented by twin 40-story reinforced concrete frame-wall structures horizontally coupled by structural links. It is assumed that the two adjacent buildings were similar in this linked building system, so the two adjacent stories could be linked at the same height by an inter-building link. The linked building system is modeled as a rigid floor diaphragm for towers and as a beam for each link fixedly linked to the perimeter structural framework of the buildings. By employing earthquake time history excitation, the seismic responses of the twin towers were computed at different locations for the link. The responses of structures were evaluated and compared. The analysis outcomes indicated that the link could effectively change the structural responses of the linked building system. The structural responses have been decreased in some cases compared to the single tower, referring to the extra link stiffness as gathering the single tower to withstand seismic excitation. While the responses have been increased in other cases, attributing to the additional mass of link. Thus, in the design of seismic-resistant linked building systems, care must be taken. Particularly regarding properties of the link, specifically mass, stiffness, and location, as well as the link resistance with respect to the strength of the link and/or the structural elements composing the link to obviate undesired structural responses

Physiological responses of callus from gerbera jamesonii Bolus ex. Hook f. to Gamma Irradiation

In the present study, in vitro mutagenesis techniques were applied to investigate the effects of gamma irradiation at 0, 10, 20, 30, 40, 50 and 60 Gy on physiological changes in callus of Gerbera jamesonii Bolus ex. Hook f. Biochemical changes in chlorophyll and soluble protein content of pre- and post- irradiated Gerbera callus were studied. Non-irradiated callus demonstrated the highest amount of chlorophyll content as compared to callus irradiated at 10, 20, 30, 40, 50 and 60 Gy. In addition, the amount of chlorophyll b was relatively higher than chlorophyll a in both the irradiated and non-irradiated callus, except for callus irradiated at 10 Gy. Biochemical differentiation based on total soluble protein content revealed gradual reduction after day 9 of exposure to gamma irradiation. Reduction of soluble protein content was observed in all the treatments as the increase of incubation period

Association between vitamin D receptor gene polymorphisms and chronic periodontitis among Libyans

Background: Chronic periodontitis (CP) is a common oral disease characterized by inflammation in the supporting tissue of the teeth ‘the periodontium’, periodontal attachment loss, and alveolar bone loss. The disease has a microbial etiology; however, recent findings suggest that the genetic factors, such as vitamin D receptor (VDR) gene polymorphisms, have also been included.Aim: Investigation of the relationship between VDR gene polymorphisms and CP among Libyans.Materials and methods: In this study, we examined 196 unrelated Libyans between the ages of 25 and 65 years, including 99 patients and 97 controls. An oral examination based on Ramfjord Index was performed at different dental clinics in Tripoli and information were collected using a self-reported questionnaire. DNA was extracted from buccal swabs; the VDR ApaI, BsmI, and FokI polymorphisms were genotyped using polymerase chain reaction and were sequenced using Sanger Method.Results: A significant difference in the newly detected ApaI SNP C/T rs#731236 was found (p0.022), whereas no significant differences were found in ApaI SNP G/T rs#7975232, BsmI SNPA/G rs#1544410, and FokI SNP A/G rs#2228570 between patients and controls (p0.939, 0.466, 0.239), respectively.Conclusion: VDR ApaI SNP C/T rs#731236 may be related to the risk of CP in the Libyan population.Keywords: chronic periodontitis; vitamin D receptor; gene; polymorphisms; variations; SN

Divorce and Severity of Coronary Artery Disease: A Multicenter Study

The association between marital status and coronary artery disease (CAD) is supported by numerous epidemiological studies. While divorce may have an adverse effect on cardiac outcomes, the relationship between divorce and severe CAD is unclear. We conducted a multicenter, observational study of consecutive patients undergoing coronary angiography during the period between April 1, 2013, and March 30, 2014. Of 1,068 patients, 124 (12%) were divorced. Divorce was more frequent among women (27%) compared to men (6%). Most divorced patients had been divorced only once (49%), but a subset had been divorced 2 (38%) or ≥3 (12%) times. After adjusting for baseline differences, there was no significant association between divorce and severe CAD in men. In women, there was a significant adjusted association between divorce and severe MVD (OR 2.31 [1.16, 4.59]) or LMD (OR 5.91 [2.19, 15.99]). The modification of the association between divorce and severe CAD by gender was statistically significant for severe LMD (Pinteraction 0.0008) and marginally significant for CAD (Pinteraction 0.05). Among women, there was a significant adjusted association between number of divorces and severe CAD (OR 2.4 [95% CI 1.2, 4.5]), MVD (OR 2.0 [95% CI 1.4, 3.0]), and LMD (OR 3.4 [95% CI 1.9, 5.9]). In conclusion, divorce, particularly multiple divorces, is associated with severe CAD, MVD, and LMD in women but not in men

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Spectrophotometric determination of tizanidine and orphenadrine via ion pair complex formation using eosin Y

A simple, sensitive and rapid spectrophotometric method was developed and validated for the determination of two skeletal muscle relaxants namely, tizanidine hydrochloride (I) and orphenadrine citrate (II) in pharmaceutical formulations. The proposed method is based on the formation of a binary complex between the studied drugs and eosin Y in aqueous buffered medium (pH 3.5). Under the optimum conditions, the binary complex showed absorption maxima at 545 nm for tizanidine and 542 nm for orphenadrine. The calibration plots were rectilinear over concentration range of 0.5-8 μg/mL and 1-12 μg/mL with limits of detection of 0.1 μg/mL and 0.3 μg/mL for tizanidine and orphenadrine respectively. The different experimental parameters affecting the development and stability of the complex were studied and optimized. The method was successfully applied for determination of the studied drugs in their dosage forms; and to the content uniformity test of tizanidine in tablets