A Case of HeartMate 3 Outflow Graft Twisting with Extraluminal Thrombosis: Is Computed Tomography Angiography Helpful?

Twists in the outflow graft of the HeartMateTM 3 device (Abbott) have recently been described as a sporadic, late complication. We present a case with a unique combination of external compression of the HeartMate 3 outflow graft by a surgical scar compounded by thrombus formation in the space between the band relief and the outflow graft with associated twist of the outflow graft and severe flow limitation. Computed tomography angiogram (CTA) of the chest was suggestive of outflow graft thrombosis. Our case sheds additional light on the limited specificity of gated CTA in distinguishing the outflow graft twisting from thrombotic obstruction and kinking

35 - Synthesis of Tumor-Associated Carbohydrates (TACs) using Lewis Acid Catalysts

Cancer is a collection of diseases that result from uncontrolled cell division. The tumors are broadly classified as benign or malignant. Benign tumors are localized to a specific tissue, and thus, can be removed surgically with a limited chance for reoccurrence. On the other hand, malignant tumors undergo a process called metastasis to migrate to neighboring or distant tissues from the original site of occurrence. Since malignant tumors invade other tissues they are hard to detect and difficult to treat. According to the National Cancer Institute, 1.7 million cases of cancer were reported in 2014. Unfortunately, these numbers are on the rise and effective therapies against cancer are desired and extensively investigated. The tumor cells differ from normal cells with respect to certain genes, proteins and also various sugars (tumor-associated carbohydrates). The changes to the polymeric structure of the cell-surface carbohydrates upon the cancerous transformation of a cell are well-documented. These changes play a critical role in the metastasis of tumor cells. The identification of these biomarkers and their isolation or synthesis are vital to investigate methods for early diagnosis and effective treatments of cancer. The major bottleneck in advancing the research on TACs is the limited availability of these molecules in good quality and sufficient quantity. Chemical synthesis provides a solution by systematically building well-characterized molecules. However, most synthetic methods for making TACs are limited in terms of efficiency and scalability. Hence, there is a need to develop scalable & efficient protocols. Heterogeneous catalysis has a long history in synthetic chemistry and widely used industrially. This poster elaborates my efforts to develop new robust synthetic methodologies to synthesize TACs using heterogeneous Lewis acid catalysts. Keywords: Cancer, Tumor-associated carbohydrates, Chemical synthesis, Catalysi

The Magic School Bus

This report recreates the Fairey Rotodyne in modern, electric form. Extensive research into the market requirements and history of the autogiro are presented as justification for the implementation of such a design. The design criteria and mission profile are selected in order to compete with inter-city commuting in the range of 20 to 30 statute miles or with longer range travel at roughly 100 miles. Cost estimations are also made in order to gauge the feasibility of this design from an economic standpoint. Achieving the design criteria and desired mission profile are done through numerical integration and analysis through CFD to optimize the initial design detailed below. The results that we found show that this is a feasible design worthy of further investigation

Spontaneous coronary artery dissection: a rare diagnosis in a postmenopausal woman

We report a case of a 50-year-old ex-smoker, postmenopausal woman presenting with an acute myocardial infarction caused by a spontaneous coronary artery dissection of a long ‘wrap-around’ left anterior descending coronary artery. After the diagnostic coronary angiography, she was treated medically with subsequent improvement

Comparing outcomes of ultra-low-cost hearing aids to programmable, refurbished hearing aids for adults with high frequency hearing loss in Malawi : a feasibility study

DATA AVAILABILITY STATEMENT : The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.INTRODUCTION : Access to ear and hearing health services are limited or non-existent in low-income countries, with less than 10% of the global production of hearing aids distributed to this population. The aim of this feasibility study was to compare the outcomes of an ultra-low-cost hearing aid (LoCHAid) to programmable, refurbished hearing aids for adults with high-frequency hearing loss, in Blantyre, Malawi. METHODS : Sixteen adults with high frequency hearing loss, and no prior experience of hearing aids, took part in this study, nine were fitted with the LoCHAid and seven were fitted with refurbished, programmable hearing aids, for a one-month trial. Five standardized hearing qualities questionnaires were used to compare outcomes pre and post device fitting and between devices. Questionnaire scales were analysed using general linear models and inductive thematic analysis was used to evaluate qualitative data. RESULTS : Overall, there was no significant difference found between LoCHAid and refurbished hearing aids, and the two device types each showed a similar degree of improvement after fitting. Qualitative data analysis identified two key themes: Sound Quality and User experience. CONCLUSION : The results from this feasibility study are encouraging, but a comprehensive, larger clinical study is needed to draw firm conclusions about the LoCHAid’s performance. This study has identified key improvement indicators required to enhance sound quality and user experience of the LoCHAid.The Disability Impact Fund, the National Institute of Health Research (NIHR) Programme grant for Applied Research, the Biomedical Research Centre, Microsoft's AI for Accessibility program and the Open Philanthropy Project.https://www.frontiersin.org/journals/rehabilitation-sciencesam2024Speech-Language Pathology and AudiologySDG-03:Good heatlh and well-bein

56. Synthesis of Tumor-Associated Carbohydrates Using Lewis Acid Catalysts

Cancer is a collection of diseases that result from uncontrolled cell division to form tumorous tissue. Benign tumors are localized to a specific part and can be removed surgically. However, malignant tumors undergo a process called metastasis to migrate to neighboring or distant tissues from their original site of occurrence. Since malignant tumors invade other tissues they are hard to detect and difficult to treat. According to the National Cancer Institute, 1.7 million cases of cancer were reported in 2014. Unfortunately, these numbers are on the rise and effective therapies against cancer are desired and extensively investigated. The tumor cells differ from normal cells with respect to certain genes, proteins and also various sugars (tumor-associated carbohydrates). The changes to the polymeric structure of the cell-surface carbohydrates upon malignant transformation are well-documented. These changes play a critical role in the metastasis of tumor cells. The identification of these biomarkers and their isolation or synthesis are vital to investigate methods for early diagnosis and effective treatments of cancer. A major hurdle in advancing the research on TACs is the limited availability of these molecules in good quality and sufficient quantity. Chemical synthesis provides a solution by systematically building well-characterized molecules. However, most synthetic methods for making TACs are limited in terms of efficiency and scalability. Hence, there is a need to develop scalable & efficient protocols. Heterogeneous catalysis has a long history in synthetic chemistry and widely used industrially. These catalysts can be engineered to install sugars on amino acid sidechains in specific orientations. We have tested and compared different Lewis acids with commercially available glucose- and galactose-pentaacetate. Zirconium sulfate showed the cleanest results in model reaction systems. This poster highlights our continued efforts on screening more Lewis acids and their selectivity in installing these sugars on serine and threonine amino acids