Exercise interventions for weight management during pregnancy and up to 1 year postpartum among normal weight, overweight and obese women: a systematic review and meta-analysis

Background: The prevalence of excessive gestation weight gain, extended postpartum weight retention and pre-gravid obese women is increasing and is associated with numerous adverse health outcomes. Objective To review the evidence from studies employing exercise-only interventions for weight management among pregnant and postpartum women. Search strategy Ten databases were searched for randomised controlled trials (RCTs) conducted during pregnancy or within the 12 month following childbirth and published between 1990 and 2013. Selection criteria: There were no restrictions to the type, frequency, duration or intensity of exercise intervention. Interventions not specifically designed to target weight were excluded. The outcomes were a change in body weight (kg) or body mass index (BMI; kg·m2). Data collection and analysis: All data were continuous and were reported as weighted mean differences (WMD), with 95% confidence intervals (CI). Data were analysed with a fixed-effect model and heterogeneity was determined using the I2 statistic. Results: Five studies were included in this review. Exercise significantly reduced gestational weight gain (WMD=-2.22kg, CI=-3.14/-1.3, p=<0.00001) and had no significant effect on postpartum weight loss (WMD=-1.74kg, CI=-3.59/0.10, p=0.06) or BMI during pregnancy (WMD=-2.8kg·m2, CI=-5.60/0.00, p=0.05) or postpartum (WMD=-0.54kg·m2, CI=-1.17/0.08, p=0.09). Conclusions: There is currently limited evidence to suggest that exercise can be used to limit maternal gestational weight gain

Reduced energy availability: implications for bone health in physically active populations

Purpose: The present review critically evaluates existing literature on the effects of short- and long-term low energy availability (EA) on bone metabolism and health in physically active individuals. Methods: We reviewed the literature on the short-term effects of low EA on markers of bone metabolism and the long-term effects of low EA on outcomes relating to bone health (bone mass, microarchitecture and strength, bone metabolic markers and stress fracture injury risk) in physically active individuals. Results: Available evidence indicates that short-term low EA may increase markers of bone resorption and decrease markers of bone formation in physically active women. Bone metabolic marker responses to low EA are less well known in physically active men. Cross-sectional studies investigating the effects of long-term low EA suggest that physically active individuals who have low EA present with lower bone mass, altered bone metabolism (favouring bone resorption), reduced bone strength and increased risk for stress fracture injuries. Conclusions: Reduced EA has a negative influence on bone in both the short- and long-term, and every effort should be made to reduce its occurrence in physically active individuals. Future interventions are needed to explore the effects of long-term reduced EA on bone health outcomes, while short-term low EA studies are also required to give insight into the pathophysiology of bone alterations

What Counts as Fraud? An Empirical Study of Motions To Dismiss Under the Private Securities Litigation Reform Act

This article presents the findings of a study of the resolution of motions to dismiss securities fraud lawsuits since the passage of the Private Securities Litigation Reform Act in 1995. Our sample consists of decisions on motions to dismiss in securities class actions by district and appellate courts in the Second and Ninth Circuits for cases filed after the passage of the Reform Act to the end of 2002. These circuits are the leading circuits for the filing of securities class actions and are generally recognized as representing two ends of the securities class action spectrum. Post-PSLRA, the Second Circuit applies the least restrictive pleading standard to securities claims and the Ninth Circuit applies the most restrictive. The Ninth Circuit’s post-PSLRA reputation as being a tougher venue in which to win securities fraud class actions is born out by a significantly higher dismissal rate. The differences between the two circuits are also reflected in factors that correlate with dismissal. For example, allegations of violations of accounting principles other than revenue recognition correlate negatively with dismissal in the Second Circuit. This coefficient, however, is insignificant in our regressions for the Ninth Circuit. Allegations of revenue recognition violations are insignificant in both circuits, whether or not the issuer has been forced to restate those revenues. The circuits part ways on other factors as well: the Second Circuit is significantly less likely to dismiss cases with allegations of false forward-looking statements, a surprising result given the stringent standards for such statements imposed by the PSLRA. The Ninth Circuit is significantly less likely to dismiss complaints with allegations of ’33 Act violations and the Second Circuit is more likely to dismiss cases brought by the Milberg Weiss firm. When it comes to insider trading, however, the two circuits are both skeptical and the allegations correlate with dismissal in both circuits

What Counts as Fraud? An Empirical Study of Motions To Dismiss Under the Private Securities Litigation Reform Act

This article presents the findings of a study of the resolution of motions to dismiss securities fraud lawsuits since the passage of the Private Securities Litigation Reform Act in 1995. Our sample consists of decisions on motions to dismiss in securities class actions by district and appellate courts in the Second and Ninth Circuits for cases filed after the passage of the Reform Act to the end of 2002. These circuits are the leading circuits for the filing of securities class actions and are generally recognized as representing two ends of the securities class action spectrum. Post-PSLRA, the Second Circuit applies the least restrictive pleading standard to securities claims and the Ninth Circuit applies the most restrictive. The Ninth Circuit’s post-PSLRA reputation as being a tougher venue in which to win securities fraud class actions is born out by a significantly higher dismissal rate. The differences between the two circuits are also reflected in factors that correlate with dismissal. For example, allegations of violations of accounting principles other than revenue recognition correlate negatively with dismissal in the Second Circuit. This coefficient, however, is insignificant in our regressions for the Ninth Circuit. Allegations of revenue recognition violations are insignificant in both circuits, whether or not the issuer has been forced to restate those revenues. The circuits part ways on other factors as well: the Second Circuit is significantly less likely to dismiss cases with allegations of false forward-looking statements, a surprising result given the stringent standards for such statements imposed by the PSLRA. The Ninth Circuit is significantly less likely to dismiss complaints with allegations of ’33 Act violations and the Second Circuit is more likely to dismiss cases brought by the Milberg Weiss firm. When it comes to insider trading, however, the two circuits are both skeptical and the allegations correlate with dismissal in both circuits

Day 1. Posters – Sport and Performance

Background: Exercise tests are one of the most commonly used tools within sports science research. Therefore, the reliability of such exercise tests is of critical importance when investigating the efficacy of nutritional, physiological, psychological or training interventions. Purpose: The aim of this experiment was to measure the reliability of a 20 km cycling time trial performance test when performed by mounting the cyclists own bicycle frame on an electronic turbo trainer. Methods: Twenty one male cyclists (age 35 ± 8 y, height 1.82 ± 0.05 m, body mass 80.7 ± 9.0 kg) completed the 20 km time trial on three separate occasions; the initial visit was a habituation trial and was followed by two main trials. All laboratory visits were conducted at the same time of day, following a 24h diet and activity standardisation period, and at least 2 h postprandial. The time trial was completed on a Cyclus2 (RBM Electronic, Germany) ergometer. The cyclists mounted their own bike frames on to the ergometer and the settings on the Cyclus2 were adjusted for each individual bike, ensuring an accurate measurement of distance and performance. During the exercise trial, participants were deprived of any performance information other than distance covered and gear selection; no encouragement was provided by experimenters. Results: There was no order effect of the trials, inclusive of the habituation trial (p = 0.901). There was no significant difference in the time taken to complete the 20 km between trials 1 and 2 (trial 1: 1969 ± 112 s; trial 2: 1975 ± 119 s; p = 0.222). The intra-class correlation between trial 1 and 2 was r = 0.99, with the coefficient of variation being 0.7%. Conclusions: The use of a 20 km cycling time trial, in which the cyclists bicycle frame is mounted on a cycle ergometer, is highly reproducible. Such a test can, therefore, be reliably used to detect changes in performance due to various interventions

What Counts as Fraud? An Empirical Study of Motions to Dismiss Under the Private Securities Litigation Reform Act

This article presents the findings of a study of the resolution of motions to dismiss securities fraud lawsuits since the passage of the Private Securities Litigation Reform Act (PSLRA) in 1995. Our sample consists of decisions on motions to dismiss in securities class actions by district and appellate courts in the Second and Ninth Circuits for cases filed after the passage of the Reform Act to the end of 2002. These circuits are the leading circuits for the filing of securities class actions and are generally recognized as representing two ends of the securities class action spectrum. Post-PSLRA, the Second Circuit applies the least restrictive pleading standard to securities claims and the Ninth Circuit applies the most restrictive. The Ninth Circuit\u27s post-PSLRA reputation as being a tougher venue in which to win securities fraud class actions is borne out by a significantly higher dismissal rate. The differences between the two circuits are also reflected in factors that correlate with dismissal. For example, allegations of violations of accounting principles other than revenue recognition correlate negatively with dismissal in the Second Circuit. This coefficient, however, is insignificant in our regressions for the Ninth Circuit. Allegations of revenue recognition violations are insignificant in both circuits, regardless of whether the issuer has been forced to restate those revenues. The circuits part ways on other factors as well: the Second Circuit is significantly less likely to dismiss cases with allegations of false forward-looking statements, a surprising result given the stringent standards for such statements imposed by the PSLRA. The Ninth Circuit is significantly less likely to dismiss complaints with allegations of \u2733 Act violations, and the Second Circuit is more likely to dismiss cases brought by the Milberg Weiss firm. When it comes to insider trading, however, both circuits are skeptical, and the allegations correlate with dismissal in both circuits

A pilot study evaluating the effects of a 12 week exergaming programme on body mass, size and composition in postpartum females

Introduction: Pregnancy is associated with weight gain, the retention of which contributes to the prevalence of obesity and overweight in adult females. Many new mothers do not achieve the recommendations for physical activity (PA), citing factors such as a lack of time and access to childcare. Exergaming may address some of the barriers to PA and offer an alternative to traditional exercise, thus aiding in weight management. The aim of this pilot study was to evaluate the effects of an exergaming intervention on body composition in postpartum females. Methods: Eight females who had given birth within 1 year completed a 12 week exergaming intervention, which required them to exercise at home for 45 minutes on alternate days, using the Wii Fit. Participants self-reported their pre-pregnancy body weight, and visited the laboratory prior to and following the intervention for evaluation of body weight, size (height, regional circumferences, body mass index [BMI]) and composition (fat mass [FM], lean mass [LM] and bone mineral content [BMC]). Body composition was evaluated via full body full-body dual-energy x-ray absorptiometry scan. Participants completed a three-day weighed food intake at three time-points. Results: Baseline body mass was 8.2 kg greater than self-reported pre-pregnancy values (56.8 ± 5.1 kg). Following the intervention, body mass was significantly lower than baseline values and was similar to pre-pregnancy levels (59.9 ± 7.9 kg). Reductions in BMI (~2 kg·m2 ), waist, hip and bust circumference (3-6%) accompanied the loss of body mass. Food diaries confirmed participants had not altered their energy intake. Discussion: The results of this pilot study indicate that exergaming may offer an alternative to traditional exercise for preventing the retention of gestational weight gain and reducing associated health risks, whilst also maintaining lean mass and bone mineral content

Corporate Adolescence: Why Did “We” Not Work?

This article explores a series of rent-seeking behaviors and fiduciary deficits that are playing a role in the “growth” and demise of U.S. companies. Start-up financing occurs through exemptions that remove disclosure obligations required in public markets, assuming that private ordering suffices. The exemptive-privilege premise is that parties to financing rounds will be faithful agents, i.e., fiduciaries, to their sources of capital. Where there are conflicts of interest, fiduciary deficits will arise unless either the threat of litigation for breaches of duty sufficiently deters the resulting opportunism or the sources of capital are themselves sufficiently watchful and savvy to combat the opportunism. As private capital sources become more numerous and diverse, the latter may not happen so reliably. We examine this territory through a business-school like case study of WeWork, one of the most recent examples of failed private ordering and one where the prescribed corporate governance mechanisms failed to fill the gaps. WeWork’s extraordinary growth over eight rounds of financing both strengthened the hand of its CEO, Adam Neumann and concealed danger signs. Indeed, in the absence of required disclosure, fiduciary duties take on extra significance. Yet, the WeWork board exhibited multiple fiduciary deficits resulting in what is a cautionary story about governance failure and a warning to those who are focused on expanding “access” to these funding rounds In short, the funding and governance systems are not designed for long-term “startup” governance, and WeWork reveals the systemic slack and flaws. Our exploration of the motivations, incentives and opportunities in start-up financing reveals an accumulating set of deficits that makes the current state of affairs more problematic than the conventional account would suggest. From founder control enabling self-centered, biased and risky behaviors, to funders with diverse incentives and capital sources, to start-up market “valuations” issues, the result is failed information-forcing systems and governance safeguards and directors who focus on constituent protections and not on their fiduciary duties

Effects of reduced energy availability on bone metabolism in women and men

Background: The short-term effects of low energy availability (EA) on bone metabolism in physically active women and men are currently unknown. Purpose: We evaluated the effects of low EA on bone turnover markers (BTMs) in a cohort of women and a cohort of men, and compared effects between sexes. Methods: These studies were performed using a randomised, counterbalanced, crossover design. Eleven eumenorrheic women and eleven men completed two 5-day protocols of controlled (CON; 45 kcal·kgLBM-1.d-1) and restricted (RES; 15 kcal.kgLBM-1·d-1) EAs. Participants ran daily on a treadmill at 70% of their peak aerobic capacity (VO2 peak) resulting in an exercise energy expenditure of 15 kcal·kgLBM-1·d-1 and consumed diets providing 60 and 30 kcal·kgLBM-1·d-1. Blood was analysed for BTMs [β-carboxyl-terminal cross-linked telopeptide of type I collagen (β-CTX) and amino-terminal propeptide of type 1 procollagen (P1NP)], markers of calcium metabolism [( parathyroid hormone (PTH), albumin-adjusted calcium (ACa), magnesium (Mg) and phosphate (PO4)] and regulatory hormones [sclerostin, insulin-like growth factor 1 (IGF-1), triiodothyronine (T3), insulin, leptin, glucagon-like- peptide-2 (GLP-2)]. Results: In women,β-CTX AUC was significantly higher P=0.03) and P1NP AUC was significantly lower (P=0.01) in RES compared to CON. In men, neither β-CTX (P=0.46) n or P1NP (P=0.12) AUCs were significantly different between CON and RES. There were no significant differences between sexes for any BTM AUCs (all P values>0.05). Insulin and leptin AUCs were significantly lower following RES in women only (for both P=0.01). There were no differences in any AUCs of regulatory hormones or markers of calcium metabolism between men and women following RES (all P values>0.05). Conclusions: When comparing within groups, five days of low EA (15 kcal·kgLBM-1·d-1) decreased bone formation and increased bone resorption in women, but not in men, and no sex specific differences were detected

Parathyroid hormone secretion is controlled by both ionised calcium and phosphate during exercise and recovery in men

The mechanism by which PTH is controlled during and after exercise is poorly understood due to insufficient temporal frequency of measurements. Objective: To examine the temporal pattern of PTH, PO4, ACa and Ca2+ during and after exercise. Design and setting: A laboratory-based study with a cross-over design, comparing 30 min of running at 55%, 65% and 75%VO2max, followed by 2.5-h of recovery. Blood was obtained at baseline, after 2.5, 5, 7.5, 10, 15, 20, 25 and 30 min of exercise and after 2.5, 5, 7.5, 10, 15, 20, 25, 30, 60, 90 and 150 min of recovery. Participants: Ten men (age 23±1 y, height 1.82±0.07 m, body mass 77.0±7.5 kg) participated. Main Outcome Measures: PTH, PO4, ACa and Ca2+ Results: Independent of intensity, PTH concentrations decreased with the onset of exercise (-21 to -33%; P≤0.001), increased thereafter and were higher than baseline by the end of exercise at 75%VO2max (+52%; P≤0.001). PTH peaked transiently after 5–7.5 min of recovery (+73 to +110%; P≤0.001). PO4 followed a similar temporal pattern to PTH and Ca2+ followed a similar but inverse pattern to PTH. PTH was negatively correlated with Ca2+ across all intensities (r=-0.739 to -0.790; P≤0.001). When PTH was increasing, the strongest cross-correlation was with Ca2+ at 0 lags (3.5 min) (r=-0.902 to -0.950); during recovery, the strongest cross-correlation was with PO4 at 0 lags (8 min) (r=0.987 to 0.995). Conclusions: PTH secretion during exercise and recovery is controlled by a combination of changes in Ca2+ and PO4 in men