Design, Modeling and Performance Investigation of GC PVGS

This paper proposes a new topology for the power injection system that is based on the parallel association of two voltage source inverters: one is operated using a quasi-square voltage waveform strategy and the other operates with a PWM based strategy. The aim of this topology is that the quasi-square inverter injects the power from the photovoltaic generation system and the PWM inverter controls the current quality. The proposal optimizes the system design, permitting reduction of system losses and an increase of the energy injected into the grid. Keywords: quasi square wave inverter, pulse width Modulation inverter, photo voltaic power system, modulation Index (M)

TARGETED THERAPY FOR BREAST CANCER CELLS BY HERBAL DRUG FORMULATIONS OF IRON OXIDE NANOPARTICLES

Nanoparticle based drug delivery is the currently focused area in case of various therapeutic and diagnostic techniques. Iron oxide nanoparticles are used as carriers in drug delivery due to their unique properties and negligible side effects. We analyze the potential therapeutic properties of methanolic extracts of Centella asiatica loaded with PVP iron oxide nanoparticles against human breast cancer cell lines MCF-7 and the results were compared with normal cell lines. Characterization of coated nanoparticles was done by UV-VIS spectroscopy, FTIR spectroscopy and Particle size analyzer. Loading of herbal drug extract to nanoparticles was confirmed using TEM, Particle size analyzer, FTIR and Biochemical assays. Initially, dose depended hydrogen per oxide free radical scavenging activity were recorded. Methanolic extracts of Centella asiatica showed 55, 59, 71 and 80% inhibition respectively. MTT assay was performed to estimate the drug loading efficiency for PVP coated iron oxide nanoparticle at 1hr and 24 hrs. At 10µl concentration methanolic extracts of Centella asiatica loaded PVP coated iron oxide nanoparticles exhibited significant cell necrosis in breast cancer cell line MCF-7 as 60%. In case of normal cell lines L929, the cytotoxicity was reduced to 10.42 respectively. This work was aimed to increase the efficiency, reduce side effects of chemotherapeutic drugs and provide conveniences for the future therapeutics by coupling herbal drug with polymer coated nanoparticles.Â

HYDROGEOCHEMICAL QUALITY OF GROUNDWATER IN PERUMAL LAKE, KURINJIPADI TALUK, CUDDALORE DISTRICT, TAMILNADU, INDIA

A study was carried out to determine the groundwater quality in parts of Perumal Lake, Kurinjipadi Taluk, Cuddalore district, Tamilnadu. Totally, 12 groundwater samples were collected at different parts of study area and 16 water samples from surface reservoirs (Perumal lake) and analyzed for physicochemical parameters (pH, EC, TDS, TH, Na, K, Ca, Mg and Cl, SO4 , HCO3- , NO3 ) in order to understand the hydro geochemistry of the water. The results of analysis were interpreted with geology and geomorphology of the area and also by various geochemical diagrams such as Piper trilinear plot and USSL classification diagram. Suitability of this water for its utility was verified using Indian standards. The result indicates irrespective of the seasons that only one well is suitable for drinking purpose, with remaining suitable for domestic and irrigation purpose. Further, from the results, it is pointed out that most of the well water falls in Na-Cl type indicating the influence of seawater in these wells which was confirmed by Piper plot. According to SAR (alkali hazard) and specific conductance (Salinity hazard) is plotted in USSL diagram, classification of water for irrigation purpose can be determined. Majority of groundwater samples fall in C3S1 zone indicating high salinity and low sodium hazard, satisfactory for plants having moderate salt tolerance on soils. In surface water most of the samples fall in C2S1 indicates medium salinity and low sodium hazard

प्रजाति विविधीकरण – तटीय जलकृषि में स्थिरता सुनिश्चित करने का उपाय

कृपया पूरा लेखा पढ

Cage Farming of Cobia Rachycentron canadum

Cobia has gained popularity as a good candidate for mariculture due to its rapid growth and white meat of versatile use. It is considered as one of the most promising candidates for warm-water marine fish aquaculture in the world. Being the only member of the family Rachycentridae, it is found in the warm, temperate to tropical waters of the West and East Atlantic, throughout the Caribbean and in the Indo-Pacific off India, Australia and Japan. To date, research and development of cobia aquaculture has been initiated in over 23 countries and territories

Analysis of multiparametric MRI data in prostatic carcinoma- PI-RADS and correlation with gleason score in a 3T MRI

INTRODUCTION: Carcinoma of prostate is one of the leading causes of cancer death among aged men. Most of the prostate cancers are slow-growing and indolent rather than being aggressive. Hence, early diagnosis of prostate cancer can lead to improved treatment outcomes. MP-MRI aids in pre-biopsy diagnosis of cancer prostate. It also helps in characterizing the extent of disease involvement which can aid in minimally-invasive procedures. AIM & OBJECTIVES: AIM: To evaluate the efficacy of Multipara metric MRI as a noninvasive investigation in detection of carcinoma prostate in patients with raised PSA level and to correlate PI-RADS with Gleason‘s score. OBJECTIVES: 1. To correlate apparent diffusion coefficient (ADC) values with Gleason‘s score of prostate cancer. 2. To determine mean ADC values for low risk (Gleason‘s score 7) prostate cancer. MATERIALS & METHODS: Study Design: Prospective observational study. Sample Size: 25 males, age between 50 and 78 years with raised PSA levels. Methods: All 25 patients were subjected for the MP-MRI sequences. The machine used in this study is SIEMENS 3.0 Tesla MRI (Skyra, Erlangen Germany).The prostate imaging- reporting and data system (PI-RADS) scoring involves 4 components- T2w-MRI, DWI-MRI, DCE-MRI and MR spectroscopy to classify the risk of malignancy. The total score is 20. Gleason‘s score was obtained by histopathologic analysis. RESULTS: According to MP-MRI based PI-RADS scoring, 44% of patients had highly suspicious malignancy, 44% had probably malignant lesion while 12% had indeterminate lesions. Out of 25 patients subjected for TRUS biopsy, 6 patients reported a Gleason score of 6, 8 reported a Gleason score of 7 and 11 patients reported a Gleason score of 8 & above indicating in favor of Malignancy. There was a positive linear correlation between PIRADS and Gleason score (+0.790), p value <0.001. There was a significant negative correlation between mean tumor ADC values and Gleason‘s score, – 0.912, p value <0.001. CONCLUSION: Based on the findings of this study, it can be concluded that there is a significant positive correlation between PI-RADS and Gleason’s score & a negative correlation between mean tumor ADC value and Gleason’s score. Thereby, PI-RADS can noninvasively assess the aggressiveness of prostate cancer. Also, the mean tumor ADC value could differentiate between low, intermediate and high grade tumors. Thus incorporation of ADC values in MP-MRI could avoid surgery in patients with indolent tumor, for whom the potential risk of surgery outweighs the survival benefit

Farming of Silver Pompano Trachinotus blochii in coastal aquaculture ponds

The Central Marine Fisheries Research Institute has initiated aquaculture research on pompano from 2008 and the first successful broodstock development, induced breeding and larval production was achieved in 2011. Following the successful seed production of silver pompano, demonstration of farming in brackishwater ponds was initiated by the CMFRI to popularize among the farmers about its suitability for aquaculture. The first farming demonstration from the hatchery produced seed was carried out in a coastal aquaculture pond at Anthervedi Village, East Godavari District, Andhra Pradesh. It has been proven that silver pompano can be cultured in the brackishwater shrimp culture ponds as an alternative species with high survival rate, appreciable FCR and meat quality. These fishes have attained an average weight of 450 grams in 240 days (8 months). Based on the experience gained on the brackishwater farming of silver pompano, the practices to be adopted for pompano farming are narrated

Hormonal induction of spawning in marine finfishes

In recent years, especially with the development and expansion of sea cage farming, mariculture is growing rapidly. On a global basis, a rapid growth in marine finfish culture is noted. It has increased at an annual average growth rate of 9.3% from 1990 to 2010. Salmonids, amberjacks, sea breams, sea basses, croakers, groupers, drums, mullets, turbot, other flatfishes, snappers, cobia, pompano, cods, puffers and tunas are the major groups which are maricultured

Biotechnological interventions in marine finfish breeding and seed production

Fish farming is the world’s fastest growing sector of agricultural business. Fish and other aquatic products represent an important, underutilized resource for a protein-hungry world. Natural catches are dropping even as demand continues to increase, making aquaculture increasingly attractive. Consumer demand for fish products is increasing. At the same time, wild fish stocks are rapidly declining, mainly because of over fishing. Biotechnology provides powerful tools for the sustainable development of aquaculture, fisheries, as well as the food industry. Increased public demand for seafood and decreasing natural marine habitats have encouraged scientists to study ways that biotechnology can increase the production of marine food products, and making aquaculture as a growing field of animal research