Differences between living and deceased donation in human uterus transplantation: A narrative review

Abstract The decision to use a living or deceased donor to perform uterus transplantation (UTx) is an evaluation of benefit and harm and is based on the medical team's choices. The current study determines the differences between living and deceased donation in human UTx according to determinant factors in choosing the donor type. For this review study, the PubMed database was searched without time, language, and location limitations up to May 2022. From 113 identified articles, 45 papers were included in the study for review. According to the results, in comparison to living donation, the biggest advantage of deceased donation is the lack of surgical and or psychological risks for the donor. In contrast, a comprehensive pre-transplantation medical assessment is less possible in deceased donation, and preplanned surgery cannot be realized. According to published peer-reviewed clinical trials on UTx, the graft failure rates in living and deceased donor UTx are 21% and 36%, respectively. Supposing all recipients who did not have graft failure underwent embryo transfer, live birth rates in living and deceased donor UTx procedures are almost 63% and 71%, respectively. Currently, considering the occurrence of live births from both donations, particularly from nulliparous deceased donor, increased demand for UTx in the near future, shortage of uterus grafts, and lack of sufficient data for a comprehensive comparison between the 2 types of donation, the use of both donations still seems necessary and rational

Prevalence, risk factors and molecular evaluation of hepatitis E virus infection among pregnant women resident in the northern shores of Persian Gulf, Iran.

Although Iran is reported to be an endemic country for hepatitis E virus (HEV), data on the prevalence of HEV infection among pregnant women are scarce and the epidemiology of HEV is unknown in most parts of the country. Therefore, this study was conducted to elucidate the prevalence, risk factors and genotypic pattern of HEV infection among pregnant women resident in the northern shores of Persian Gulf. This is the first report on the epidemiology of HEV infection among pregnant women in this territory.From October 2016 to May 2017, 1331 pregnant women participated in this study. The mean age ± SD of participants was 27.93±5.7 years with a range of 14-45 years. Serum samples of pregnant women were screened for the presence of anti-HEV total antibodies, anti-HEV IgG and anti-HEV IgM using commercially available ELISA kits (DIA.PRO, Milan, Italy). All anti-HEV IgG and anti-HEV IgM positive samples were tested for HEV RNA using two independent reverse transcriptase polymerase chain reaction (RT-PCR) assays, targeting ORF2 and ORF3 of HEV genome. In addition, 92 anti-HEV seronegative samples as well as 50 pooled seronegative samples were evaluated by two independent RT-PCR assays for validation of results.Of the 1331 pregnant women, 84 women (6.3%, 95% CI: 5.1%-7.7%) were positive for anti-HEV antibodies, of which 83 women had anti-HEV IgG, and 11 women (0.83%, 95% CI: 0.47%-1.47%) had anti-HEV IgM. The highest rate of HEV seroprevalence was observed among Afghan immigrants (68.0%), uneducated pregnant women (46.51%) and those residents in Bushehr city (8.75%). All anti-HEV IgG and/or IgM positive samples were found to be negative for HEV RNA. In addition, all of the evaluated anti-HEV seronegative samples were negative for HEV RNA. HEV seropositivity among pregnant women was statistically associated with age, ethnicity, place of residence, number of pregnancies, and level of education. So that, low education levels, Afghan, residence in Bushehr city, age group >34 years, and more parities were risk factors for exposure to HEV. In contrast, HEV seropositivity was not associated with stage of gestation, history of abortion, and time of sampling.The northern shores of Persian Gulf in Iran, with HEV seroprevalence of 6.3%, can be classified as an endemic geographical region for hepatitis E, and residents of Bushehr city, Afghan immigrants and uneducated women are the main at-risk populations in this territory

Iranian Women’s Experiences with Intimate Partner Violence: A Qualitative Study

Background: Violence against women has been identified as a public health problem, which has fundamental consequences on women's physical, mental, and reproductive health. To understand abused women and provide support for them, it is necessary to enter the world in which the victims of intimate partner violence live. This study was designed to investigate experiences of abused Iranian women of intimate partner violence. Methods: Content analysis approach was used to design this qualitative study. Participants were 11 married women, selected from two health centers and one park located in the south of Tehran, Iran. Purposive sampling method was applied to recruit the study participants and continued until data saturation was reached. Semi-structured interviews were employed to collect data. Results: During the data analysis, 650 initial codes were clustered in six subcategories and two categories. “Neglect or covert violence” and “overt violence” were two categories emerged through data analysis, both having physical, sexual, and emotional dimensions. Emotional violence was the most prevalent in both cases and had more significance for the women. Neglect was much more common than overt violence. It was the precursor for overt violence. Conclusion: Although participants had experienced both neglect and overt violence, the major part of experienced violence was neglect. This type of violence usually is not addressed or recognized and is difficult to identify, but it is damaging to women. Knowledge of women‟s experiences of intimate partner violence makes the health staff provide better care for abused women

Prevalence of anti-HEV IgM among pregnant women according to socio-demographic characteristics.

<p>Prevalence of anti-HEV IgM among pregnant women according to socio-demographic characteristics.</p

Prevalence of anti-HEV total antibodies (IgG+IgM) among pregnant women according to socio-demographic characteristics.

<p>Prevalence of anti-HEV total antibodies (IgG+IgM) among pregnant women according to socio-demographic characteristics.</p

Sequences of primers for detection of hepatitis E virus.

<p>Sequences of primers for detection of hepatitis E virus.</p

Yearly seroprevalence of HCV infection among blood donors according to socio-demographic characteristics.

<p>Yearly seroprevalence of HCV infection among blood donors according to socio-demographic characteristics.</p

Trends of HBV, HCV and HIV infections among blood donors in south of Iran, 2004–2014.

<p>Trends of HBV, HCV and HIV infections among blood donors in south of Iran, 2004–2014.</p

Socio-demographic characteristics of blood donors in south of Iran, 2004–2014.

<p>Socio-demographic characteristics of blood donors in south of Iran, 2004–2014.</p