Anthelmintic activity of extracts of coriandrum sativum linn. In indian earthworm

Coriandrum sativum Linn. (CSL) is popularly known as coriander in India belongs to family Apiaceae. The objective of the present work was to evaluate the in-vitro anthelmintic potency of the ethanolic extract and carbon tetrachloride extract of Coriandrum sativum Linn. plant using Indian earthworms (Pheretima posthumad). The various concentrations (50, 100, and 150 mg/ml) of the ethanolic extract and carbon tetrachloride extract were tested in-vitro for anthelmintic potency by determination of time of paralysis and time of death of worm. Piperazine citrate (15mg/ml) used as standard. The result of present study indicates that the Coriandrum sativum Linn. potentiate to paralyze earthworm and also caused its death after some time. The shortest time of paralysis was observed at higher dose (150 mg/ml) of both ethanolic extract and carbon tetrachloride were found to 28 min and 45 min respectively. The results of the study are comparable to standard Piperazine citrate. The result showed that ethanolic extract of Coriandrum sativum Linn. took less time to cause paralysis of the earthworm than that of carbon tetrachloride extract Coriandrum sativum Linn.. Thus the present study demonstrate that the Coriandrum sativum Linn. as an anthelmintic has been confirm as the ethanolic and carbon tetrachloride extracts of whole plant displayed activity against the earthworm used in study. Key word: CSL, Paralysis, death of earthworm

Essence of Ayurveda: The traditional medical science

333-345As the health care professions look seriously at complementary and alternative modalities of medicine, a growing interest in traditional Indian medicine is emerging simultaneously. As with any popular development, aspects of the Indian medical system and its cures have sometimes been appropriated by individuals not wholly familiar with the basics of Ayurveda or the Science of Longevity. Over the past decade, however, a group of dedicated scholars has undertaken serious study of this ancient healing tradition. It is appropriate to present the fundamental principles and practices of traditional Ayurveda, as they may be understood from classical Sanskrit sources and traditional Indian practitioners. Traditional Ayurveda is a sophisticated system of medicine that has been practiced in India for over 2,500 years. Like other forms of alternative and complementary medicine, it focuses on the whole organism and its relation to the external world, in order to reestablish and maintain the harmonious balance that exists within the body and between the body and its environment. Only a glimpse of this ancient form of medicine has been offered; there is much to be learned from a deeper exploration of Ayurveda. Here the authors stress the various aspects of traditional practice of an ancient Indian medical science i.e. Ayurveda

Medicinal plants used by the tribals for hair disorders in Melghat forest of Amravati district, Maharashtra

351-355Products from natural sources are an integral part of human health care system because there are major concern about synthetic drugs owing to their side effects and toxicity. The present study is an attempt to investigate the medicinal plants used for hair disorders by tribal women community based in the Melghat forest of Amravati district. Twenty four plant species belonging to 22 families of ethnomedicinal interest are recorded after survey and critical screening

Simultaneous spectrophotometric estimation of nitazoxanide and ofloxacin in tablets

Two simple, accurate and precise spectrophotometric methods have been developed for simultaneous determination of nitazoxanide and ofloxacin in tablets. Method I is Q-absorbance ratio method which involves Q-absorbance at isobestic point (306.25 nm) and max (347.5 nm) of nitazoxanide, while method II is two wavelength method, where 244.6 nm and 273.0 nm were selected as 1 and 2 for determination of nitazoxanide and 294.3 nm and 388.1 nm were selected as 3 and 4 for determination of ofloxacin. Both drugs obeyed the Beer′s law in the concentration range 2-30 μg/ml,correlation coefficient (r 2 <1). Both methods were validated statistically and recovery studies were carried out to confirm the accuracy. Commercial tablet formulation was successfully analyzed using the developed methods

Effect of fluoxetine on an experimental model of diabetes-induced neuropathic pain perception in the rat

The aim of the present study was to study the effect of chronic treatment (9 weeks) of fluoxetine (20 mg/kg p.o.) a selective serotonin reuptake inhibitor on blood glucose level and in prevention of diabetic neuropathic pain perception. Evaluation of diabetic neuropathy was performed after 9 weeks of single injection of streptozotocin (70 mg/kg i.v.) in rats. Blood glucose level, glycated haemoglobin, grip strength, pain sensitivity and threshold in diabetic rats were measured at the end of 9 weeks. The results of the present study indicate that the 9 weeks treatment of fluoxetine demonstrates hypoglycemic effect; it marked decreases the blood glucose level in diabetic treated animals. There was also decrease in the grip strength in diabetic rat indicates to induction of neuropathy or nerve damage. Fluoxetine increase the grip strength of diabetic rats. There was also found loss of pain perception in diabetes rats which measured using hot plate and tail flick methods. Fluoxetine increases the licking time and withdrawal latency in hot plate and tail flick test respectively indicates the presence of pain perception and prevention of nerve damage demonstrates its protective effect in diabetic neuropathy. Our study concludes the chronic treatment of fluoxetine significantly decreases the glycemic level as well as it protected from the development of diabetic neuropathy

Development and Evaluation of Oral Controlled Release Chlorpheniramine-Ion Exchange Resinate Suspension

An oral controlled release suspension of chlorpheniramine maleate was prepared using ion-exchange resin technology. A strong cation exchange resin Indion 244 was utilized for the sorption of the drug and the drug resinates was evaluated for various physical and chemical parameters. The drug-resinate complex was microencapsulated with a polymer Eudragit RS 100 to further retard the release characteristics. Both the drug-resinate complex and microencapsulated drug resinate were suspended in a palatable aqueous suspension base and were evaluated for controlled release characteristic. Stability study indicated that elevated temperature did not alter the sustained release nature of the dosage form indicating that polymer membrane surrounding the core material remained intact throughout the storage period