Emergent Supersymmetry in Warped Backgrounds

We show that quantum mechanical supersymmetries are emerged in Kaluza-Klein spectrum of linearized gravity in several warped backgrounds as a consequence of higher-dimensional general coordinate invariance. These emergent supersymmetries play an essential role for the spectral structure of braneworld gravity. We show that for the case of braneworld models with two codimension-1 branes the spectral pattern is completely determined only through the supersymmetries

Participatory Planning: Gaining a Voice in the Digital Divide

Technology is advancing at an astonishing rate and the tools to collect and analyze large amounts of data are now becoming readily available. Urban planners have begun to utilize these tools including online surveys for example. The relative newness of such tools begs for best practices for these new methods. These tools have also changed the frame around the conversation of inclusion and democratic planning in this modern era. Two planning methodologies from prominent documents are compared and contrasted in this research study. The Second Regional Plan by the Regional Plan Association in 1967 and the PlaNYC 2030’s policy recommendations by the New York City Mayor’s Office Long-term Planning and Sustainability (OLTPS) in 2010 are the case studies selected. Lastly, the public has been given more access than previously offered by supporting institutions such as the New York Public Library System in New York City and the support has proven to be an effective outlet for bridging the digital divide. Libraries are important places where residents can gain access to the global information society, learn, seek entertainment, and connect with others using the Internet. Urban planning can greatly benefit from understanding Internet usage to give all residents an equal voice in the planning process to meet the goals of true democracy

Gauge-Fixing and Residual Symmetries in Gauge/Gravity Theories with Extra Dimensions

We study compactified pure gauge/gravitational theories with gauge-fixing terms and show that these theories possess quantum mechanical SUSY-like symmetries between unphysical degrees of freedom. These residual symmetries are global symmetries and generated by quantum mechanical N=2 supercharges. Also, we establish new one-parameter family of gauge choices for higher-dimensional gravity, and calculate as a check of its validity one graviton exchange amplitude in the lowest tree-level approximation. We confirm that the result is indeed $\xi$-independent and the cancellation of the $\xi$-dependence is ensured by the residual symmetries. We also give a simple interpretation of the vDVZ-discontinuity, which arises in the lowest tree-level approximation, from the supersymmetric point of view.Comment: REVTeX4, 17 pages, 1 figur

Safer Use of Metformin for Chronic Kidney Disease (CKD) and/or Diabetic Kidney Disease (DKD) with Beneficial Efficacy

Diabetes has been a prevalent disease worldwide, and metformin has been used widely as an oral hypoglycemic agent (OHA) for type 2 diabetes mellitus (T2DM). Its benefits include low cost, weight neutrality, general effect and positive efficacy for cardiovascular system. American Diabetes Association (ADA) has proposed diabetic guidelines-2020 and evaluated metformin as predominant agent. They include i) the preferred initial pharmacologic agent for T2DM, ii) once starting of metformin, it should be continued as long as tolerated without contraindication. Furthermore, recent studies showed safer effect for impaired renal function. We cannot exclude such results and will contribute the prevention of atherosclerotic cardiovascular disease (ASCVD)

Satisfactory Rapid Response to Xultophy Associated with Meal Tolerance Test (MTT) by Carbohydrate Loading

The case is a 69-year-old male patient with Type 2 Diabetes Mellitus （T2DM） for 21 years. His diabetic control was not so satisfactory, and his HbA1c value increased in spring 2021. Then, he started Xultophy (IDegLira), which includes a fixed ratio of two agents of basal degludec and liraglutide. Just after providing Xultophy, the daily profile of blood glucose decreased from 179-400 mg/dL to 112-171 mg/dL, with remarkable clinical efficacy. He usually takes 80g of carbohydrates in breakfast, and the meal tolerance test (MTT) was challenged. As carbohydrate loading was given 100-75-50-0%, postprandial hyperglycemia at 60-min showed 277-219-159-133 mg/dL, respectively

Effective Single Twymeeg Administration for Elderly Patient with Type 2 Diabetes (T2D), Arthralgia and Depression as Common Medical Problems

Background: Imeglimin (Twymeeg) has been effective for patients with type 2 diabetes (T2D). Case Presentation: The patient is an 82-year-old female with T2D, arthralgia, and depression. Results: She was given duloxetine hydrochloride (Cymbalta) and Twymeeg, leading to improved symptoms of low back pain (LBP), knee osteoarthritis, osteoporosis, depression, and possible mild cognitive impairment (MCI). HbA1c decreased from 8.8% to 7.1% for 4 months with a single administration of Twymeeg 2000mg/day. Discussion: In recent clinical practice, elderly cases often tend to have simultaneously these problems, which are medical and social crucial problems. Twymeeg and Cymbalta may be indispensable agents for future practice

Beneficial Xultophy Treatment from Medical and Social Points of View

The case is a 65-year-old male who has been treated for Type 2 diabetes mellitus (T2DM) for 26 years. He has no previous history of cerebral vascular accident (CVA) or coronary heart disease (CHD). He has been treated on insulin therapy, and recently his glucose variability became worse due to the irregular lifestyle. Then, diabetic treatment was changed to Xultophy, which consists of insulin degludec and liraglutide. Providing 16 units of Xultophy brought him a satisfactory daily profile of blood glucose, which seemed to be lower doses compared with the ordinary standard amount. Treatment of Xultophy seems to be effective and some discussion would be described from several points of view

Assessment of traffic accidents in Japan during the COVID-19 pandemic vs. previous years: a preliminary report

Beginning in April 2020, social distancing measures were implemented to mitigate the COVID-19 pandemic in Japan. We assessed whether traffic accident rates had decreased from April 2020 to December 2021 as compared with previous years. The analysis included 2,934,477 traffic accidents, and the trend of decreasing rates of traffic accidents in recent years and seasonal fluctuations in traffic accidents were considered. The yearly change in the traffic accident rate between 2015 and 2019 was estimated, and the traffic accident rate in 2020 and 2021 was predicted. This was followed by the comparison of observed vs. predicted traffic accident rate. In 2020, the observed vs. expected rates of traffic accidents were lower in April to December 2020, and the rate of traffic accidents in Japan was 30–40% lower in April–May 2020 than would be expected based on trends from previous years. In 2021, rates of traffic accidents remained lower than expected between January and November, but the magnitude of decrease was not as pronounced. These findings could be explained by social distancing policies, including the declaration of the state of emergency, and the relaxation of public health and social measures over time