136 research outputs found
Choriocarcinoma coexisting with epithelioid trophoblastic tumor of the uterine horn
• We report a choriocarcinoma coexisting with an epithelioid trophoblastic tumor. • Chemotherapy with methotrexate, etoposide, and actinomycin-D was efficacious. • Choriocarcinoma with epithelioid trophoblastic tumor may benefit from chemotherapy
High abundance ratio of CO to CO toward photon-dominated regions in the Orion-A giant molecular cloud
Aims. We derive physical properties such as the optical depths and the column
densities of CO and CO to investigate the relationship between
the far ultraviolet (FUV) radiation and the abundance ratios between CO
and CO.
Method. We have carried out wide-field (0.4 deg) observations with an
angular resolution of 25.8 arcsec ( 0.05 pc) in CO (=1--0) and
CO (=1--0) toward the Orion-A giant molecular cloud using the
Nobeyama 45 m telescope in the on-the-fly mode.
Results. Overall distributions and velocity structures of the CO and
CO emissions are similar to those of the CO (=1--0) emission.
The optical depths of the CO and C18O emission lines are estimated to be
0.05 1.54 and 0.01
0.18, respectively. The column densities of the CO and CO
emission lines are estimated to be 0.2 10
3.7 10 cm and 0.4 10 3.5 10 cm, respectively. The abundance
ratios between CO and CO, /,
are found to be 5.7 - 33.0. The mean value of / in the nearly edge-on photon-dominated regions is found to be 16.47
0.10, which is a third larger than that the solar system value of 5.5.
The mean value of / in the other regions is
found to be 12.29 0.02. The difference of the abundance ratio is most
likely due to the selective FUV photodissociation of CO.Comment: 11 pages, 9 figures, Accepted to A&
Integrin α5 regulates motility of human monocyte-derived Langerhans cells during immune response
Guo Z., Murakami M., Saito K., et al. Integrin α5 regulates motility of human monocyte-derived Langerhans cells during immune response. Experimental Dermatology 33, e15021 (2024); https://doi.org/10.1111/exd.15021.Langerhans cells (LCs) are mainly present in the epidermis and mucosa, and have important roles during skin infection. Migration of LCs to lymph nodes is essential for antigen presentation. However, due to the difficulties in isolating and culturing human LCs, it is not fully understood how LCs move and interact with the extracellular matrix (ECM) through their adhesion molecules such as integrin, during the immune responses. In this study, we aimed to investigate LC motility, cell shape and the role of integrin under inflammatory conditions using monocyte-derived Langerhans cells (moLCs) as a model. As a result, lipopolysaccharide (LPS) stimulation increased adhesion on fibronectin coated substrate and integrin α5 expression in moLCs. Time-lapse imaging of moLCs revealed that stimulation with LPS elongated cell shape, whilst decreasing their motility. Additionally, this decrease in motility was not observed when pre-treated with a neutralising antibody targeting integrin α5. Together, our data suggested that activation of LCs decreases their motility by promoting integrin α5 expression to enhance their affinity to the fibronectin, which may contribute to their migration during inflammation
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