136 research outputs found

    Choriocarcinoma coexisting with epithelioid trophoblastic tumor of the uterine horn

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    • We report a choriocarcinoma coexisting with an epithelioid trophoblastic tumor. • Chemotherapy with methotrexate, etoposide, and actinomycin-D was efficacious. • Choriocarcinoma with epithelioid trophoblastic tumor may benefit from chemotherapy

    High abundance ratio of 13^{13}CO to C18^{18}O toward photon-dominated regions in the Orion-A giant molecular cloud

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    Aims. We derive physical properties such as the optical depths and the column densities of 13^{13}CO and C18^{18}O to investigate the relationship between the far ultraviolet (FUV) radiation and the abundance ratios between 13^{13}CO and C18^{18}O. Method. We have carried out wide-field (0.4 deg2^2) observations with an angular resolution of 25.8 arcsec (∼\sim 0.05 pc) in 13^{13}CO (JJ=1--0) and C18^{18}O (JJ=1--0) toward the Orion-A giant molecular cloud using the Nobeyama 45 m telescope in the on-the-fly mode. Results. Overall distributions and velocity structures of the 13^{13}CO and C18^{18}O emissions are similar to those of the 12^{12}CO (JJ=1--0) emission. The optical depths of the 13^{13}CO and C18O emission lines are estimated to be 0.05 << τ13CO\tau_{\rm ^{13}CO} << 1.54 and 0.01 << τC18O\tau_{\rm C^{18}O} << 0.18, respectively. The column densities of the 13^{13}CO and C18^{18}O emission lines are estimated to be 0.2 ×\times 1016^{16} << N13CON_{\rm ^{13}CO} << 3.7 ×\times 1017^{17} cm−2^{-2} and 0.4 ×\times 1015^{15} << NC18ON_{\rm C^{18}O} << 3.5 ×\times 1016^{16} cm−2^{-2}, respectively. The abundance ratios between 13^{13}CO and C18^{18}O, X13COX_{\rm ^{13}CO}/XC18OX_{\rm C^{18}O}, are found to be 5.7 - 33.0. The mean value of X13COX_{\rm ^{13}CO}/XC18OX_{\rm C^{18}O} in the nearly edge-on photon-dominated regions is found to be 16.47 ±\pm 0.10, which is a third larger than that the solar system value of 5.5. The mean value of X13COX_{\rm ^{13}CO}/XC18OX_{\rm C^{18}O} in the other regions is found to be 12.29 ±\pm 0.02. The difference of the abundance ratio is most likely due to the selective FUV photodissociation of C18^{18}O.Comment: 11 pages, 9 figures, Accepted to A&

    Integrin α5 regulates motility of human monocyte-derived Langerhans cells during immune response

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    Guo Z., Murakami M., Saito K., et al. Integrin α5 regulates motility of human monocyte-derived Langerhans cells during immune response. Experimental Dermatology 33, e15021 (2024); https://doi.org/10.1111/exd.15021.Langerhans cells (LCs) are mainly present in the epidermis and mucosa, and have important roles during skin infection. Migration of LCs to lymph nodes is essential for antigen presentation. However, due to the difficulties in isolating and culturing human LCs, it is not fully understood how LCs move and interact with the extracellular matrix (ECM) through their adhesion molecules such as integrin, during the immune responses. In this study, we aimed to investigate LC motility, cell shape and the role of integrin under inflammatory conditions using monocyte-derived Langerhans cells (moLCs) as a model. As a result, lipopolysaccharide (LPS) stimulation increased adhesion on fibronectin coated substrate and integrin α5 expression in moLCs. Time-lapse imaging of moLCs revealed that stimulation with LPS elongated cell shape, whilst decreasing their motility. Additionally, this decrease in motility was not observed when pre-treated with a neutralising antibody targeting integrin α5. Together, our data suggested that activation of LCs decreases their motility by promoting integrin α5 expression to enhance their affinity to the fibronectin, which may contribute to their migration during inflammation
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