Retrieve-and-Read: Multi-task Learning of Information Retrieval and Reading Comprehension

This study considers the task of machine reading at scale (MRS) wherein, given a question, a system first performs the information retrieval (IR) task of finding relevant passages in a knowledge source and then carries out the reading comprehension (RC) task of extracting an answer span from the passages. Previous MRS studies, in which the IR component was trained without considering answer spans, struggled to accurately find a small number of relevant passages from a large set of passages. In this paper, we propose a simple and effective approach that incorporates the IR and RC tasks by using supervised multi-task learning in order that the IR component can be trained by considering answer spans. Experimental results on the standard benchmark, answering SQuAD questions using the full Wikipedia as the knowledge source, showed that our model achieved state-of-the-art performance. Moreover, we thoroughly evaluated the individual contributions of our model components with our new Japanese dataset and SQuAD. The results showed significant improvements in the IR task and provided a new perspective on IR for RC: it is effective to teach which part of the passage answers the question rather than to give only a relevance score to the whole passage.Comment: 10 pages, 6 figure. Accepted as a full paper at CIKM 201

Molecular cloning of a cDNA encoding human ribosomal protein L39

A cDNA clone encoding a human ribosomal protein L39 (hRPL39) was isolated through a random cDNA sequencing approach to a cDNA library constructed from a human colon carcinoma cell line of COLO 205. Although levels of hRPL39 mRNA were different in several cell lines including carcinoma cell lines from different tissues, they were shown not to be cell cycle-dependent in a human fibroblast cell line of TIG-1

STUDI VARIASI MUSIMAN KEMUNCULAN PLASMA BUBBLE MENGGUNAKAN AIRGLOW IMAGER DAN GPS SINTILASI DI ATAS KOTOTABANG [STUDY ON SEASONAL VARIATION OF PLASMA BUBBLE OCCURRENCES OBSERVED BY GPS SCINTILLATION AND AIRGLOW MEASUREMENTS OVER KOTOTABANG]

Dengan meningkatnya ketergantungan pada sistem penentuan posisi berbasis satelit, navigasi dan waktu pada GNSS, prediksi kejadian gelembung plasma menjadi lebih dibutuhkan. Penelitian ini bertujuan untuk mengetahui karakter dampak iregularitas ionosfer yang terkait dengan kejadian gelembung plasma dan sintilasi pada aplikasi GNSS selama aktivitas matahari menurun. Untuk mendapatkan informasi variasi musiman iregularitas ionosfer yang terkait dengan gelembung plasma, kami menggunakan All-sky Airglow Imager (ASI) yang dipasang di Kototabang (0.2ºLS, 100.3ºBT, -10,4º lintang magnetik) Indonesia, untuk mendeteksi penipisan kepadatan plasma skala besar dalam bentuk citra dua dimensi, indeks amplitudo sintilasi (S4) yang diperoleh dari tiga single-frequency GPS receiver yang dipasang di lokasi yang sama dan kejadian badai magnetik (indeks Dst) yang diperoleh dari World Data Center for Geomagnetism, Kyoto. Kami menganalisis kejadian gelembung plasma pada citra ASI dari tahun 2003-2009 dan menemukan bahwa tingkat kejadian tertinggi pada bulan Mei-Juli yang berbeda dari variasi musiman kejadian gelembung plasma yang umumnya diketahui selama ini. Tingkat kejadian yang tinggi pada Mei-Juli bukan disebabkan oleh badai magnetik, karena statistik menunjukkan tidak ada perubahan yang signifikan setelah peristiwa gelembung plasma yang mungkin disebabkan oleh badai magnetik dieliminasi. Kami juga mempelajari hubungan spasial antara sintilasi ionosfer dan struktur gelembung plasma skala besar yang terlihat pada citra ASI. Kami menemukan beberapa peristiwa dimana IPPs dari satelit GPS berada di dalam struktur gelembung plasma skala besar pada citra ASI, tetapi tidak teramati adanya sintilasi.Kata Kunci: Gelembung plasma, Sintilasi, Badai magnetik, GNSS

Transition region of TEC enhancement phenomena during geomagnetically disturbed periods at mid-latitudes

Large-scale TEC perturbations/enhancements observed during the day sectors of major storm periods, 12-13 February 2000, 23 September 1999, 29 October 2003, and 21 November 2003, were studied using a high resolution GPS network over Japan. TEC enhancements described in the present study have large magnitudes (≥25×10<sup>16</sup> electrons/m<sup>2</sup>) compared to the quiet-time values and long periods (≥120 min). The sequential manner of development and the propagation of these perturbations show that they are initiated at the northern region and propagate towards the southern region of Japan, with velocities >350 m/s. On 12 February 2000, remarkably high values of TEC and background content are observed at the southern region, compared to the north, because of the poleward expansion of the equatorial anomaly crest, which is characterized by strong latitudinal gradients near 35° N (26° N geomagnetically). When the TEC enhancements, initiating at the north, propagate through the region 39-34° N (30-25° N geomagnetically), they undergo transitions characterized by a severe decrease in amplitude of TEC enhancements. This may be due to their interaction with the higher background content of the expanded anomaly crest. However, at the low-latitude region, below 34° N, an increase in TEC is manifested as an enhanced ionization pattern (EIP). This could be due to the prompt penetration of the eastward electric field, which is evident from high values of the southward Interplanetary Magnetic Field component (IMF <i>B<sub>z</sub></i>) and AE index. The TEC perturbations observed on the other storm days also exhibit similar transitions, characterized by a decreasing magnitude of the perturbation component, at the region around 39-34° N. In addition to this, on the other storm days, at the low-latitude region, below 34° N, an increase in TEC (EIP feature) also indicates the repeatability of the above scenario. It is found that, the latitude and time at which the decrease in magnitude of the perturbation component/amplitude of the TEC enhancement are matching with the latitude and time of the appearance of the high background content. In the present study, on 12 February 2000, the F-layer height increases at Wakkanai and Kokubunji, by exhibiting a typical dispersion feature of LSTID, or passage of an equatorward surge, which is matching with the time of occurrence of the propagating TEC perturbation component. Similarly, on 29 October 2003, the increase in F-layer heights by more than 150km at Wakkanai and 90 km at Kokubunji around 18:00 JST, indicates the role of the equatorward neutral wind. On that day, TEC perturbation observed at the northern region, after 18:30 JST, which propagates towards south, could be caused mainly by the equatorward neutral wind, leading to an F-layer height increase. These observations imply the role of the equatorward neutral wind, which increases the F-layer height, by lifting the ionization to the regions of lower loss during daytime, when production is still taking place, which, in turn, increases the TEC values. <P style="line-height: 20px;"> Large-scale traveling ionospheric disturbances (LSTIDs) are considered as ionospheric manifestations of the passage of Atmospheric Gravity Waves (AGWs) that are generated at the high latitude by energy input from the magnetosphere to the low-latitude ionosphere. This study shows that large-scale TEC perturbations observed here are produced at the northern region due to the combined effects of the equatorward neutral wind, the subsequent F-layer height increase, and LSTIDs. When these perturbation components propagate through the region, 39-34° N, they undergo transitions characterised by a decrease in magnitude. Also, at the low-latitude region, below 34° N, an increase in the TEC exhibits EIP feature, due to the prompt penetration of the eastward electric field

3-years Occurrence Variability of Concentric Gravity Waves in the Mesopause Observed by IMAP/VISI

第6回極域科学シンポジウム分野横断型セッション：[IM] 横断　中層大気・熱圏11月17日（火）　統計数理研究所 セミナー室2（D304

New Short Term Prediction Method for Chemical Carcinogenicity by Hepatic Transcript Profiling Following 28-Day Toxicity Tests in Rats

We have previously shown the hepatic gene expression profiles of carcinogens in 28-day toxicity tests were clustered into three major groups (Group-1 to 3). Here, we developed a new prediction method for Group-1 carcinogens which consist mainly of genotoxic rat hepatocarcinogens. The prediction formula was generated by a support vector machine using 5 selected genes as the predictive genes and predictive score was introduced to judge carcinogenicity. It correctly predicted the carcinogenicity of all 17 Group-1 chemicals and 22 of 24 non-carcinogens regardless of genotoxicity. In the dose-response study, the prediction score was altered from negative to positive as the dose increased, indicating that the characteristic gene expression profile emerged over a range of carcinogen-specific doses. We conclude that the prediction formula can quantitatively predict the carcinogenicity of Group-1 carcinogens. The same method may be applied to other groups of carcinogens to build a total system for prediction of carcinogenicity

Discrimination of Carcinogens by Hepatic Transcript Profiling in Rats Following 28-day Administration

This study aimed at discriminating carcinogens on the basis of hepatic transcript profiling in the rats administrated with a variety of carcinogens and non-carcinogens. We conducted 28-day toxicity tests in male F344 rats with 47 carcinogens and 26 non-carcinogens, and then investigated periodically the hepatic gene expression profiles using custom microarrays. By hierarchical cluster analysis based on significantly altered genes, carcinogens were clustered into three major groups (Group 1 to 3). The formation of these groups was not affected by the gene sets used as well as the administration period, indicating that the grouping of carcinogens was universal independent of the conditions of both statistical analysis and toxicity testing. Seventeen carcinogens belonging to Group 1 were composed of mainly rat hepatocarcinogens, most of them being mutagenic ones. Group 2 was formed by three subgroups, which were composed of 23 carcinogens exhibiting distinct properties in terms of genotoxicity and target tissues, namely nonmutagenic hepatocarcinogens, and mutagenic and nonmutagenic carcinogens both of which are targeted to other tissues. Group 3 contained 6 carcinogens including 4 estrogenic substances, implying the group of estrogenic carcinogens. Gene network analyses revealed that the significantly altered genes in Group 1 included Bax, Tnfrsf6, Btg2, Mgmt and Abcb1b, suggesting that p53-mediated signaling pathway involved in early pathologic alterations associated with preceding mutagenic carcinogenesis. Thus, the common transcriptional signatures for each group might reflect the early molecular events of carcinogenesis and hence would enable us to identify the biomarker genes, and then to develop a new assay for carcinogenesis prediction