Postinfectious Glomerulonephritis with Crescents in an Elderly Diabetic Patient after Acute Gastroenteritis: Case Report

Postinfectious glomerulonephritis (PIGN) is primarily a disease of childhood. It occurs after upper respiratory tract infection or skin infections. Streptococcus is the most common causative agent, but in the elderly, staphylococcus is the main culprit. In adults, PIGN is more common in immunocompromised patients, particularly diabetics and alcoholics. Here, we report the case of an elderly diabetic male who presented with severe acute kidney injury with active urinary sediment after acute gastroenteritis. Additional analyses revealed a very low serum C3 level and a normal serum C4 level. Renal biopsy showed diffuse proliferative glomerulonephritis with crescents. Direct immunofluorescence showed mesangial and capillary wall staining for C3 and IgG (2+, mesangial and segmental capillary wall, granular). Renal electron microscopy showed subepithelial hump-like electron-dense deposits. The role of steroid in the treatment of PIGN is controversial and there is no standard protocol, but our patient responded very well to steroid as he did not require hemodialysis after 2 weeks of initiation of steroid therapy. We should be aware of an atypical presentation of PIGN in elderly to ensure correct diagnosis

Clinical profile and drug resistance patterns of typhoid fever in children: A prospective hospital-based study

Background: Salmonella typhi and Salmonella paratyphi are important causes of bacteremia in children, especially those from the developing world. The present study is undertaken to study the pattern of antimicrobial resistance of S. typhi in culture positive cases of enteric fever. Materials and Methods: This prospective non-randomized study was conducted in the Department of Pharmacology, J. N. Medical College, AMU, Aligarh, in association with the Department of Paediatrics and Department of Microbiology, J. N. Medical College, on pediatric patients attending the Outpatient/Inpatient Department of Paediatrics, over a period of 1 year and 11 months from September 2005 to August 2006. For all patients with suspected enteric fever, the following investigations were sent for complete hemogram, blood culture, and sensitivity test and Widal test. Results: About 114 randomly selected children having clinical features strongly suggestive of uncomplicated enteric fever with either culture positive or serology positive or both were entered in the study. Fever was the most common clinical presentation and was present in 94.7%. Only 25% of patients attended the hospital within the 1st week of illness, while maximum (54.6%) patients came to the hospital in the 2nd week of illness. Hepatomegaly was more common (43.8%) as compared to splenomegaly (27.1%). The characteristic rose spots of enteric fever were a rare finding in children. Conclusion: Burden of typhoid fever in endemic areas of India underscores the importance of evidence on disease burden in making policy decisions about interventions to control this disease. Our antimicrobial susceptibility data suggest that quinolones and third-generation cefalosporins should be used as first-line antimicrobials in enteric fever. A careful consideration should be given before deciding the antibiotic for treatment to prevent the emergence of antibiotic resistance. Key words: ,,,&nbsp

Rifampicin-Associated Secondary Minimal Change Disease Presenting with Nephrotic Syndrome in a Pulmonary Tuberculosis Patient

Various extraglomerular disease processes have been associated with drug-induced secondary minimal change disease (MCD). In a majority of cases, preferably, a hypersensitivity reaction appears to be involved, and in some cases, there is direct toxic effect over glomerular capillaries. There are several reports to demonstrate that rifampicin has been associated with various nephrotoxic adverse effects, but rifampicin-induced secondary minimal change disease (MCD) is very rare. Here, we report the case of a young adult male who presented with nephrotic proteinuria with bland urine sediment after one month of initiation of rifampicin treatment for pulmonary tuberculosis. The patient had no proteinuria before the start of antituberculosis treatment. Renal biopsy showed nonproliferative glomerulopathy and immunofluorescence did not show significant glomerular immune deposits. Electron microscopy showed diffuse effacement of visceral epithelial cell foot processes and did not show any presence of glomerular immune complexes and thickening of glomerular basement membrane, promoting the diagnosis of minimal change nephrotic syndrome. The patient got complete remission after discontinuation of rifampicin

Comparative study of pattern of infections in adult patients presenting as Acute Japanese Encephalitis and Acute Non Japanese Viral Encephalitis in tertiary care centre in Eastern Uttar Pradesh

Introduction : Acute encephalitis syndrome (AES) caused by Japanese encephalitis (JE) virus is a major health problem in Eastern Uttar Pradesh in India since 1978. In last 10 years a change in pattern of AES has been noticed, with two distinct patterns. One group has AES with extrapyramidal involvement and higher JE virus positivity, while the other has concomitant systemic involvement, mimicking enterovirus infection with low JE virus positivity. Aim& objectives :To compare the pattern of infections in adult patients presenting as Acute JE and Acute Non JE in a tertiary care centre in Eastern Uttar Pradesh.Methods : Fifty eight patients of JE were compared with the 115 patients with Non JE viral encephalitis for demography, clinical features, investigations, complications and outcome. It was a prospective study with one month follow up. Results & Conclusion : Cases of JE came mostly from August to October, while cases of Non JE came throughout the year. Abdominal pain, loose stools, swelling of body and breathlessness were more common in Non JE patients. Hepatomegaly, icterus, ascitis and raised JVP were more common in Non JE patients. Non JE cases have multisystem involvement like renal, hepatic and cardiac. Cerebellar signs, extrapyramidal signs, brisk DTR, hypertonia and hemiparesis were predominant in JE.Full recovery was achieved in 68.96% in JE and 74.78% in Non JE. Partial recovery with sequelae was seen in 13.79% in JE and 11.30% in Non JE. The case fatality rate was 13.79% in JE and 10.43% in Non JE

Book of Abstracts of the 2nd International Conference on Applied Mathematics and Computational Sciences (ICAMCS-2022)

It is a great privilege for us to present the abstract book of ICAMCS-2022 to the authors and the delegates of the event. We hope that you will find it useful, valuable, aspiring, and inspiring. This book is a record of abstracts of the keynote talks, invited talks, and papers presented by the participants, which indicates the progress and state of development in research at the time of writing the research article. It is an invaluable asset to all researchers. The book provides a permanent record of this asset. Conference Title: 2nd International Conference on Applied Mathematics and Computational SciencesConference Acronym: ICAMCS-2022Conference Date: 12-14 October 2022Conference Organizers: DIT University, Dehradun, IndiaConference Mode: Online (Virtual