A Multi-Criteria Neutrosophic Group Decision Making Method Based TOPSIS for Supplier Selection

The process of multi-criteria group decision making (MCGDM) is of determining the best choice among all of the probable alternatives. The problem of supplier selection on which decision maker has usually vague and imprecise knowledge is a typical example ofmulti criteria group decision-making problem. The conventional crisp techniques has notmuch effective for solvingMCDMproblems because of imprecise or fuzziness nature of the linguistic assessments. To find the exact values for MCGDM problems is both difficult and impossible in more cases in real world. So, it is more reasonable to consider the values of alternatives according to the criteria as single valued neutrosophic sets (SVNS). This paper deal with the technique for order preference by similarity to ideal solution (TOPSIS) approach and extend the TOPSIS method to MCGDM problem with single valued neutrosophic information. The value of each alternative and the weight of each criterion are characterized by single valued neutrosophic numbers. Here, the importance of criteria and alternatives is identified by aggregating individual opinions of decision makers (DMs) via single valued neutrosophic weighted averaging (SVNWA) operator. The proposed method is, easy use, precise and practical for solving MCGDM problem with single valued neutrosophic data. Finally, to show the applicability of the developed method, a numerical experiment for supplier choice is given as an application of single valued neutrosophic TOPSIS method at end of this paper

Streptomyces scabichelini sp. nov., isolated from soil

A novel actinomycete, designated strain HC44(T), was isolated from a soil sample collected from Hacibektas, Turkey, and characterized using a polyphasic approach. The strain had morphological characteristics and chemotaxonomic properties identical to those of members of the genus Streptomyces. Phylogenetic analyses based on 16S rRNA gene sequence comparisons revealed that HC44(T) clustered with members of the genus Streptomyces and the highest 16S rRNA gene sequence similarity values were obtained with Streptomyces vastus NBRC 13094(T) (97.6%) and Streptomyces kalpinensis TRM 46509(T) (96.9%). Multi-locus sequence analysis (MLSA) based on five housekeeping genes (atpD, gyrB, recA, rpoB and trpB) showed that the MLSA evolutionary distance value was 0.043 between strain HC44(T) and S. vastus NBRC 13094(T). Whole-cell hydrolysates contained LL-diaminopimelic acid, glucose, mannose and ribose. The predominant menaquinones were MK-9(H-6) and MK-9(H-8). The major polar lipids were diphosphatidylglycerol, phosphatidylethanolamine, phosphatidylinositol and phosphatidylinositol mannoside. The DNA G+C content of the draft genome sequence, consisting of 11.2 Mbp, was 69.8 mol%. On the basis of polyphasic taxonomic evidence, strain HC44(T) represents a novel species of the genus Streptomyces, for which the name Streptomyces scabichelini sp. nov. is proposed. The type strain is HC44(T) (=DSM 106874(T)=KCTC 39872(T))

Mortality-Related Risk Factors in Geriatric Patients with Hip Fracture

Background: Mortality rates after hip fractures increase by up to 30% with age. This study in-vestigated the contribution of various parameters to prognosis and mortality. Methods: Our study prospectively examined patients with hip fracture aged 65 years and over who applied to the Atatürk University Medical Faculty Hospital Orthopedics Service in 2020–2021. Results: The 120 patients included in the study had a mean age of 79.71±7.27 years, and 51.7% were female. Twenty patients (16.7%) died within the first 30 days after a hip fracture. They had a significantly lower median Lawton–Brody instrumental activities of daily living (IADL) scale score (p=0.045) and a higher rate of malnutrition according to the Mini Nutritional Assessment (MNA) score (p=0.016). Additionally, these patients with 30-day mortality had a significantly lower rate of surgical treatment (p=0.027) and a longer time from injury to surgery (p=0.014). The time to surgery was a significant independent risk factor for 30-day mortality, with each 1-hour delay in-creasing the odds of mortality by 1.066 (odds ratio [OR]=1.066; 95% confidence interval [CI], 1.001–1.013; p=0.013). In addition, the presence of malnutrition was another independent risk factor that increased the odds of mortality by 4.166 times (OR=4.166; 95% CI, 1.285–13.427; p=0.017). Conclusion: We recommend placing more importance on supportive treatment in patients presenting with hip fractures, especially in those with malnutrition; performing surgical in-tervention as early as possible; and more closely following up with patients with the aforementioned risk factors. © 2023 by The Korean Geriatrics Society

An eleven-year cohort of bloodstream infections in 552 febrile neutropenic patients: resistance profiles of Gram-negative bacteria as a predictor of mortality.

Antimicrobial stewardship is of major importance in patients with febrile neutropenia (FN). In this study, we aimed to investigate the trends in resistance and the relationship with mortality rates in patients with FN. The single-center surveillance data of inpatients with FN and diagnosed as microbiologically confirmed bloodstream infections (BSIs) between 2006 and 2016 were reviewed retrospectively. A total of 950 episodes in 552 patients with BSIs were analyzed. Of whom, 55.9% were male, the median age was 43 years, and 35.6% had acute myeloid leukemia. In total, 1016 microorganisms were isolated from blood cultures. Gram-negatives accounted for 42.4% (n = 403) of the episodes. Among Gram-negatives,Enterobacteriaceaeaccounted for 346 (86%) (E. coli,n = 197; 34% extended-spectrum beta-lactamases (ESBL) producers, andKlebsiella spp.,n = 120; 48.3% ESBL producers). Also, 24 (20.0%) ofKlebsiella spp.had carbapenemase activity. There were 6 (5.0%) colistin-resistantKlebsiella spp. Thirteen (26.5%) ofPseudomonas spp.and 17 (60.7%) ofAcinetobacter spp.had carbapenemase activity. There were 2 (5.6%) colistin-resistantAcinetobacter spp. The 30-day mortality rates were 12.0%, 21.5%, 34.6%, and 29.0% in BSIs due to Gram-positive, Gram-negative bacterial, fungal, and polymicrobial etiology respectively (p = 0.001). BSIs with ESBL-producing (p = 0.001) isolates, carbapenem (p < 0.001), and colistin-resistant isolates (p < 0.001) were associated with increased mortality risk. The tremendous rise in resistance rates among Gram-negatives is dreadfully related to increasing mortality and leads to sharp shifts toward extreme restrictions of unnecessary antibiotic uses. Antimicrobial stewardship in patients with FN requires vigilance and tailoring of treatment upon local surveillance data