3 research outputs found
Efekt interference v lipidovĂ© signálnĂ cestÄ› na cytotoxicitu sorafenibu a funkci efluxnĂch transportĂ©rĹŻ u bunÄ›k myšĂho hepatocelulárnĂho karcinomu
Univerzita Karlova Farmaceutická fakulta v Hradci KrálovĂ© Katedra farmakologie a toxikologie Studentka: Aigul Sagandykova Ĺ kolitel: PharmDr. Martina ÄŚeÄŤková Ph.D. Konzultant: Dr. Mikko Gynther Ph.D. Název diplomovĂ© práce: Efekt interference v lipidovĂ© signálnĂ cestÄ› na cytotoxicitu sorafenibu a funkci efluxnĂch transportĂ©rĹŻ u bunÄ›k myšĂho hepatocelulárnĂho karcinomu. Nádorová onemocnÄ›nĂ pĹ™edstavujĂ i v souÄŤasnĂ© dobÄ› jednu z celosvÄ›tovÄ› nejvĂ˝znamnÄ›jšĂch terapeutickĂ˝ch vĂ˝zev. Chemoterapie dosud zĹŻstává základnĂm pĹ™Ăstupem v lĂ©ÄŤbÄ› malignĂch onemocnÄ›nĂ. JejĂ lĂ©ÄŤebnĂ© vĂ˝sledky nicmĂ©nÄ› komplikuje mnohoÄŤetná lĂ©ková rezistence (MDR), fenomĂ©n popsanĂ˝ jako ztráta citlivosti nádorovĂ˝ch bunÄ›k vĹŻÄŤi širokĂ©mu spektru chemoterapeutickĂ˝ch lĂ©ÄŤiv. DobĹ™e známou pĹ™ĂÄŤinou MDR je zvýšenĂ exprese a/nebo zvýšenĂ aktivity efluxnĂch lĂ©kovĂ˝ch transportĂ©rĹŻ ATP-dependentnĂ transportĂ©rovĂ© rodiny (tzv. ABC transportĂ©rĹŻ), jeĹľ byly nalezeny v mnoha typech nádorĹŻ. V poslednĂm desetiletĂ stále vÄ›tšà mnoĹľstvĂ vÄ›deckĂ© literatury vÄ›nuje pozornost novĂ©mu znaku nádorovĂ˝ch bunÄ›k - zánÄ›tu. ZánÄ›tlivĂ© mikroprostĹ™edĂ potencuje tumorigenezi a up regulaci transportĂ©rĹŻ. NavĂc Ĺ™ada pozorovánĂ potvrzuje, Ĺľe ABC transportĂ©ry zprostĹ™edkovávajĂ pĹ™enos signálnĂch lipidĹŻ. Tento novĂ˝ pohled vede k moĹľnosti volby protizánÄ›tlivĂ© lĂ©ÄŤby jako novĂ©ho pĹ™Ăstupu v...Charles University Faculty of Pharmacy in Hradec KrálovĂ© Department of Pharmacology & Toxicology Student: Aigul Sagandykova Supervisor: PharmDr. Martina ÄŚeÄŤková, Ph.D. Consultant: Dr. Mikko Gynther Ph.D. Title of diploma thesis: The effect of lipid signalling pathway interference on sorafenib cytotoxic efficacy and function of efflux transporters in mouse hepatocellular carcinoma cells. Nowadays cancer remains one of the most challenging health issues worldwide. Chemotherapy represents one of the essential approaches in the treatment of malignant diseases. However, multidrug resistance (MDR), a multifactorial phenomenon described as a loss of sensitivity of cancer cells to several diverse chemotherapeutic agents at the same time, often compromises the therapy outcomes. A well-known cause of MDR is an increased expression or/and an enhanced activity of efflux drug transporters of ATP binding cassette (ABC) superfamily, which has been found in many types of cancer. In the last decade, an expanding body of literature suggested a new hallmark of cancer cells - inflammation. An inflammatory microenvironment potentiates tumorigenesis and upregulation of transporters. Moreover, several observations show that ABC transporters mediate the transport of some signalling lipids. This new insight provided...Katedra farmakologie a toxikologieDepartment of Pharmacology and ToxicologyFarmaceutická fakulta v Hradci KrálovĂ©Faculty of Pharmacy in Hradec Králov
The effect of lipid signaling pathway interference on sorafenib cytotoxic efficacy and function of efflux transporters in mouse hepatocellular carcinoma cells
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Aigul Sagandykova Supervisor: PharmDr. Martina Čečková, Ph.D. Consultant: Dr. Mikko Gynther Ph.D. Title of diploma thesis: The effect of lipid signalling pathway interference on sorafenib cytotoxic efficacy and function of efflux transporters in mouse hepatocellular carcinoma cells. Nowadays cancer remains one of the most challenging health issues worldwide. Chemotherapy represents one of the essential approaches in the treatment of malignant diseases. However, multidrug resistance (MDR), a multifactorial phenomenon described as a loss of sensitivity of cancer cells to several diverse chemotherapeutic agents at the same time, often compromises the therapy outcomes. A well-known cause of MDR is an increased expression or/and an enhanced activity of efflux drug transporters of ATP binding cassette (ABC) superfamily, which has been found in many types of cancer. In the last decade, an expanding body of literature suggested a new hallmark of cancer cells - inflammation. An inflammatory microenvironment potentiates tumorigenesis and upregulation of transporters. Moreover, several observations show that ABC transporters mediate the transport of some signalling lipids. This new insight provided..
The effect of lipid signaling pathway interference on sorafenib cytotoxic efficacy and function of efflux transporters in mouse hepatocellular carcinoma cells
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Aigul Sagandykova Supervisor: PharmDr. Martina Čečková, Ph.D. Consultant: Dr. Mikko Gynther Ph.D. Title of diploma thesis: The effect of lipid signalling pathway interference on sorafenib cytotoxic efficacy and function of efflux transporters in mouse hepatocellular carcinoma cells. Nowadays cancer remains one of the most challenging health issues worldwide. Chemotherapy represents one of the essential approaches in the treatment of malignant diseases. However, multidrug resistance (MDR), a multifactorial phenomenon described as a loss of sensitivity of cancer cells to several diverse chemotherapeutic agents at the same time, often compromises the therapy outcomes. A well-known cause of MDR is an increased expression or/and an enhanced activity of efflux drug transporters of ATP binding cassette (ABC) superfamily, which has been found in many types of cancer. In the last decade, an expanding body of literature suggested a new hallmark of cancer cells - inflammation. An inflammatory microenvironment potentiates tumorigenesis and upregulation of transporters. Moreover, several observations show that ABC transporters mediate the transport of some signalling lipids. This new insight provided..