155 research outputs found
Perspectives of using sodium alginate with different molecular weight in the complex cancer therapy
The article presents the results of screening research of influence of sodium alginate with different molecular weight on the development of transplantable tumor in mice and the effectiveness of cytostatic treatment. It was determined that sodium alginates with both high (Π = 403 kDa) and low (M = 1-10 kDa and M = 1 kDa) molecular weight suppress growth of Ehrlich ascites carcinoma; using sodium alginate (M = 20-30 kDa) in the scheme of chemotherapy increases effectiveness of treatment. Alginates with low molecular weight arrest development of dissemination of Lewis lung carcinoma and sodium alginates (M = 403 kDa and M = 20-30 kDa) in combination with cyclophosphan increase its antimetastatic effect
Research of viscous characteristics of soya lecithin solutions
The viscosity properties of aqueous solutions of soya lecithin, which is a component of dosage forms and has a wide range of functions for a living organism, were studied. The viscometric and pycnometric measurement methods were used in laboratory studies. The study showed that the concentration dependences of the relative viscosity of aqueous solutions of soya lecithin at a concentration not exceeding 2% are described by the Einsteinβs equation adjusted for the magnitude and physical meaning of the coefficients. The relative viscosity of such solutions is practically independent of temperature in the range from 8Β°C to 30Β°C. The temperature begins to play a significant role in changing the system viscosity at a soya lecithin concentration above 5%. Research results can be used to predict the properties of dosage forms during their storage and application.ΠΠ·ΡΡΠ΅Π½Ρ Π²ΡΠ·ΠΊΠΎΡΡΠ½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° Π²ΠΎΠ΄Π½ΡΡ
ΡΠ°ΡΡΠ²ΠΎΡΠΎΠ² Π»Π΅ΡΠΈΡΠΈΠ½Π°ΡΠΎΠ΅Π²ΠΎΠ³ΠΎ, ΡΠ²Π»ΡΡΡΠ΅Π³ΠΎΡΡ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠΌ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΡ
ΡΠΎΡΠΌ ΠΈ ΠΈΠΌΠ΅ΡΡΠ΅Π³ΠΎ ΡΠΈΡΠΎΠΊΠΈΠΉΡΠΏΠ΅ΠΊΡΡ ΡΡΠ½ΠΊΡΠΈΠΉ Π΄Π»Ρ ΠΆΠΈΠ²ΠΎΠ³ΠΎ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ°. ΠΡΠΈ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡΡ
ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ Π²ΠΈΡΠΊΠΎΠ·ΠΈΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΈ ΠΏΠΈΠΊΠ½ΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΌΠ΅ΡΠΎΠ΄Ρ ΠΈΠ·ΠΌΠ΅ΡΠ΅Π½ΠΈΠΉ.ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΎΠ½Π½ΡΠ΅ Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ Π²ΡΠ·ΠΊΠΎΡΡΠΈ Π²ΠΎΠ΄Π½ΡΡ
ΡΠ°ΡΡΠ²ΠΎΡΠΎΠ² Π»Π΅ΡΠΈΡΠΈΠ½Π° ΡΠΎΠ΅Π²ΠΎΠ³ΠΎ ΠΏΡΠΈ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ, Π½Π΅ ΠΏΡΠ΅Π²ΡΡΠ°ΡΡΠ΅ΠΉ 2%, ΠΎΠΏΠΈΡΡΠ²Π°ΡΡΡΡ ΡΡΠ°Π²Π½Π΅Π½ΠΈΠ΅ΠΌ ΠΠΉΠ½ΡΡΠ΅ΠΉΠ½Π° Ρ ΠΏΠΎΠΏΡΠ°Π²ΠΊΠΎΠΉ Π½Π° Π²Π΅Π»ΠΈΡΠΈΠ½Ρ ΠΈ ΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠΌΡΡΠ» ΠΊΠΎΡΡΡΠΈΡΠΈΠ΅Π½ΡΠΎΠ². ΠΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½Π°Ρ Π²ΡΠ·ΠΊΠΎΡΡΡ ΡΠ°ΠΊΠΈΡ
ΡΠ°ΡΡΠ²ΠΎΡΠΎΠ² ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈ Π½Π΅Π·Π°Π²ΠΈΡΠΈΡ ΠΎΡ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΡ Π² ΠΈΠ½ΡΠ΅ΡΠ²Π°Π»Π΅ ΠΎΡ 8ΠΎΠ‘ Π΄ΠΎ 30ΠΎΠ‘. Π‘ΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ ΡΠΎΠ»Ρ Π²ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΈ Π²ΡΠ·ΠΊΠΎΡΡΠΈ ΡΠΈΡΡΠ΅ΠΌΡ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΠ° Π½Π°ΡΠΈΠ½Π°Π΅Ρ ΠΈΠ³ΡΠ°ΡΡ ΠΏΡΠΈ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ Π»Π΅ΡΠΈΡΠΈΠ½Π° ΡΠΎΠ΅Π²ΠΎΠ³ΠΎ Π±ΠΎΠ»Π΅Π΅ 5%. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ Π΄Π»Ρ ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠ²ΠΎΠΉΡΡΠ² Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² ΠΏΡΠΈ ΠΈΡ
Ρ
ΡΠ°Π½Π΅Π½ΠΈΠΈ ΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠΈ
Improvement of radiopurity level of enriched CdWO and ZnWO crystal scintillators by recrystallization
As low as possible radioactive contamination of a detector plays a crucial
role to improve sensitivity of a double beta decay experiment. The radioactive
contamination of a sample of CdWO crystal scintillator by thorium
was reduced by a factor , down to the level 0.01 mBq/kg
(Th), by exploiting the recrystallization procedure. The total alpha
activity of uranium and thorium daughters was reduced by a factor ,
down to 1.6 mBq/kg. No change in the specific activity (the total
activity and Th) was observed in a sample of ZnWO crystal produced
by recrystallization after removing mm surface layer of the
crystal.Comment: 14 pages, 5 figures and 2 table
ΠΠ½Π°Π»ΠΈΠ· ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΊΠ»Π΅ΡΠΎΠΊ Π² ΠΌΠΈΠΊΡΠΎΡΠ°ΡΡΠΈΡΠ°Ρ , ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ ΠΈΠ· Π΄Π΅ΡΠ΅Π»Π»ΡΠ»ΡΡΠΈΠ·ΠΎΠ²Π°Π½Π½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ ΠΏΠ΅ΡΠ΅Π½ΠΈ ΠΈ ΠΏΠΎΡΠΊΠΈ
Aim. To develop the protocols for liver and kidney tissue decellularization, and to develop an analysis of the proliferative activity of human Hep-G2 hepatocarcinoma cells on various carriers.Materials and methods. Decellularization of the liver and kidneys was performed by perfusion of detergent solutions with gradually increasing concentrations of Triton X-100 (1, 2 and 3%). A histological analysis of the obtained samples was performed, and the method of optical and scanning electron microscopy was used to study the obtained samples. The proliferative activity of human Hep-G2 hepatocarcinoma cells was studied on the obtained samples of decellularized liver and kidney tissue.Results. Decellularization of the organ does not lead to changes in the specific structure of the tissue matrix. Microparticles with an average size of 200 ΞΌm were made from their decellularized matrix of liver and kidney tissues. The level of proliferative activity of human Hep-G2 hepatocarcinoma cells cultured on microparticles from a decellularized liver was significantly higher than on microparticles from a decellularized kidney.Conclusion. The decellularized matrix retains the native three-dimensional structure of the tissue. The level of cell proliferative activity is significantly higher on microparticles from the decellularized liver, which confirms the preservation of the specificity of the extracellular matrix of the tissue after the process of decellularization.Π¦Π΅Π»Ρ. Π Π°Π·ΡΠ°Π±ΠΎΡΠΊΠ° ΠΏΡΠΎΡΠΎΠΊΠΎΠ»ΠΎΠ² Π΄Π΅ΡΠ΅Π»Π»ΡΠ»ΡΡΠΈΠ·Π°ΡΠΈΠΈ ΡΠΊΠ°Π½ΠΈ ΠΏΠ΅ΡΠ΅Π½ΠΈ ΠΈ ΠΏΠΎΡΠ΅ΠΊ, Π° ΡΠ°ΠΊΠΆΠ΅ Π°Π½Π°Π»ΠΈΠ· ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΊΠ»Π΅ΡΠΎΠΊ Π³Π΅ΠΏΠ°ΡΠΎΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° Hep-G2 Π½Π° ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
Π½ΠΎΡΠΈΡΠ΅Π»ΡΡ
.ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠ΅ΡΠ΅Π»Π»ΡΠ»ΡΡΠΈΠ·Π°ΡΠΈΡ ΠΏΠ΅ΡΠ΅Π½ΠΈ ΠΈ ΠΏΠΎΡΠ΅ΠΊ Π±ΡΠ»Π° ΠΏΡΠΎΠΈΠ·Π²Π΅Π΄Π΅Π½Π° ΠΏΡΡΠ΅ΠΌ ΠΏΠ΅ΡΡΡΠ·ΠΈΠΈ ΡΠ°ΡΡΠ²ΠΎΡΠΎΠ² Π΄Π΅ΡΠ΅ΡΠ³Π΅Π½ΡΠΎΠ² Ρ ΠΏΠΎΡΡΠ΅ΠΏΠ΅Π½Π½ΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΠ°ΡΡΠΈΠΌΠΈ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡΠΌΠΈ Π’ΡΠΈΡΠΎΠ½Π° Π₯-100 (1, 2 ΠΈ 3%). ΠΡΠ» ΠΏΡΠΎΠΈΠ·Π²Π΅Π΄Π΅Π½ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΉ Π°Π½Π°Π»ΠΈΠ· ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
ΠΎΠ±ΡΠ°Π·ΡΠΎΠ², ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ ΠΌΠ΅ΡΠΎΠ΄ ΠΎΠΏΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΈ ΡΠΊΠ°Π½ΠΈΡΡΡΡΠ΅ΠΉ ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΠΎΠΉ ΠΌΠΈΠΊΡΠΎΡΠΊΠΎΠΏΠΈΠΈ Π΄Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
ΠΎΠ±ΡΠ°Π·ΡΠΎΠ². ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π° ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠ²Π½Π°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ Π³Π΅ΠΏΠ°ΡΠΎΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° Hep-G2 Π½Π° ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
ΠΎΠ±ΡΠ°Π·ΡΠ°Ρ
Π΄Π΅ΡΠ΅Π»Π»ΡΠ»ΡΡΠΈΠ·ΠΎΠ²Π°Π½Π½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ ΠΏΠ΅ΡΠ΅Π½ΠΈ ΠΈ ΠΏΠΎΡΠΊΠΈ.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΠ΅ΡΠ΅Π»Π»ΡΠ»ΡΡΠΈΠ·Π°ΡΠΈΡ ΠΎΡΠ³Π°Π½Π° Π½Π΅ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡΠΌ Π² ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΡΡΠΊΡΡΡΠ΅ ΠΌΠ°ΡΡΠΈΠΊΡΠ° ΡΠΊΠ°Π½ΠΈ. ΠΠΈΠΊΡΠΎΡΠ°ΡΡΠΈΡΡ ΡΠΎ ΡΡΠ΅Π΄Π½ΠΈΠΌ ΡΠ°Π·ΠΌΠ΅ΡΠΎΠΌ 200 ΠΌΠΊΠΌ Π±ΡΠ»ΠΈ ΠΈΠ·Π³ΠΎΡΠΎΠ²Π»Π΅Π½Ρ ΠΈΠ· Π΄Π΅ΡΠ΅Π»Π»ΡΠ»ΡΡΠΈΠ·ΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΠΌΠ°ΡΡΠΈΠΊΡΠ° ΡΠΊΠ°Π½Π΅ΠΉ ΠΏΠ΅ΡΠ΅Π½ΠΈ ΠΈ ΠΏΠΎΡΠΊΠΈ. Π£ΡΠΎΠ²Π΅Π½Ρ ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΊΠ»Π΅ΡΠΎΠΊ Π³Π΅ΠΏΠ°ΡΠΎΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° Hep-G2 , ΠΊΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
Π½Π° ΠΌΠΈΠΊΡΠΎΡΠ°ΡΡΠΈΡΠ°Ρ
ΠΈΠ· Π΄Π΅ΡΠ΅Π»Π»ΡΠ»ΡΡΠΈΠ·ΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΏΠ΅ΡΠ΅Π½ΠΈ, Π±ΡΠ» ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ Π²ΡΡΠ΅, ΡΠ΅ΠΌ Π½Π° ΠΌΠΈΠΊΡΠΎΡΠ°ΡΡΠΈΡΠ°Ρ
ΠΈΠ· Π΄Π΅ΡΠ΅Π»Π»ΡΠ»ΡΡΠΈΠ·ΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΏΠΎΡΠΊΠΈ.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΠ΅ΡΠ΅Π»Π»ΡΠ»ΡΡΠΈΠ·ΠΎΠ²Π°Π½Π½ΡΠΉ ΠΌΠ°ΡΡΠΈΠΊΡ ΡΠΎΡ
ΡΠ°Π½ΡΠ΅Ρ Π½Π°ΡΠΈΠ²Π½ΡΡ ΡΡΠ΅Ρ
ΠΌΠ΅ΡΠ½ΡΡ ΡΡΡΡΠΊΡΡΡΡ ΡΠΊΠ°Π½ΠΈ. Π£ΡΠΎΠ²Π΅Π½Ρ ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΊΠ»Π΅ΡΠΎΠΊ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ Π²ΡΡΠ΅ Π½Π° ΠΌΠΈΠΊΡΠΎΡΠ°ΡΡΠΈΡΠ°Ρ
ΠΈΠ· Π΄Π΅ΡΠ΅Π»Π»ΡΠ»ΡΡΠΈΠ·ΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΏΠ΅ΡΠ΅Π½ΠΈ, ΡΡΠΎ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π°Π΅Ρ ΡΠΎΡ
ΡΠ°Π½Π½ΠΎΡΡΡ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΠΎΡΡΠΈ ΠΌΠ΅ΠΆΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΌΠ°ΡΡΠΈΠΊΡΠ° ΡΠΊΠ°Π½ΠΈ ΠΏΠΎΡΠ»Π΅ ΠΏΡΠΎΡΠ΅ΡΡΠ° Π΄Π΅ΡΠ΅Π»Π»ΡΠ»ΡΡΠΈΠ·Π°ΡΠΈΠΈ
ΠΠΈΠΎΠ΄Π΅Π³ΡΠ°Π΄ΠΈΡΡΠ΅ΠΌΡΠ΅ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΡΠΊΠ°Π½Π΅ΠΉ ΠΈΠ· Π½Π°ΡΡΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ΅Π»ΠΊΠ° ΠΊΠ°ΠΊ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΠ΅ ΡΠΊΠ°ΡΡΠΎΠ»Π΄Ρ Π΄Π»Ρ ΡΠΊΠ°Π½Π΅Π²ΠΎΠΉ ΠΈΠ½ΠΆΠ΅Π½Π΅ΡΠΈΠΈ ΠΈ ΡΠ΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΠ²Π½ΠΎΠΉ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½Ρ
Objective: to develop a method for obtaining scaffolds based on natural silk fabric and to study their biocompatibility in vitro. Materials and methods. To obtain biodegradable scaffolds based on natural silk fabric, weΒ propose treating natural silk fabric with a water-ethanol solution of calcium chloride. Differences in the structureΒ of the resulting scaffolds were identified via scanning electron microscopy. Conclusion. The resulting scaffoldsΒ are non-toxic to cells and support cell adhesion and proliferation. Our studies make it possible to consider theΒ resulting biodegradable scaffolds as promising constructs for tissue engineering and regenerative medicine.Π¦Π΅Π»ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π±ΡΠ»Π° ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ° ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠΈ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ ΡΠΊΠ°ΡΡΠΎΠ»Π΄ΠΎΠ² Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΡΠΊΠ°Π½ΠΈ ΠΈΠ· Π½Π°ΡΡΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎΒ ΡΠ΅Π»ΠΊΠ° ΠΈ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΈΡ
Π±ΠΈΠΎΡΠΎΠ²ΠΌΠ΅ΡΡΠΈΠΌΠΎΡΡΠΈ in vitro. ΠΠ»Ρ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ Π±ΠΈΠΎΠ΄Π΅Π³ΡΠ°Π΄ΠΈΡΡΠ΅ΠΌΡΡ
ΡΠΊΠ°ΡΡΠΎΠ»Π΄ΠΎΠ² Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΡΠΊΠ°Π½ΠΈ ΠΈΠ· Π½Π°ΡΡΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ΅Π»ΠΊΠ° ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Π°Β ΠΎΠ±ΡΠ°Π±ΠΎΡΠΊΠ° ΡΠΊΠ°Π½Π΅ΠΉ ΠΈΠ· Π½Π°ΡΡΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ΅Π»ΠΊΠ° Π²ΠΎΠ΄Π½ΠΎ-ΡΠΏΠΈΡΡΠΎΠ²ΡΠΌΒ ΡΠ°ΡΡΠ²ΠΎΡΠΎΠΌ Ρ
Π»ΠΎΡΠΈΠ΄Π° ΠΊΠ°Π»ΡΡΠΈΡ. ΠΠ΅ΡΠΎΠ΄ΠΎΠΌ ΡΠΊΠ°Π½ΠΈΡΡΡΡΠ΅ΠΉ ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΠΎΠΉ ΠΌΠΈΠΊΡΠΎΡΠΊΠΎΠΏΠΈΠΈ Π²ΡΡΠ²Π»Π΅Π½Ρ ΡΠ°Π·Π»ΠΈΡΠΈΡ Π²Β ΡΡΡΡΠΊΡΡΡΠ΅ ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
ΡΠΊΠ°ΡΡΠΎΠ»Π΄ΠΎΠ². ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ ΡΠΊΠ°ΡΡΠΎΠ»Π΄Ρ Π½Π΅ ΡΠ²Π»ΡΡΡΡΡ ΡΠΎΠΊΡΠΈΡΠ½ΡΠΌΠΈ Π΄Π»Ρ ΠΊΠ»Π΅ΡΠΎΠΊ, Π°Β ΡΠ°ΠΊΠΆΠ΅Β ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠΈΠ²Π°ΡΡ Π°Π΄Π³Π΅Π·ΠΈΡ ΠΈ ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΡ ΠΊΠ»Π΅ΡΠΎΠΊ. ΠΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°ΡΡΒ ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ Π±ΠΈΠΎΠ΄Π΅Π³ΡΠ°Π΄ΠΈΡΡΠ΅ΠΌΡΠ΅ ΡΠΊΠ°ΡΡΠΎΠ»Π΄Ρ ΠΊΠ°ΠΊ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΠ΅ ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠΈ Π΄Π»Ρ ΡΠΊΠ°Π½Π΅Π²ΠΎΠΉ ΠΈΠ½ΠΆΠ΅Π½Π΅ΡΠΈΠΈ ΠΈΒ ΡΠ΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΠ²Π½ΠΎΠΉ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½Ρ
The efficiency of tear substitute therapy at dysfunction tear basic secretion
Purpose: to evaluate the efficiency and tolerance of drops replacing tear with hyaluronic acid 0.15% (Hylabak, thea, France) for the treatment of tear film diseases, in particular blepharoconjunctival form of dry eye syndrome.Methods: 32 patients (range 38 to 72 years) with blepharoconjunctival form of dry eye syndrome were treated lubricant Hylabak 2-4 times a day during 7-30 days.Results: After treatment was detected the elimination of complaints in 30 of 32 people, increasing the stability of the tear film (increasing values of the samples Norn test from 7.3 Β±0.5 to 10.1Β±0.6 seconds), as well as normalization of Schirmer test (from 8.8Β±0.4 to 15.2Β±0.5 mm).Conclusion: the study was showed high efficacy of lubricant Hylabak and subjective tolerability at blepharoconjunctival form ofΒ dry eye syndrome
IgG4-RELATED DISEASE. CLINICAL NOTES
IgG4-related diseases are a new nosological entity that encompasses a few previously known diseases. IgG4-relatedΒ systemic disease is diagnosed if two or more affected organs are detected. This group of diseases has two similar signs:Β serological (elevated serum IgG4 subclass concentrations) and histological (organ and tissue infiltration from plasmo-cytes secreting IgG4, and eosinophils, and the development of fibrosclerosis and phlebitis obliterans).Β The paper describes two cases. In one case, a multisystemic disease was observed virtually at its onset whereas in theΒ other this lesion was diagnosed several years after the natural course of the disease
The mathematical simulation of the temperature fields of building envelopes under permanent frozen soil conditions
The physical-mathematical model of the thermal state of the aired technical underground taking into account the air exchange and design features of construction under permanent frozen soil conditions has been suggested. The computational scheme of the temperature fields prediction of building envelopes of projected buildings and soil under and nearby buildings has been developed. The numerical simulation of the temperature fields of building envelopes changes was conducted during a year. The results of the numerical simulation showed that the heat coming from the technical undergrounds and through the walls does not influence the temperature field of the soil neither under a building nor at a distance from it
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