Preclinical Cushing's syndrome in adrenal incidentalomas

Adrenal tumors are usually diagnosed by clinical symptoms of hormone excess. The increasing use of ultrasound and computed tomography results in the detection of a substantial number of incidentally discovered adrenal tumors. Most of these tumors are nonfunctional adrenocortical adenomas, but a few cases of subclinical cortisol production in "incidentalomas" have been reported. We investigated prospectively the prevalence of autonomous cortisol production in 68 patients (44 females and 24 males, aged 25-90 yr) with adrenal incidentalomas at our institution. As a screening procedure all patients with incidentalomas underwent an overnight dexamethasone suppression test (1 mg). Patients who failed to suppress serum cortisol below 140 nmol/L (5 micrograms/dL) underwent more comprehensive studies (prolonged dexamethasone suppression test, determination of the diurnal rhythm of cortisol secretion in saliva, and CRH stimulation test). Eight patients (12% of all patients with incidentalomas; 5 females and 3 males, aged 25-71 yr) were finally identified as having cortisol- producing tumors, and the findings in these patients were compared with those of overt Cushing's syndrome in 8 patients (8 females, aged 26-50 yr) suffering from cortisol-producing adrenal adenomas. The tumor size of patients with cortisol-producing incidentalomas ranged from 2-5 cm. No specific signs and symptoms of hypercortisolism were present, but arterial hypertension (seven of eight subjects), diffuse obesity (four of eight subjects), and noninsulin-dependent diabetes mellitus (NIDDM; two of eight subjects) were frequently observed. Baseline cortisol levels were in the normal to upper normal range, whereas baseline ACTH levels were suppressed in five of the eight patients. In none of the patients was serum cortisol suppressible by low dose or high dose dexamethasone. The ACTH and cortisol responses to CRH were normal in two, blunted in one, and suppressed in four patients. Unilateral adrenalectomy was performed in seven patients and resulted in temporary adrenal insufficiency in four of them. After surgery, improvement of arterial hypertension, a permanent weight loss in obese subjects, and a better metabolic control of NIDDM were noted in the majority of patients. The following conclusions were reached. Incidentally diagnosed adrenal tumors with pathological cortisol secretion in otherwise clinically asymptomatic patients are more frequently observed than previously assumed. Adrenocortical insufficiency is a major risk in these patients after adrenalectomy. After surgery, hypertension, obesity, and NIDDM may improve. Patients with asymptomatic adrenal incidentalomas, therefore, should be screened for cortisol production by means of an overnight dexamethasone suppression test

In situ sensors for measurements in the global trosposphere

Current techniques available for the in situ measurement of ambient trace gas species, particulate composition, and particulate size distribution are reviewed. The operational specifications of the various techniques are described. Most of the techniques described are those that have been used in airborne applications or show promise of being adaptable to airborne applications. Some of the instruments described are specialty items that are not commercially-available. In situ measurement techniques for several meteorological parameters important in the study of the distribution and transport of ambient air pollutants are discussed. Some remote measurement techniques for meteorological parameters are also discussed. State-of-the-art measurement capabilities are compared with a list of capabilities and specifications desired by NASA for ambient measurements in the global troposphere

The 1979 Southeastern Virginia Urban Plume Study (SEV-UPS): Surface and airborne studies

The operation of two surface monitoring stations (one in downtown Norfolk, Virginia, one south of the city near the Great Dismal Swamp) and the collection of 40 hours of airborne measurements is described. Surface site measurements of ozone, oxides of nitrogen, sulfur dioxide, temperature, dew point, b sub seat, and condensation nuclei were made. Instrument calibrations, quality assurance audits, and preliminary data analysis in support of the Urban Plume Study were also made. The air pollution problems that were addressed are discussed. Data handling procedures followed for the surface stations are presented. The operation of the aircraft sampling platform is described. Aircraft sampling procedures are discussed. A preliminary descriptive analysis of the aircraft data is given along with data or plots for surface sites, airborne studies, hydrocarbon species, and instrument performance audits. Several of the aircraft flights clearly show the presence of an urban ozone plume downwind of Norfolk in the direction of the mean wind flow

Projective Fourier Duality and Weyl Quantization

The Weyl-Wigner correspondence prescription, which makes large use of Fourier duality, is reexamined from the point of view of Kac algebras, the most general background for noncommutative Fourier analysis allowing for that property. It is shown how the standard Kac structure has to be extended in order to accommodate the physical requirements. An Abelian and a symmetric projective Kac algebras are shown to provide, in close parallel to the standard case, a new dual framework and a well-defined notion of projective Fourier duality for the group of translations on the plane. The Weyl formula arises naturally as an irreducible component of the duality mapping between these projective algebras.Comment: LaTeX 2.09 with NFSS or AMSLaTeX 1.1. 102Kb, 44 pages, no figures. requires subeqnarray.sty, amssymb.sty, amsfonts.sty. Final version with text improvements and crucial typos correction

Fourier Duality as a Quantization Principle

The Weyl-Wigner prescription for quantization on Euclidean phase spaces makes essential use of Fourier duality. The extension of this property to more general phase spaces requires the use of Kac algebras, which provide the necessary background for the implementation of Fourier duality on general locally compact groups. Kac algebras -- and the duality they incorporate -- are consequently examined as candidates for a general quantization framework extending the usual formalism. Using as a test case the simplest non-trivial phase space, the half-plane, it is shown how the structures present in the complete-plane case must be modified. Traces, for example, must be replaced by their noncommutative generalizations - weights - and the correspondence embodied in the Weyl-Wigner formalism is no more complete. Provided the underlying algebraic structure is suitably adapted to each case, Fourier duality is shown to be indeed a very powerful guide to the quantization of general physical systems.Comment: LaTeX 2.09 with NFSS or AMSLaTeX 1.1. 97Kb, 43 pages, no figures. requires subeqnarray.sty, amssymb.sty, amsfonts.sty. Final version with (few) text and (crucial) typos correction