Spectroscopic Study of some Schiff Bases Derived from Dibenzoylmethane

A series of Schiff bases 7-11 derived from dibenzoylmethane have been prepared. The UV, IR, 1H NMR and mass spectra revealed theses compounds were existed mainly as the keto-enamine tautomer in the solution. The absorption bands which appeared in the range λmax = 376-406 nm were assigned to the electronic transitions which arised from the central hydrogen bonded chelated unsaturated ring system in this tautomer. The appearance of the broad singlet near d  = 13 ppm due to the N-H proton and a singlet near d  = 6 ppm due to the –C=C-H proton inaddition to benzoyl fragment ion     signal m/z =105 in the mass spectra supported the above suggested products

Theoretical study on the electronic spectra in cyclic 1,2-diketones

AbstractThe structural and electronic properties of some α-diketones have been investigated theoretically by performing both Hartree–Fock and density functional theory calculations at HF/6-31G(d,p) and B3LYP/6-31G(d,p) levels of theory.The electronic spectra were calculated by ZINDO and TD methods at each level of theory. The wavelength of the n→π∗ electronic transitions was correlated with the torsion angle between the two carbonyl groups in these compounds. The study revealed that the n→π∗ electronic transitions in the studied compounds are functions of the torsion angles between the two carbonyl groups within the linkage CO–CO

Ultrasonic Waves Assisted Synthesis of Curcuminoids Based on 3-Methylacetylacetone and in Situ Synthesis of Gold Nanoparticles Capped with Curcuminoids

Ultrasonic irradiation was used to induce the Knuevenagle reaction between aromatic aldehydes and 3-methylacetylacetone to synthesize curcumin analogues with moderate to good yields. The structures of the compounds were established by elemental analysis and from their mass and 1HNMR spectra. In situ curcumin-gold nanoparticles were synthesized. The solutions of the prepared nanoparticles have purple to deep-red colors and their UV-vis spectra were characterized by the Surface Plasmon Resonance bands within the range 538-554 nanometer

Synthesis, Characterization and Antitumor Activity of Some New Oganotellurium Compounds Containing Azomethine Group, Part One

New tellurated schiff bases were synthesized by the reaction of the corresponding mercurated Schiff  bases compounds A1-A3 with tellurium tetrabromide in 1:1 mole ratio and  that  gave organyltellurium tribromides  A4-A6.  On the other hand, when mercurated schiff bases and tellurium tetrabromide brought  together in 2:1 mole ratio gave diorganyltellurium dibromides compounds A10-A12 followed by reduction with hydrazine hydrate gave new diorganyl tellurides A13-A15.  Reduction of compounds A4-A6 by  hydrazine hydrate gave new ditellurides A7-A9.  All compounds were characterized by elemental analysis, IR, 1H , 13C NMR, HSQC-NMR and mass spectra.  Invitro anti-tumor bioactivity of some compounds were tested.Â

Derivati aminokiselina. Dio 1. Sinteza, antivirusno i antitumorsko djelovanje novih estera alfa-aminokiselina s kumarinskim supstituentom

A series of amino acid esters bearing coumarin (3-15) were synthesized and evaluated, in vitro, against HIV-1, and bovine viral diarrhea virus (BVDV). The in vitro cytotoxicity of 3-10 and 12 were assyed against a panel of tumor cell lines consisting of CD4 human T-cells. Compound 14 showed inhibition of HIV-1 with EC50 > 1.6 microg mL-1, meanewhile compound 9 exhibited activity against leukaemia (MT4) with CC50 = 24 micromol L-1).U radu je opisana sinteza estera aminokiselina s kumarinskim ostatkom 3-15. Ispitano je antivirusno djelovanje sintetiziranih spojeva na HIV-1 i goveđi virus diareje (BVDV) te in vitro citotoksičnost spojeva 3-10 i 12 na tumorskim linijama CD4 humanih T-stanica. Spoj 14 pokazao je inhibiciju HIV-1 s EC50 > 1.6 microg mL-1, dok je spoj 9 djelotvoran na leukemiju (MT4) s CC50 = 24 micromol L-1

Antitumor and Quantitative Structure Activity Relationship Study for Dihydropyridones Derived from Curcumin

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Derivati aminokiselina. Dio 1. Sinteza, antivirusno i antitumorsko djelovanje novih estera alfa-aminokiselina s kumarinskim supstituentom

A series of amino acid esters bearing coumarin (3-15) were synthesized and evaluated, in vitro, against HIV-1, and bovine viral diarrhea virus (BVDV). The in vitro cytotoxicity of 3-10 and 12 were assyed against a panel of tumor cell lines consisting of CD4 human T-cells. Compound 14 showed inhibition of HIV-1 with EC50 > 1.6 microg mL-1, meanewhile compound 9 exhibited activity against leukaemia (MT4) with CC50 = 24 micromol L-1).U radu je opisana sinteza estera aminokiselina s kumarinskim ostatkom 3-15. Ispitano je antivirusno djelovanje sintetiziranih spojeva na HIV-1 i goveđi virus diareje (BVDV) te in vitro citotoksičnost spojeva 3-10 i 12 na tumorskim linijama CD4 humanih T-stanica. Spoj 14 pokazao je inhibiciju HIV-1 s EC50 > 1.6 microg mL-1, dok je spoj 9 djelotvoran na leukemiju (MT4) s CC50 = 24 micromol L-1

Synthesis of Symmetrical and Non-symmetrical Diimines from Dimedone

Symmetrical and non-symmetrical diimines derived from dimedone were synthesized by the reaction of their corresponding enaminothiones with primary amines. The synthesized compounds were characterized using micro analytical data and NMR spectroscopy. Theoretical calculations by B3LYP/6-31G(d,p) level of theory show that the enolic form is the most stable within the possible tautomeric forms of the compounds

Microwave-Assisted Synthesis of Novel 2,3-Dihydro-4-Pyridinones

Novel 2,3-dihydro-4-pyridinones were synthesized via the reaction of curcumin and primary amines or amine acetates under microwave irradiation. Montmorillonite K-10 was used as a catalyst. Reaction times did not exceed 120 s. The structures of the compounds were established by elemental analysis and from their mass, 1H- and 13C-NMR spectra