A Hybrid Peripheral Giant Cell Granuloma-Peripheral Ossifying Fibroma Lesion Presenting as a Solitary Gingival Enlargement

Clinical and radiographic presentations of gingival enlargements often overlap. Definitive diagnosis is made after histological evaluation of excised tissues. Sometimes this is also confusing because it may show features of different clinical entities producing a diagnostic dilemma. Hybrid lesions are lesions which present features from different pathologies. We present a case of hybrid lesion which shows features of peripheral giant cell granuloma (PGCG) and Peripheral ossifying fibroma (POsF) presenting as solitary gingival enlargement involving the maxilla in a 57 year old female patient. The clinical, radiographic and histological features are described in detail. The purpose of this paper is to highlight the importance of thorough evaluation of hybrid lesion to get a proper diagnosis, understand their biologic behaviour and plan treatment to minimise tissue destruction and prevent recurrence. This case also points to the need to reconsider our diagnostic criteria of various enlargements and incorporate hybrid lesions as distinct clinical entit

Spectrochemical studies on the uptake of ions by plants I. The Lundegardh flame technique of ash analysis of toxin/antibiotic invaded cotton plants

Spectrochemical analysis, using the standard Lundegardh flame emission (spark-in-flame) method, of cotton plants infected by Fusarium vasinfectum Atk., showed an increased uptake of Mg, Ca, Fe and Mn with decreased accumulation of K over the healthy plants. It is suggested that the derangement in the selective absorption of ions, seen in the infected plants, is more likely to have been caused by chemical agents (toxins) than physical causes such as plugging of vessels

Wild Arachis Genetic Resources at ICRISAT

The conservatron olArachls germplasm IS an urgent need ICRlSA T hes bean desrgnatd.s a mwot reposrtofy'ol Arrchls germplem. wrth the obwrrves 01 coll~tronm, arnfenance and evaluatron 01 the genetrc resources. end the documentatron and dtstrrbutron 01 mahrral end tnlormatton Wrld specres 01 Arachls are acqurred through transler from known genelrc resocrrce crnlsrs rn Indra end abroad, and elso by collectmg expedrrrons The accessrons whrch reproduce by seed are multrplred by growrng rn Ihe lreld Currently the pods arestored a1 d°C wrlh 35% relrttve hunitdtry Long-term storage lacrlrtres are berng burlt The rhrzometous accessrons ere merntarrved by growing rooted cuftrngs rn concrete conterners A serres oldescrrpfors surfable lor Iheevalualron 01 wtld specres 01 Arachls rs berng developed, meenwhrle the groundnur descrrptors developed by l8PGR end ICRlSA T are berng used At ICRISA T, wrld specres are screened agarnst drseases andpesfs Those specres wtth resrstancr are berng urrlrzed in the Groundnuf lmprovemenl Program Arach~sg ermplasm 1s avatlabte lrbe 01 charge lo all sctentrsts who wrsh to use rt The current status of wrld Arach~s germplasm and the lufure program are presente

Early postoperative outcomes of dunking pancreatojejunostomy

Background: There is no gold standard method for pancreatico-enteric reconstruction.  In our department, dunking pancreatojejunostomy (DPJ) and Duct to mucosa PJ technique are done as per surgeon’s choice.  In this study, authors evaluate the early postoperative outcomes following DPJ based on ISGPS (2007).Methods: A Retrospective analysis of prospectively collected data from January 2008 to December 2015. Detailed information on these patients was maintained on a prospectively held computerized database. Routine drain amylase estimations are being done on POD 3and 5 for all patients undergoing pancreatic resections and on all subsequent days if output is suggestive of pancreatic fistula. Details of patients who have undergone pancreatic resection with duct to mucosa type of pancreato-intestinal anastomosis during the same period (64 patients) were also collected prospectively and analysed. DPJ and Duct to mucosa groups were not comparable with respect to age, duct size, pancreatic gland texture and co-morbidities. Hence direct comparison between the two groups has not been carried out.Results: A total of 75 of 139 pancreatic resections with pancreatointestinal anastomosis who had dunking PJ and fulfilled the study criteria were analysed; none were excluded for analysing early outcomes. 19 out of 75 (25.5%) developed grade ‘A’ POPF, five out of 75 (6.6%) developed Grade ‘B’ POPF and three out of 75 (3.3%) developed Grade ‘C’ POPF. 20 out of 75 (26.6%) had grade ‘A’ DGE, five out of 75 (6.6%) had grade ‘B’ DGE. PPH occurred in four out of 75 (5.3%), two out of four were early PPH, one was managed by coiling and other by re-laparotomy, two were late PPH both managed by coiling of the pseudo aneurysms. There was no 30-day mortality.Conclusions: Dunking (Invagiantion) pancreatojejunostomy has accepatable early outcomes with clinically significant/relevant postoperative pancreatic fistula rates of Grade B (6.6%) and Grade C (4%), delayed gastric emptying (33.2%) and post pancreatic hemorrhage (5.3%) rates. The outcomes are comparable with Duct-to-mucosa PJ mentioned in literature

Synthesis of surfactant free stable nanofluids based on barium hexaferrite by pulsed laser ablation in liquid

Barium hexaferrite nanofluids based on five different solvents have been prepared by employing Pulsed Laser Ablation in Liquid (PLAL) at two different wavelengths of 532 nm and 1064 nm. They were then characterized using Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM), X-ray Photoelectron Spectroscopy (XPS), UV-Vis spectroscopy, and Vibrating Sample Magnetometry (VSM). The chemical states of the ablated nanoparticles were identified from XPS analysis and found to be matching with that of the target. The crystallinity of the nanoparticles were confirmed from high resolution TEM (HRTEM) images and SAED patterns. It is found that different liquid environments lead to the formation of barium ferrite nanoparticles with different particle diameters. The plausible mechanism involved in this process is discussed. This study can pave way for the synthesis of stable magnetic nanofluids of permanent magnets. Further, this technique could be utilized for tailoring the morphology of nanoparticles with a judicious choice of the solvents and other ablation parameter

Mesoporous tertiary oxides via a novel amphiphilic approach

We report a facile biomimetic sol-gel synthesis using the sponge phase formed by the lipid monoolein as a structure-directing template, resulting in high phase purity, mesoporous dysprosium- and gadolinium titanates. The stability of monoolein in a 1,4-butanediol and water mixture complements the use of a simple sol-gel metal oxide synthesis route. By judicious control of the lipid/solvent concentration, the sponge phase of monoolein can be directly realised in the pyrochlore material, leading to a porous metal oxide network with an average pore diameter of 10 nm

Racial differences in the systemic inflammatory response to prostate cancer

Systemic inflammation may increase risk for prostate cancer progression, but the role it plays in prostate cancer susceptibility is unknown. From a cohort of over 10,000 men who had either a prostate biopsy or transurethral resection that yielded a benign finding, we analyzed 517 incident prostate cancer cases identified during follow-up and 373 controls with one or more white blood cell tests during a follow-up period between one and 18 years. Multilevel, multivariable longitudinal models were fit to two measures of systemic inflammation, neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR), to determine NLR and MLR trajectories associated with increased risk for prostate cancer. For both measures, we found no significant differences in the trajectories by case/control status, however in modeling NLR trajectories there was a significant interaction between race (white or Black and case-control status. In race specific models, NLR and MLR values were consistently higher over time among white controls than white cases while case-control differences in NLR and MLR trajectories were not apparent among Black men. When cases were classified as aggressive as compared to non-aggressive, the case-control differences in NLR and MLR values over time among white men were most apparent for non-aggressive cases. For NLR among white men, significant case-control differences were observed for the entire duration of observation for men who had inflammation in their initial prostate specimen. It is possible that, among white men, monitoring of NLR and MLR trajectories after an initial negative biopsy may be useful in monitoring prostate cancer risk

The interplay of growth differentiation factor 15 (GDF15) expression and M2 macrophages during prostate carcinogenesis

M2 (tumor-supportive) macrophages may upregulate growth differentiation factor 15 (GDF15), which is highly expressed in prostate tumors, but the combined utility of these markers as prognostic biomarkers are unclear. We retrospectively studied 90 prostate cancer cases that underwent radical prostatectomy as their primary treatment and were followed for biochemical recurrence (BCR). These cases also had a benign prostate biopsy at least 1 year or more before their prostate cancer surgery. Using computer algorithms to analyze digitalized immunohistochemically stained slides, GDF15 expression and the presence of M2 macrophages based on the relative density of CD204- and CD68-positive macrophages were measured in prostate: (i) benign biopsy, (ii) cancer and (iii) tumor-adjacent benign (TAB) tissue. Both M2 macrophages (P = 0.0004) and GDF15 (P \u3c 0.0001) showed significant inter-region expression differences. Based on a Cox proportional hazards model, GDF15 expression was not associated with BCR but, in men where GDF15 expression differences between cancer and TAB were highest, the risk of BCR was significantly reduced (hazard ratio = 0.26; 95% confidence interval = 0.09-0.94). In addition, cases with high levels of M2 macrophages in prostate cancer had almost a 5-fold increased risk of BCR (P = 0.01). Expression of GDF15 in prostate TAB was associated with M2 macrophage levels in both prostate cancer and TAB and appeared to moderate M2-macrophage-associated BCR risk. In summary, the relationship of GDF15 expression and CD204-positive M2 macrophage levels is different in a prostate tumor environment compared with an earlier benign biopsy and, collectively, these markers may predict aggressive disease