HER2/neu immunohistochemical expression in gastric carcinoma

Background: Gastric carcinoma is a deadly disease with high mortality. A better understanding of the molecular basis of gastric cancer has contributed to the development of rationally designed molecular targeted therapies which will improve the survival rate. A genetic alteration that could help in targeted therapy and prognostication includes Human Epidermal Growth Factor Receptor 2 (HER2/neu) overexpression in gastric carcinoma. The objective of the present study was to identify and evaluate the HER2/neu protein immunohistochemical expression in gastric cancer from biopsies and surgical resection specimens and to evaluate their correlation with histopathological features.Methods: Total/subtotal gastrectomy specimens and gastric biopsies from a tertiary care center in South India were included in the study and assessed by light microscopy and Immunohistochemistry (IHC).Results: HER2/neu overexpression was seen in 28.6% of gastric adenocarcinoma. HER2/neu overexpression was seen in 44.2% of intestinal-type and 20% of mixed type with none of the diffuse type exhibited HER2/neu positivity and this was statistically highly significant with p value of <0.01. HER2/neu positivity was found in 50% well-differentiated and 36.4% moderately differentiated tumors with none of the poorly differentiated tumors exhibiting HER2/neu positivity and this was statistically highly significant with p value of <0.01.Conclusions: This study highlights the importance of the identification of HER2/neu overexpression in gastric adenocarcinoma. This will help in prognostication and identifying patients suitable for novel therapeutic interventions which will help in prolongation of survival of patients with this deadly disease

On the resources of demersal fishes for bottom trawling in inshore waters off Kakinada by small mechanised boats

An attempt is made to assess the available resources of demersal fishes for bottom trawling off Kakinada, in inshore waters. From the experimental fishing operation during 1964-66, the average catch per hour was 52.79 kg for 9.13 m (30') OAL mechanised boat. The catch composition was dominated by prawns and sciaenids forming 45% of the total catch. The average catch per trawling hour was more during the quarter April - June. An assessment on productive depth range has indicated that catch rate is increasing with increase in the depth of fishing

സ്ഥാപന-ഗ്രാമ-ബന്ധിത പരിപാടികളിലൂടെ കാര്‍ഷിക പങ്കാളിത്തവും, തീരദേശ ഗ്രാമവികസനവും - അനുഭവപാഠങ്ങള്‍ (Farmers' participation and the coastal village development : Experiences of Institution-Village-Linkage-Programme ) (Malayalam)

സ്ഥാപന-ഗ്രാമ-ബന്ധിത പരിപാടികളിലൂടെ കാര്‍ഷിക പങ്കാളിത്തവും, തീരദേശ ഗ്രാമവികസനവും - അനുഭവപാഠങ്ങള്‍ (Farmers' participation and the coastal village development : Experiences of Institution-Village-Linkage-Programme ) (Malayalam

Preliminary observations on the lunar and tidal influences on the catches of seer by gill nets

The paper deals with the lunar and tidal influences on the catches of seer by gill nets. The landings during full moon and new moon nights, during low and high tides and during different quarters of the lunar month for three fishing seasons are discussed