Reductive Biotransformation of Ethyl Acetoacetate: A Comparative Studies using Free and Immobilized Whole Yeast Cells

Bioreduction of ethyl acetoacetate with free and immobilized yeast whole cell was achieved by using water and sucrose combination. After detachment from immobilized beads under basic condition, the corresponding ethyl(S)-(+)-3-hydroxybutanoate was isolated with 98 to 100% yield. Immobilized beads of yeast whole cell were prepared at different temperature which affects the morphology and physiology of the beads for the diffusion of the enzyme, which shown the maximum conversion of the substrate to products as compared to the free yeast whole cell

Personality Based Recommendation System Using Social Media

Recommendation system is the reason of success for most of the social media companies as well as e-commerce sites. Giving recommendation to the uses is one of the interesting and challenging tasks nowadays, it helps to generate revenue, to increase number of users, to reduce the searching time for particular item. Recommendation system helps for making interest in user and eventually it increases the popularity of any site. Huge number of items (product, users, movies, songs, hotels etc.) and its feature sets makes it hard to predict the accurate items to the user. It is important to keep all historic data of user as well as all information about the items to generate recommendation. In this paper, the personality of the user is used with the combination on the most popular recommendation techniques like collaborative filtering (CF) and content based filtering (CB) proposed on the amazon review data set. In the first model the personality of the user is calculated by using the big five model on the twitter account. In the second module Collaborative filtering is used to generate the recommendation based on the historic information of the user wherries in third module, Content based filtering is uses to generate recommendation based on the feature set of the item. Pearson-correlation algorithm is applied on both modules and ranking are generated. Finally union of the both vector space are taken as the final recommendation

Use of anti-snake venom and clinical outcomes in snake envenomation: a prospective observational study

Background: The only effective measure to prevent or reverse most of the manifestations of venomous snake-bite is timely administration of antisnake venom (ASV) with or without adjunctive treatment as necessary in each case. But recently several concerns have been raised with regard to use of polyvalent ASV. Hence the present study was conducted to assess use of ASV, early adverse reactions to ASV, adjunctive treatment and clinical outcomes in snake-bite patients, which would help to identify areas of problem and provide basis for planning strategies to increase rational use of drugs.Methods: It was a prospective observational study approved by Institutional Ethics Committee. All indoor patients with systemic manifestations of snake envenomation were included in the study. All participants gave written informed consent. Data was obtained prospectively using a structured case record form. Descriptive statistics was used to express the results.Results: Among 52 patients, snake-bite predominantly affected males (59.62%) than females (40.38%). The most common site of snake-bite was lower limb (65.38%). The main indication for ASV administration was vasculotoxic snake-bite (59.62%). Mean dose of ASV use was 18.21±15.51 vials. Mortality was seen in one patient. Majority of patients (28/52, 53.85%) received ASV in the range of 1-10 vials for the management of snake-bite.Conclusions: The use and dose of ASV was appropriate in vasculotoxic snake-bite while few neurotoxic snake-bite patients needed higher than recommended dose.

Progressive Image Transmission with OFDM over an AWGN Channel

A modified Orthogonal Frequency Division Multiplexing (OFDM) system for robust progressive image transmission is proposed in this paper. A joint source-channel coder (JSC C) is employed in the modified OFDM system. The set partitioning hierarchical trees (SPIHT) used as source code, and The Low-Density Parity-Check (LDPC) used as a channel coder. The SPIHT coder is modified to generate four different groups of bit stream relative to its significances. An unequal error protection (UEP) is suggested for data groups with the LDPC coder. Also, the modified OFDM system includes an adaptive c1ipping technique as a Peak to average power ratio (PAPR) reduction technique for OFDM signal. This proposed PAPR reduction technique is based on adaptive c1ipping for the amplitude of the input signal, where each of signals related to the different four groups of the modified SPTHT coder is clipped with a different c1ipping level according to the group sensitivity. To demonstrate the efficiency of the modified OFDM system with proposed PAPR reduction technique, the simulation results are presented based on bit error rate (BER), the Peak-signal-to-noise ratio (PSNR) and PAPR over AWGN channel.Based on the simulation results, the proposed structure provides a significant improvement in BER and PSNR performances and a reduction in PAPR is achieved.   &nbsp

A MODIFIED Z-SOURCE HALF BRIDGE CONVERTER FOR PHOTOVOLTAIC APPLICATIONS

Now a day’s the rate of energy generated by the renewable energy sources are increasing rapidly. More popular source form these sources is the photovoltaic system source, but this photovoltaic system is now also most costly and a research work is going on to reduce the cost and increase efficiency of photovoltaic system. Half bridge converter system is developed for to convert dc power in to the ac and also boost dc output. Due to less no of switches, complicity of converter has been reduced

Haemangiomas and venous malformations of the head and neck: A retrospective analysis of endovascular management in 358 patients

Background: Haemangioma (HM) and venous malformations of the head and neck are formidable lesions as they cause cosmetic deformity and psychological problems. Their surgical excision is difficult and fraught with problems like operative blood loss, incomplete excision, disfigurement and recurrence. Endovascular techniques like sclerotherapy and embolization are increasingly being used in the treatment of these difficult lesions. Objectives: This study was undertaken to analyse the efficacy and safety of endovascular techniques in the treatment of HM and slow flow vascular malformations. Materials and Methods: We retrospectively reviewed the records and clinical photographs of 358 patients of HM and slow flow vascular malformations treated in our institute by endovascular approach over a 15 year period. Pre- and post-treatment photographs were compared and outcomes categorized as complete resolution (>90% reduction), considerable reduction (60-90% reduction), partial reduction (20-60% reduction) and no change (<20% reduction). Results: Complete resolution of the lesion was seen in 30% of the patients while 50% patients showed considerable reduction of the swelling. Complications occurred in 6.4% of patients. Conclusion: We conclude that sclerotherapy is an effective and safe treatment modality for these lesions and may be considered as the primary modality in the treatment of these challenging lesions

E-cigarette, or vaping, product use-associated lung injury in adolescents: a review of imaging features

BACKGROUND: There has been a recent increase in recognition of lung disease related to the use of electronic cigarettes (called vaping ). These patients present with acute respiratory illness following exposure to vaporized cannabis or nicotine products and sometimes require hospitalization and intensive care. We describe the imaging findings of this disease entity in the pediatric population. OBJECTIVE: To describe the radiologic findings of lung injury associated with electronic cigarette use (vaping) in the adolescent pediatric population. MATERIALS AND METHODS: We identified all adolescents with acute respiratory illness and a history of electronic cigarette use who presented at our institution within a 3-month period (June 2019 through August 2019). We excluded adolescents with potential intercurrent pulmonary disease. We reviewed the charts for symptomatology and laboratory and pathology data. In addition, we reviewed the chest radiographs and chest CTs of these adolescents. RESULTS: The review group consisted of 12 teenage pediatric patients (10 boys and 2 girls; mean age 16.9 years, range 16.0-17.7 years) with acute respiratory illness found to have a temporal association with electronic cigarette use for cannabis products, nicotine, or both. Other etiologies for illness in these adolescents had been excluded by clinical and laboratory evaluation. All of the adolescents were admitted to the hospital for treatment. The clinical presentations included dyspnea, abdominal pain and constitutional symptoms. Pulmonary function testing that was performed in all patients during admission or follow-up demonstrated reduced diffusion capacity in 4/12 (33%), an obstructive ventilatory pattern in 4/12 (33%), a restrictive pattern in 1/12 (8%), and a mixed obstructive and restrictive pattern in 2/12 (17%) adolescents. Bronchoalveolar lavage studies, performed in 9 of the 12 adolescents, revealed inflammatory cells and lipid-laden macrophages. All of the patients underwent CT of the chest; the findings were notable for centrilobular ground-glass nodules (11/12; 92%) and confluent ground-glass opacities (12/12; 100%), with frequent subpleural sparing (9/12; 75%). Additionally, 6/12 (50%) adolescents demonstrated small pleural effusions; 6/12 (50%) had mild bronchial wall thickening; 9/12 (75%) had enlarged hilar or mediastinal lymph nodes; and 2/12 (17%) had a small pericardial effusion. CONCLUSION: As seen in our teenage population, e-cigarette, or vaping, product use-associated lung injury (EVALI) is characterized by centrilobular ground-glass nodules and ground-glass opacities with subpleural sparing. The imaging findings are most consistent with acute lung injury resulting from toxic inhalation. Because adolescent pediatric patients might not be forthcoming with their history of electronic cigarette use, it is important for the pediatric radiologist to be aware of the imaging patterns of this disease

An open-label, interventional, single-center, prospective clinical study to evaluate the efficacy and safety of “AHPL/AYTAB/1514” in patients suffering from halitosis

Objectives: The main objective of the study was to assess the efficacy and safety of AHPL/AYTAB/1514 tablet in patients suffering from halitosis. Methodology: Fifty four patients were recruited in the study. Patients were advised to take maximum two tablets or at least one tablet four times a day (depending on tolerability of the drug) orally for 60 days. Patients were called for follow-up on day 15, 30, 45, 60, and 75. Data describing quantitative measures were expressed as mean ± standard deviation comparison of variables representing categorical data were performed using Chi-square test, Student's t-test, or Wilcoxon Sign Rank test. Results: At the end of the treatment, significant reduction in halitosis, gingivitis index, and dental plaque index was observed. Even after stoppage of treatment for 15 days after 60 days of treatment, there was no relapse in halitosis. Few patients experienced sore throat, cough, and common cold during the study, which were resolved with the treatment of AHPL/AYTAB/1514 tablet. No significant change in vital parameters and most of the safety laboratory parameters were observed. No staining on tooth was observed in any patient. Almost all patients showed excellent improvement as per global evaluation done by the physician and patient. Almost all patients showed excellent tolerability to the study drug. Few patients showed mild AE, which were resolved without stoppage of study drug. Conclusion: The study provides good evidence in support of the efficacy and safety of the AHPL/AYTAB/1514 tablet in halitosis