Breast cancer with choriocarcinomatous features

This report describes the case of a 45 year-old patient with breast carcinoma characterized by choriocarcinomatous features, presence of bizarre anaplastic cells with areas of necrosis and multinucleated giant cells. The immuno-histochemical analysis showed positivity for chromogranin and β-HCG. The tumor size was 5.7 cm at the largest axis and it was refractory to initial neo-adjuvant treatment. Mastectomy was performed and after microscopic and immuno-histochemical examination it was diagnosed as carcinoma with choriocarcinomatous features. These lesions are rare and liable to synthesize hormonal substances not specific to breast tissue. Its diagnosis is highly significant to the therapeutic and prognostic approach insofar as these lesions are potentially aggressive.O presente relato descreve um caso de carcinoma mamário em paciente de 45 anos, com diferenciação coriocarcinomatosa, caracterizado por presença de células bizarras, anaplásicas, com áreas de necrose e células gigantes multinucleadas, com imunopositividade para a subunidade β da gonadotrofina coriônica humana (β-HCG) e cromogranina, medindo 5,7 cm no maior eixo, refratário ao tratamento neoadjuvante inicial. Realizada mastectomia, cujo diagnóstico após análises microscópica e imuno-histoquímica concluiu tratar-se de carcinoma com características coriocarcinomatosas. Tais lesões são raras, capazes de sintetizar substâncias hormonais não próprias ao tecido mamário, sendo o diagnóstico de grande importância para a abordagem terapêutica e prognóstica, pois constituem um grupo de lesões potencialmente agressivas.Faculdade de Medicina do ABC Serviço de Patologia da MamaFMABCUniversidade Federal de São Paulo (UNIFESP)UNIFESPFMABC Laboratório de Análises ClínicasUNIFESP, EPM, São Paulo, BrazilSciEL

Breast cancer with choriocarcinomatous features

This report describes the case of a 45 year-old patient with breast carcinoma characterized by choriocarcinomatous features, presence of bizarre anaplastic cells with areas of necrosis and multinucleated giant cells. The immuno-histochemical analysis showed positivity for chromogranin and β-HCG. The tumor size was 5.7 cm at the largest axis and it was refractory to initial neo-adjuvant treatment. Mastectomy was performed and after microscopic and immuno-histochemical examination it was diagnosed as carcinoma with choriocarcinomatous features. These lesions are rare and liable to synthesize hormonal substances not specific to breast tissue. Its diagnosis is highly significant to the therapeutic and prognostic approach insofar as these lesions are potentially aggressive.O presente relato descreve um caso de carcinoma mamário em paciente de 45 anos, com diferenciação coriocarcinomatosa, caracterizado por presença de células bizarras, anaplásicas, com áreas de necrose e células gigantes multinucleadas, com imunopositividade para a subunidade β da gonadotrofina coriônica humana (β-HCG) e cromogranina, medindo 5,7 cm no maior eixo, refratário ao tratamento neoadjuvante inicial. Realizada mastectomia, cujo diagnóstico após análises microscópica e imuno-histoquímica concluiu tratar-se de carcinoma com características coriocarcinomatosas. Tais lesões são raras, capazes de sintetizar substâncias hormonais não próprias ao tecido mamário, sendo o diagnóstico de grande importância para a abordagem terapêutica e prognóstica, pois constituem um grupo de lesões potencialmente agressivas

"Disturbed immagination" e "true political econony". Aspirazioni e sfide tra Architettura e Politica in John Ruskin

Nella sua riflessione sulla politica Ruskin indaga il rapporto tra la libert\ue0 individuale e i meccanismi legati ai processi di industrializzazione. In questa prospettiva solleva questioni e dilemmi di larga portata culturale che pongono l'uomo di fronte al problema della Tecnica, al dinamismo "senza sedimenti memoria" che segna la sua esistenza, alla questione cruciale del limite della sua azione di fronte alla natura e al costruito. Nella medesima prospettiva richiama la necessit\ue0 della cura in luogo del dominio delle cose del mondo, della parsimonia in luogo di un consumo non rispendente alle reali esigenze dell\u2019uomo. Per contro richiama la necessit\ue0 di un impegno attivo verso l'affermazione di quelle spinte vitali - come l\u2019Amore, la Bellezza, Immaginazione \u2013 fonti di inventiva ,che spingono l\u2019azione e la ricerca dell\u2019Umanit\ue0. Queste sono solo alcune delle aspettative e delle sfide, ingenue e necessarie, che Ruskin lascia in eredit\ue0 alla contemporaneit\ue0, su cui si \ue8 inteso riflettere

Modification of the existing maximum residue levels and setting of import tolerances for oxathiapiprolin in various commodities

Abstract In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant Du Pont de Nemours GmbH submitted two requests to the competent national authority in Ireland to modify the existing EU maximum residue levels (MRLs) and to set import tolerances for oxathiapiprolin in various plant commodities in order to accommodate the intended EU uses and the authorised uses of this active substance in China, Canada and the United States. The data submitted in support of the request were found to be sufficient to derive MRL proposals for all crops under consideration, except for Brussels sprouts and peas (without pods), for which residue data were either not submitted or were insufficient to support the use. Adequate analytical methods for enforcement are available to control the residues of oxathiapiprolin in commodities under consideration at the validated limit of quantification (LOQ) of 0.01 mg/kg. Based on the risk assessment results, EFSA concluded that, taking into account the existing and the intended uses, the long‐term intake of residues of oxathiapiprolin is unlikely to present a risk to consumer health

Modification of the existing maximum residue level for fosetyl/phosphonic acid for potatoes and wheat

Abstract In accordance with Article 6 of Regulation (EC) No 396/2005, the applicants Luxembourg Industries (Pamol) Ltd and De Sangosse SAS submitted a request to the competent national authority in France to modify the existing maximum residue level (MRL) for fosetyl/phosphonic acid related to the use of potassium phosphonates on potatoes, wheat and some animal commodities. The data submitted in support of the request were found to be sufficient to derive MRL proposals for the crops under assessments and for animal commodities. Adequate analytical methods for enforcement are available to control the residues of phosphonic acid on the commodities under consideration at the validated limit of quantification (LOQ) of 0.01 mg/kg for high water‐ and dry matrices and at LOQ of 0.1 mg/kg in high acid matrices and in animal matrices and eggs at the validated LOQ of 0.05 mg/kg and in milk at the validated LOQ of 0.01 mg/kg. Based on the risk assessment results, EFSA concluded that the intake of residues resulting from the use of potassium phosphonates according to the reported agricultural practices is unlikely to present a risk to consumers

Review of the existing maximum residue levels for clethodim according to Article 12 of Regulation (EC) No 396/2005

Abstract According to Article 12 of Regulation (EC) No 396/2005, EFSA has reviewed the maximum residue levels (MRLs) currently established at European level for the pesticide active substance clethodim. To assess the occurrence of clethodim residues in plants, processed commodities, rotational crops and livestock, EFSA considered the conclusions derived in the framework of Directive 91/414/EEC, the MRLs established by the Codex Alimentarius Commission and European authorisations reported by Member States (including the supporting residues data). Based on the assessment of the available data, MRL could not be proposed because an overall consumer risk assessment could not be finalised. Risk managers should be made aware that the genotoxic potential of the clethodim metabolite 3‐chloroallyl alcohol, the aglycon of 3‐chlorolallyl alcohol glucoside (M14A/M15A) could not be concluded and no toxicological reference values could be derived for this metabolite. Until a conclusion on the toxicological properties of the metabolite is reached, a decision on the residue definition for risk assessment cannot be made which is a prerequisite to perform a reliable dietary risk assessment

Review of the existing maximum residue levels for bupirimate according to Article 12 of Regulation (EC) No 396/2005

Abstract According to Article 12 of Regulation (EC) No 396/2005, EFSA has reviewed the maximum residue levels (MRLs) currently established at European level for the pesticide active substance bupirimate. To assess the occurrence of bupirimate residues in plants, processed commodities, rotational crops and livestock, EFSA considered the conclusions derived in the framework of Commission Regulation (EC) No 33/2008, as well as the European authorisations reported by Member States (including the supporting residues data). Based on the assessment of the available data, MRL proposals were derived and a consumer risk assessment was carried out. Although no apparent risk to consumers was identified, some information required by the regulatory framework was missing. Hence, the consumer risk assessment is considered indicative only and some MRL proposals derived by EFSA still require further consideration by risk managers

Modification of the existing maximum residue levels for quizalofop (resulting from the use of propaquizafop) in lettuces and salad plants

Abstract In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant Adama Agan Ltd submitted a request to the competent national authority in Italy to modify the existing maximum residue levels (MRLs) for propaquizafop/quizalofop in lettuces and salad plants to accommodate the intended SEU use of propaquizafop. The data submitted in support of the request were found to be sufficient to derive MRL proposals of 0.15 mg/kg for the intended SEU use of propaquizafop for the crops belonging to the crop group of lettuces and salad plants. The MRL proposals are expressed for a common residue definition that covers quizalofop and propaquizafop. Since the EU MRL is set at a higher level of 0.20 mg/kg, no modification of the MRL is currently required for the intended use. Adequate analytical methods for enforcement are available to control the residues of propaquizafop, expressed as quizalofop, in plant matrices under consideration. Based on the risk assessment results, EFSA concluded that the long‐term and short‐term intake of residues occurring in food from the existing uses of quizalofop‐P‐ethyl, quizalofop‐P‐tefuryl and propaquizafop and from the intended use of propaquizafop on lettuces and other salad plants, is unlikely to present a risk to consumer health

Review of the existing maximum residue levels for fluopicolide according to Article 12 of Regulation (EC) No 396/2005

Abstract According to Article 12 of Regulation (EC) No 396/2005, EFSA has reviewed the maximum residue levels (MRLs) currently established at European level for the pesticide active substance fluopicolide. To assess the occurrence of fluopicolide residues in plants, processed commodities, rotational crops and livestock, EFSA considered the conclusions derived in the framework of Directive 91/414/EEC, the MRLs established by the Codex Alimentarius Commission as well as the import tolerances and European authorisations reported by Member States (including the supporting residues data). Based on the assessment of the available data, MRL proposals were derived and a consumer risk assessment was carried out. Some information required by the regulatory framework was missing and a possible acute risk to consumers was identified. Hence, the consumer risk assessment is considered indicative only, some MRL proposals derived by EFSA still require further consideration by risk managers and measures for reduction of the consumer exposure should also be considered