1,764 research outputs found

    Satisfaction with creativity: a study of organisational characteristics and individual motivations

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    In answering the question of what influences satisfaction for creativity in the workplace, this work takes into account the extent to which the organization supports human aspiration to creativity. The empirical model uses survey data encompassing over 4,000 workers in Italian social enterprises. Results show that satisfaction for creativity is supported, at organizational level, by teamwork-oriented action, including the quality of processes, relations and on-the job autonomy. At the individual level, satisfaction for creativity is enhanced by the strength of intrinsic and socially oriented motivations and by competence. The analysis of interaction terms shows that teamwork and workers' intrinsic motivations are complementary in enhancing the perception of creativity-enhancing work settings, while a high degree of required competences appears to substitute good relationships with superiorscreativity, job satisfaction, organizational processes, motivations, teamwork,autonomy, interpersonal relations

    A NEW FRAMEWORK FOR THE ECONOMIC ANALYSIS OF COOPERATIVE FIRMS: Self-defined rules, common resources, motivations, and incentives

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    Cooperatives are characterised by mutual-benefit coordination mechanisms aimed at the fulfilment of individual behaviour and outcomes in cooperatives by bringing together new-institutionalism, behavioural and evolutionary economics. Our framework considers four main dimensions of the governance of cooperative firms: (1) the development and application of self-defined rules by the members of the cooperative; (2) the management, and appropriation of common resources and outcomes; (3) intrinsic motivations and reciprocating behaviours; (4) the implementation of suitable incentive mixes based on inclusion and reciprocity, including both pecuniary and non- pecuniary elements. An example is offered in order to highlight possible problems in the governance of cooperative firms, in particular the processes of distribution and appropriation of surplus. The example aims at introducing the discussion of the new framework of analysis.cooperative firms, common resources, motivations, incentives

    Sex hormones in allergic conjunctivitis: altered levels of circulating androgens and estrogens in children and adolescents with vernal keratoconjunctivitis

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    PURPOSE: Vernal keratoconjunctivitis (VKC) is a chronic allergic disease mainly affecting boys in prepubertal age and usually recovering after puberty. To evaluate a possible role of sex hormones in VKC, serum levels of sex hormones in children and adolescents with VKC were assessed. METHODS: 12 prepubertal and 7 early pubertal boys with active VKC and 6 male patients with VKC in remission phase at late pubertal age and 48 healthy age and sex-matched subjects were included. Serum concentration of estrone, 17 beta-estradiol, dehydroepiandrosterone-sulfate, total testosterone and free testosterone, dihydrotestosterone (DHT), cortisol, delta-4-androstenedione, follicle-stimulating hormone, luteinizing hormone, and sex-hormones binding globuline (SHBG) were evaluated. RESULTS: Serum levels of Estrone were significantly increased in all groups of patients with VKC when compared to healthy controls (P < 0.001). Prepubertal and early pubertal VKC showed a significant decrease in DHT (P = 0.007 and P = 0.028, resp.) and SHBG (P = 0.01 and P = 0.002, resp.) when compared to controls and serum levels of SHBG were increased in late pubertal VKC in remission phase (P = 0.007). CONCLUSIONS AND RELEVANCE: VKC patients have different circulating sex hormone levels in different phases of the disease and when compared to nonallergic subjects. These findings suggest a role played by sex hormones in the pathogenesis and/or activity of VKC

    Comparison of the TaqMan and LightCycler systems in pharmacogenetic testing: evaluation of the CYP2C9*2/*3 polymorphisms.

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    Background: Pharmacogenetic testing for drugmetabolizing enzymes is not yet widely used in clinical practice. Methods: In an attempt to facilitate the application of this procedure, we have compared two real-time PCRbased methods, the TaqMan_ and the LightCycler_ for the pharmacogenetic evaluation of CYP2C9*2/*3 polymorphisms. Results and Conclusion: Both procedures are suitable for pharmacogenetic studies. The TaqMan procedure was less expensive in terms of cost per sample, but the TaqMan apparatus is more expensive than the LightCycler apparatus

    A mathematical model of interleukin-6 dynamics during exercise

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    Physical exercise is known to reduce the chronic inflammatory status that leads to Type 2 Diabetes. Its beneficial effects seem to be exerted trough a primary production of the cytokine Interleukin-6 (IL-6) which triggers a cascade of anti-inflammatory cytokines. Consequently, IL-6 has a central role in the description of the metabolic effects of exercise. The aim of this study was to develop a model of IL-6 dynamics during exercise. A model constituted by two non-linear differential equations is proposed. Since IL-6 production seems to be dependent not only on exercise duration but also on exercise intensity, input to the model is represented by heart rate, which is known to correlate well with exercise intensity. Model implementation in a Matlab-based parametric identification procedure allowed optimization of adjustable characteristic coefficients of IL-6 dynamics during exercise. From the reported results, it can be concluded that this model is a suitable tool to reproduce IL-6 time course during the execution of a physical exercise. This model was the first step of a project aimed at describing the complete immune system response to exercise and at giving a comprehensive sight of the effects that exercise has on the metabolic system

    Management of patients with Graves' disease and orbital involvement: role of spectral domain optical coherence tomography

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    PURPOSE: To investigate the role of choroidal thickness evaluation with spectral domain optical coherence tomography (SDOCT) and enhanced depth imaging (EDI) technique in the management of patients with Graves' disease and orbitopathy (GO). METHODS: Thirty-six eyes of 18 patients with GO and 36 eyes of 18 age-matched control subjects were included in this retrospective observational study. All the subjects underwent a complete ophthalmological evaluation, including clinical activity score (CAS) and exophthalmometry. The SDOCT images of the choroid were obtained by EDI modality. RESULTS: Choroidal thickness was significantly increased in GO than in control eyes (p &lt; 0.01). A significant correlation was found between choroidal thickness and CAS, proptosis, and the duration of disease (p &lt; 0.05). CONCLUSION: This study shows that choroidal thickness, evaluated with EDI-OCT, is significantly increased in patients with GO and correlates with the activity of the disease, proptosis, and duration of the disease. The choroidal thickening may reflect the ocular hemodynamic changes, and enhanced depth imaging optical coherence tomography may be a useful tool for the evaluation of orbital congestion and management of patients with Graves' disease and orbital involvement

    Ergodicity breaking in strong and network-forming glassy system

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    The temperature dependence of the non-ergodicity factor of vitreous GeO2_2, fq(T)f_{q}(T), as deduced from elastic and quasi-elastic neutron scattering experiments, is analyzed. The data are collected in a wide range of temperatures from the glassy phase, up to the glass transition temperature, and well above into the undercooled liquid state. Notwithstanding the investigated system is classified as prototype of strong glass, it is found that the temperature- and the qq-behavior of fq(T)f_{q}(T) follow some of the predictions of Mode Coupling Theory. The experimental data support the hypothesis of the existence of an ergodic to non-ergodic transition occurring also in network forming glassy systems
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