Magnetic properties of PrCu2_2 at high pressure

We report a study of the low-temperature high-pressure phase diagram of the intermetallic compound PrCu$_2$, by means of molecular-field calculations and $^{63,65}$Cu nuclear-quadrupole-resonance (NQR) measurements under pressure. The pressure-induced magnetically-ordered phase can be accounted for by considering the influence of the crystal electric field on the $4f$ electron orbitals of the Pr$^{3+}$ ions and by introducing a pressure-dependent exchange interaction between the corresponding local magnetic moments. Our experimental data suggest that the order in the induced antiferromagnetic phase is incommensurate. The role of magnetic fluctuations both at high and low pressures is also discussed.Comment: 7 pages, 6 figures, submitted to Eur. Phys. J.

Progress towards Bell-type polarization experiment with thermal neutrons

Experimental tests of Bell-type inequalities distinguishing between quantum mechanics and local realistic theories remain of considerable interest if performed on massive particles, for which no conclusive result has yet been obtained. Only two-particle experiments may specifically test the concept of spatial nonlocality in quantum theory, whereas single-particle experiments may generally test the concept of quantum noncontextuality. Here we have performed the first Bell-type experiment with a beam of thermal-neutron pairs in the singlet state of spin, as originally suggested by J. S. Bell. These measurements confirm the quantum-theoretical predictions, in agreement with the results of the well-known polarization experiments carried out on optical photons years ago

Effect of recombinant human nerve growth factor eye drops in patients with dry eye: a phase IIa, open label, multiple-dose study

Background: Dry eye disease (DED) affects more than 14% of the elderly population causing decrease of quality of life, high costs and vision impairment. Current treatments for DED aim at lubricating and controlling inflammation of the ocular surface. Development of novel therapies targeting different pathogenic mechanisms is sought-after. The aim of this study is to evaluate safety and efficacy of recombinant human nerve growth factor (rhNGF) eye drops in patients with DED. Methods: Forty consecutive patients with moderate to severe DED were included in a phase IIa, prospective, open label, multiple-dose, clinical trial to receive rhNGF eye drops at 20 μg/mL (Group 1: G1) or at 4 μg/mL (Group 2: G2) concentrations, two times a day in both eyes for 28 days (NCT02101281). The primary outcomes measures were treatment-emerged adverse events (AE), Symptoms Assessment in Dry Eye (SANDE) scale, ocular surface staining and Schirmer test. Results: Of 40 included patients, 39 completed the trial. Both tested rhNGF eye drop concentrations were safe and well tolerated. Twenty-nine patients experienced at least one AE (14 in G1 and 15 in G2), of which 11 had at least 1 related AE (8 in G1 and 3 in G2). Both frequency and severity of DED symptoms and ocular surface damage showed significant improvement in both groups, while tear function improved only in G1. Conclusions: The data of this study indicate that rhNGF eye drops in both doses is safe and effective in improving symptoms and signs of DED. Randomised clinical trials are ongoing to confirm the therapeutic benefit of rhNGF in DED. Trial registration number: NCT02101281

Comparison of the TaqMan and LightCycler systems in pharmacogenetic testing: evaluation of the CYP2C9*2/*3 polymorphisms.

Background: Pharmacogenetic testing for drugmetabolizing enzymes is not yet widely used in clinical practice. Methods: In an attempt to facilitate the application of this procedure, we have compared two real-time PCRbased methods, the TaqMan_ and the LightCycler_ for the pharmacogenetic evaluation of CYP2C9*2/*3 polymorphisms. Results and Conclusion: Both procedures are suitable for pharmacogenetic studies. The TaqMan procedure was less expensive in terms of cost per sample, but the TaqMan apparatus is more expensive than the LightCycler apparatus

Management of patients with Graves' disease and orbital involvement: role of spectral domain optical coherence tomography

PURPOSE: To investigate the role of choroidal thickness evaluation with spectral domain optical coherence tomography (SDOCT) and enhanced depth imaging (EDI) technique in the management of patients with Graves' disease and orbitopathy (GO). METHODS: Thirty-six eyes of 18 patients with GO and 36 eyes of 18 age-matched control subjects were included in this retrospective observational study. All the subjects underwent a complete ophthalmological evaluation, including clinical activity score (CAS) and exophthalmometry. The SDOCT images of the choroid were obtained by EDI modality. RESULTS: Choroidal thickness was significantly increased in GO than in control eyes (p < 0.01). A significant correlation was found between choroidal thickness and CAS, proptosis, and the duration of disease (p < 0.05). CONCLUSION: This study shows that choroidal thickness, evaluated with EDI-OCT, is significantly increased in patients with GO and correlates with the activity of the disease, proptosis, and duration of the disease. The choroidal thickening may reflect the ocular hemodynamic changes, and enhanced depth imaging optical coherence tomography may be a useful tool for the evaluation of orbital congestion and management of patients with Graves' disease and orbital involvement

Tuning topological disorder in MgB2_{2}

We carried out Raman measurements on neutron-irradiated and Al-doped MgB$_2$ samples. The irradiation-induced topological disorder causes an unexpected appearance of high frequency spectral structures, similar to those observed in lightly Al-doped samples. Our results show that disorder-induced violations of the selection rules are responsible for the modification of the Raman spectrum in both irradiated and Al-doped samples. Theoretical calculations of the phonon density of states support this hypothesis, and demonstrate that the high frequency structures arise mostly from contributions at ${\bf q}\not=0$ of the E$_{2g}$ phonon mode.Comment: 4 pages, 4 figure

A mathematical model of interleukin-6 dynamics during exercise

Physical exercise is known to reduce the chronic inflammatory status that leads to Type 2 Diabetes. Its beneficial effects seem to be exerted trough a primary production of the cytokine Interleukin-6 (IL-6) which triggers a cascade of anti-inflammatory cytokines. Consequently, IL-6 has a central role in the description of the metabolic effects of exercise. The aim of this study was to develop a model of IL-6 dynamics during exercise. A model constituted by two non-linear differential equations is proposed. Since IL-6 production seems to be dependent not only on exercise duration but also on exercise intensity, input to the model is represented by heart rate, which is known to correlate well with exercise intensity. Model implementation in a Matlab-based parametric identification procedure allowed optimization of adjustable characteristic coefficients of IL-6 dynamics during exercise. From the reported results, it can be concluded that this model is a suitable tool to reproduce IL-6 time course during the execution of a physical exercise. This model was the first step of a project aimed at describing the complete immune system response to exercise and at giving a comprehensive sight of the effects that exercise has on the metabolic system

Effect of quasi-bound states on coherent electron transport in twisted nanowires

Quantum transmission spectra of a twisted electron waveguide expose the coupling between traveling and quasi-bound states. Through a direct numerical solution of the open-boundary Schr\"odinger equation we single out the effects of the twist and show how the presence of a localized state leads to a Breit-Wigner or a Fano resonance in the transmission. We also find that the energy of quasi-bound states is increased by the twist, in spite of the constant section area along the waveguide. While the mixing of different transmission channels is expected to reduce the conductance, the shift of localized levels into the traveling-states energy range can reduce their detrimental effects on coherent transport.Comment: 8 pages, 9 color figures, submitte