O uso do Instagram para a Promoção da Saúde: Uma Contribuição da Extensão Universitária

O objetivo deste trabalho foi mostrar o uso do Instagram como ferramenta para promover a extensão universitária no contexto da pandemia da Covid-19. O trabalho foi conduzido de forma remota com reuniões pelo Google Meet e WhatsApp. O público-alvo foram os profissionais, professores e estudantes da área da saúde e população geral. Foram realizadas duas postagens semanais na forma de folders ou vídeos e duas lives no período de um ano. A conta do projeto na rede Instagram, após um ano, possuía 353 seguidores e 2.003 engajamentos. Foram realizadas 106 publicações, entre estas 80,2% (85) folders digitais e 19,8% (21) vídeos. O principal tema dos folders foi Covid-19, seguido por microrganismos e higiene das mãos. O tema Covid-19 passou a ser o foco das publicações devido ao contexto da pandemia. No Dia Mundial de Higienização das Mãos foi postado um vídeo  sobre higienização simples das mãos. Devido à promoção desta postagem, ela teve 60 engajamentos e alcance de 32.720 perfis. De acordo com as estimativas do Instagram, o público do projeto apresenta em sua maioria mulheres 63,4% (224), de 25 a 34 anos, 35,8% (126) e residentes no Brasil 99,3% (351). A rede social Instagram pode estar integrada à extensão universitária auxiliando na disseminação de informações de forma confiável e levando conhecimento básico e técnico para o seu público. Para aumentar o engajamento e alcance das publicações seria interessante investimentos em recursos financeiros para promover os conteúdos

Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19

Neutralizing autoantibodies against type I interferons (IFNs) have been found in some patients with critical coronavirus disease 2019 (COVID-19), the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the prevalence of these antibodies, their longitudinal dynamics across the disease severity scale, and their functional effects on circulating leukocytes remain unknown. Here, in 284 patients with COVID-19, we found type I IFN–specific autoantibodies in peripheral blood samples from 19% of patients with critical disease and 6% of patients with severe disease. We found no type I IFN autoantibodies in individuals with moderate disease. Longitudinal profiling of over 600,000 peripheral blood mononuclear cells using multiplexed single-cell epitope and transcriptome sequencing from 54 patients with COVID-19 and 26 non–COVID-19 controls revealed a lack of type I IFN–stimulated gene (ISG-I) responses in myeloid cells from patients with critical disease. This was especially evident in dendritic cell populations isolated from patients with critical disease producing type I IFN–specific autoantibodies. Moreover, we found elevated expression of the inhibitory receptor leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) on the surface of monocytes isolated from patients with critical disease early in the disease course. LAIR1 expression is inversely correlated with ISG-I expression response in patients with COVID-19 but is not expressed in healthy controls. The deficient ISG-I response observed in patients with critical COVID-19 with and without type I IFN–specific autoantibodies supports a unifying model for disease pathogenesis involving ISG-I suppression through convergent mechanisms

The Early Evolution of Biting–Chewing Performance in Hexapoda

Insects show a plethora of different mandible shapes. It was advocated that these mandible shapes are mainly a function of different feeding habits. This hypothesis was tested on a larger sampling of non-holometabolan biting–chewing insects with additional tests to understand the interplay of mandible function, feeding guild, and phylogeny. The results show that at the studied systematic level, variation in mandible biting–chewing effectivity is regulated to a large extent by phylogenetic history and the configuration of the mandible joints rather than the food preference of a given taxon. Additionally, lineages with multiple mandibular joints such as primary wingless hexapods show a wider functional space occupation of mandibular effectivity than dicondylic insects (= silverfish + winged insects) at significantly different evolutionary rates. The evolution and occupation of a comparably narrow functional performance space of dicondylic insects is surprising given the low effectivity values of this food uptake solution. Possible reasons for this relative evolutionary “stasis” are discussed

Viral to metazoan marine plankton nucleotide sequences from the Tara Oceans expedition

A unique collection of oceanic samples was gathered by the Tara Oceans expeditions (2009-2013), targeting plankton organisms ranging from viruses to metazoans, and providing rich environmental context measurements. Thanks to recent advances in the field of genomics, extensive sequencing has been performed for a deep genomic analysis of this huge collection of samples. A strategy based on different approaches, such as metabarcoding, metagenomics, single-cell genomics and metatranscriptomics, has been chosen for analysis of size-fractionated plankton communities. Here, we provide detailed procedures applied for genomic data generation, from nucleic acids extraction to sequence production, and we describe registries of genomics datasets available at the European Nucleotide Archive (ENA, www.ebi.ac.uk/ena). The association of these metadata to the experimental procedures applied for their generation will help the scientific community to access these data and facilitate their analysis. This paper complements other efforts to provide a full description of experiments and open science resources generated from the Tara Oceans project, further extending their value for the study of the world's planktonic ecosystems

L'éducation à la citoyenneté au prisme du cours d'éducation physique: représentations et pratiques enseignantes

L’éducation à la citoyenneté est au centre des discussions dans beaucoup d’écoles et dans notre société démocratique. Ce mémoire se penche sur le travail des enseignants en éducation physique afin de cerner leurs représentations et mises en pratique de l’éducation à la citoyenneté dans leur cours. Par le biais de deux groupes de discussion, nous avons interrogé des enseignants d’écoles secondaires de profil différent mais de niveau socio-économique proche : l’une est de type général, l’autre de type qualifiant. Après l’observation sociodémographique des professeurs, nous avons analysé leur discours et détaillé les différentes représentations et pratiques considérées. Ensuite, nous avons eu la confirmation des théories de certains auteurs qui soutiennent que des facteurs comme l’âge des professeurs et des élèves ainsi que le contexte d’enseignement exercent une influence sur les représentations. Néanmoins, dans notre contexte d’analyse, nous avons découvert que les pratiques évoluent en fonction du degré dans lequel les professeurs enseignent mais également que l’éducation à la citoyenneté passe au second plan pour les professeurs qui enseignent aux garçons du degré supérieur. Enfin, nous nous sommes rendu compte qu’un programme des études en éducation physique de 2014 prévoit le travail de l’éducation à la citoyenneté essentiellement dans le champ de la coopération socio-motrice. Or l’éducation à la citoyenneté dépasse largement ce champ. Alors que le programme de l’éducation à la citoyenneté sera d’application à la rentrée de septembre 2017, ne faudrait-il pas adapter les programmes d’éducation physique ? Dans le même temps, ne faut-il pas sensibiliser les enseignants à l’éducation à la citoyenneté en considérant l’élève comme un citoyen à l’intérieur d’une école démocratique ?Master [120] en sciences de l'éducation, Université catholique de Louvain, 201

Dual oxidase 1 activity is directly regulated via phosphorylations by the protein kinase A

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Regulation of Duox activities by calcium and phorbol esters

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Congenital hypothyroidism caused by a new mutation in the catalytic site of the H2O2 generating enzyme Duox2

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