L'interaction mère-enfant à 9 mois et l'attachement désorganisé mère-enfant à 15 mois

Mémoire numérisé par la Division de la gestion de documents et des archives de l'Université de Montréal

LINGO1 Variants in the French-Canadian Population

Essential tremor (ET) is a complex genetic disorder for which no causative gene has been found. Recently, a genome-wide association study reported that two variants in the LINGO1 locus were associated to this disease. The aim of the present study was to test if this specific association could be replicated using a French-Canadian cohort of 259 ET patients and 479 ethnically matched controls. Our genotyping results lead us to conclude that no association exists between the key variant rs9652490 and ET (Pcorr = 1.00)

Bridging pre-surgical endocrine therapy for breast cancer during the COVID-19 pandemic: outcomes from the B-MaP-C study

Purpose: The B-MaP-C study investigated changes to breast cancer care that were necessitated by the COVID-19 pandemic. Here we present a follow-up analysis of those patients commenced on bridging endocrine therapy (BrET), whilst they were awaiting surgery due to reprioritisation of resources. Methods: This multicentre, multinational cohort study recruited 6045 patients from the UK, Spain and Portugal during the peak pandemic period (Feb–July 2020). Patients on BrET were followed up to investigate the duration of, and response to, BrET. This included changes in tumour size to reflect downstaging potential, and changes in cellular proliferation (Ki67), as a marker of prognosis. Results: 1094 patients were prescribed BrET, over a median period of 53 days (IQR 32–81 days). The majority of patients (95.6%) had strong ER expression (Allred score 7–8/8). Very few patients required expedited surgery, due to lack of response (1.2%) or due to lack of tolerance/compliance (0.8%). There were small reductions in median tumour size after 3 months’ treatment duration; median of 4 mm [IQR − 20, 4]. In a small subset of patients ( n = 47), a drop in cellular proliferation (Ki67) occurred in 26 patients (55%), from high (Ki67 ≥ 10%) to low (< 10%), with at least one month’s duration of BrET. Discussion: This study describes real-world usage of pre-operative endocrine therapy as necessitated by the pandemic. BrET was found to be tolerable and safe. The data support short-term (≤ 3 months) usage of pre-operative endocrine therapy. Longer-term use should be investigated in future trials

L'interaction mère-enfant à 9 mois et l'attachement désorganisé mère-enfant à 15 mois

Mémoire numérisé par la Division de la gestion de documents et des archives de l'Université de Montréal

Effect of ZnO Nanoparticles Salt Precursors on Structural, Morphological, Optical and MB Photocatalytic Properties Using Hydrothermal Synthesis

ZnO nanoparticles were successfully produced via a simple low cost hydrothermal method using different metal precursors. Zn (CH3COO)2), (Zn (NO3)2) and (ZnCl2) were the source materials. The obtained nanoparticles were investigated by means XRD, SEM and DRS. The XRD exhibited the high crystallinity of the pure ZnO phase with hexagonal wurtzite crystalline structure for all simples excepted for ZnO synthetized from ZnCl2 precursor. The crystallite sizes was estimated in the range of 20-37 nm. The precursor type do not affect the Eg of the nanoparticles. The bandgaps energies were between 3.21-3.22 eV. The type of precursor affect the particles morphology. SEM images revealed different morphologies. The photocatalytic activity of the synthetized ZnO NPs in comparison with that of commercial powder for the methylene blue (MB) degradation under UV irradiation, showed the appropriate activity of nanostructures obtained by Zn (NO3)2 and Zn (CH3COO)2 precursors. The first-order kinetic constant over ZnO from Zn (NO3)2 was 1.9, 3.7 and 1.5 times of ZnO commercial powder, ZnO from ZnCl2 and Zn (CH3COO)2, respectively. The ZnO NPs from Zn (NO3)2 and Zn (CH3COO)2 precursors have the best photocatalytic degradation performance with a degradation rate of 99.3% and 96.4%, respectively. The higher photocatalytic performance was probably due to the larger crystallinity, purity phase and specific morphologies than smaller particle size effect. Thus, the synthetized ZnO nanoparticles by the soft hydrothermal process are a promising candidate for the photocatalytic purposes of dyes from waters.</jats:p

Oversewing/Suturing of the Staple Line During Sleeve Gastrectomy is an Effective and Affordable Staple Line Reinforcement Method. A Meta-Analysis of Randomized Controlled Trials

Abstract Bleeding and leaks are the most ominous postoperative complications after laparoscopic sleeve gastrectomy (LSG). Various staple line reinforcement (SLR) techniques have been innovated as oversewing (OS)/suturing, omentopexy (OP)/gastropexy (GP), buttressing, and gluing. Currently, no high-quality evidence supports the use of one method over the other, or even supports the use of SLR over no SLR. This study aims to compare postoperative outcomes between LSG with OS versus LSG without any SLR.</jats:p