New phosphorus dithioacids and their derivatives containing chiral centers and pharmacophoric groups

© 2016 Taylor & Francis Group, LLC.New phosphorus dithioacids, their ammonium salts and S-silyl and plumbyl derivatives containing asymmetric carbon atoms and pharmacophoric groupswere obtained by the reactions of tetraphosphorus decasulfide and 1,3,2,4-dithiadiphosphetane-2,4-disulfides with chiral natural terpenyl alcohols, diols, carboxylic acid esters, amino acids and monosaccharides as well as synthetic chiral amines and 1-phenylethanol. The biological activity of the ammonium salts and S-esters of phosphorus dithioacids were studied

Borylation of calix[4]resorcinols under ultrasonic irradiation

The use of ultrasonic irradiation in the reactions of trialkyl borates with octahydroxytetraoctyl[l 4] metacyclophane allowed us obtaining tetraalkoxyboratocavitands with higher yields and under milder conditions. We first obtained 1,3,2-dioxaborolane and 1,3,2-dioxaborinane derivatives of tetraoctyl[l 4]meta-cyclophane using ultrasonic irradiation. Boratocavitands were converted into the corresponding amine complexes with isobutylamine. © 2012 Pleiades Publishing, Ltd

Reactions of 2,4-diaryl 1,3,2,4-dithiadiphosphetane- 2,4-disulfides with resorcinol and 1,3-bis(2-hydroxyethoxy) benzene

Novel bisaryldithiophosphonic acids were obtained by the reactions of 2,4-diaryl 1,3,2,4-dithiadiphosphetane-2,4-disulfides with resorcinol and 1,3-bis(2-hydroxyethoxy)benzene. [image omitted]. © 2011 Taylor & Francis

Two-dimensional quantum interference contributions to the magnetoresistance of Nd{2-x}Ce{x}CuO{4-d} single crystals

The 2D weak localization effects at low temperatures T = (0.2-4.2)K have been investigated in nonsuperconducting sample Nd{1.88}Ce{0.12}CuO{4-d} and in the normal state of the superconducting sample Nd{1.82}Ce{0.18}CuO{4-d} for B>B_c2. The phase coherence time and the effective thickness $d$ of a conducting CuO_2 layer have been estimated by the fitting of 2D weak localization theory expressions to the magnetoresistivity data for the normal to plane and the in-plane magnetic fields.Comment: 5 pages, 4 postscript figure

Метастатический почечно-клеточный рак почки у ребенка 10 лет. Возможности таргетной терапии (клиническое наблюдение)

Renal cell carcinoma (RCC) is rare in children, its metastatic form is even rarer. At present there is no treatment protocol for children with RCC. This clinical observation presented the patient 10 year old with RCC metastases to the lungs. After radical surgery, after targeted sorafenib therapy the patient has a positive dynamics. At present his progression-free survival is 30 months.Почечно-клеточный рак (ПКР) редко встречается у детей, а его метастатическая форма еще реже. На настоящий момент не существует протоколов лечения для детей с ПКР, не изучены возможности современной таргетной терапии. В данной статье представлено клиническое наблюдение пациента 10 лет с ПКР и метастазами в легкие. После тотального удаления опухоли почки на фоне проведения таргетной терапии сорафенибом у пациента достигнута положительная динамика. В настоящий момент выживаемость без прогрессирования составляет 30 мес

New phosphorus dithioacids and their derivatives containing chiral centers and pharmacophoric groups

© 2016 Taylor & Francis Group, LLC.New phosphorus dithioacids, their ammonium salts and S-silyl and plumbyl derivatives containing asymmetric carbon atoms and pharmacophoric groupswere obtained by the reactions of tetraphosphorus decasulfide and 1,3,2,4-dithiadiphosphetane-2,4-disulfides with chiral natural terpenyl alcohols, diols, carboxylic acid esters, amino acids and monosaccharides as well as synthetic chiral amines and 1-phenylethanol. The biological activity of the ammonium salts and S-esters of phosphorus dithioacids were studied

New phosphorus dithioacids and their derivatives containing chiral centers and pharmacophoric groups

© 2016 Taylor & Francis Group, LLC.New phosphorus dithioacids, their ammonium salts and S-silyl and plumbyl derivatives containing asymmetric carbon atoms and pharmacophoric groupswere obtained by the reactions of tetraphosphorus decasulfide and 1,3,2,4-dithiadiphosphetane-2,4-disulfides with chiral natural terpenyl alcohols, diols, carboxylic acid esters, amino acids and monosaccharides as well as synthetic chiral amines and 1-phenylethanol. The biological activity of the ammonium salts and S-esters of phosphorus dithioacids were studied

Thiophosphorylation of calix[4]resorcinarenes with 2,4-diaryl-1,3-dithia- 2λ 5,4λ 5-diphosphetane 2,4-disulfides

Reactions of 2,4-diaryl-1,3-dithia-2λ 5, 4λ 5-diphosphetane 2,4-disulfides with tetraheptylcalix[4]- resorcinarene and octa-O-(2-hydroxyethyl)tetraoctylcalix[4]resorcinarene gave the corresponding octakis(aryldithiophosphonic acids). © Pleiades Publishing, Ltd., 2011