Millimeter polarisation of the protoplanetary nebula OH 231.8+4.2: A follow-up study with CARMA

In order to investigate the characteristics and influence of the magnetic field in evolved stars, we performed a follow-up investigation of our previous submillimeter analysis of the proto-planetary nebula (PPN) OH 231.8+4.2 (Sabin et al. 2014), this time at 1.3mm with the CARMA facility in polarisation mode for the purpose of a multi-scale analysis. OH 231.8+4.2 was observed at ~2.5" resolution and we detected polarised emission above the 3-sigma threshold (with a mean polarisation fraction of 3.5 %). The polarisation map indicates an overall organised magnetic field within the nebula. The main finding in this paper is the presence of a structure mostly compatible with an ordered toroidal component that is aligned with the PPN's dark lane. We also present some alternative magnetic field configuration to explain the structure observed. These data complete our previous SMA submillimeter data for a better investigation and understanding of the magnetic field structure in OH 231.8+4.2.Comment: 7 pages, 5 figures, 2 tables. Accepted for publication in MNRA

Submillimeter polarisation and magnetic field properties in the envelopes of proto-planetary nebulae CRL 618 and OH 231.8+4.2

We have carried out continuum and line polarisation observations of two Proto-planetary nebulae (PPNe), CRL 618 and OH 231.8+4.2, using the Submillimeter Array (SMA) in its compact configuration. The frequency range of observations, 330-345 GHz, includes the CO(J=3-2) line emission. CRL 618 and OH 231.8+4.2 show quadrupolar and bipolar optical lobes, respectively, surrounded by a dusty envelope reminiscent of their AGB phase. We report a detection of dust continuum polarised emission in both PPNe above 4 sigma but no molecular line polarisation detection above a 3 sigma limit. OH 231.8+4.2 is slightly more polarised on average than CRL 618 with a mean fractional polarisation of 4.3 and 0.3 per cent, respectively. This agrees with the previous finding that silicate dust shows higher polarisation than carbonaceous dust. In both objects, an anti-correlation between the fractional polarisation and the intensity is observed. Neither PPNe show a well defined toroidal equatorial field, rather the field is generally well aligned and organised along the polar direction. This is clearly seen in CRL 618 while in the case of OH 231.8+4.2, the geometry indicates an X-shaped structure coinciding overall with a dipole/polar configuration. However in the later case, the presence of a fragmented and weak toroidal field should not be discarded. Finally, in both PPNe, we observed that the well organised magnetic field is parallel with the major axis of the 12CO outflow. This alignment could indicate the presence of a magnetic outflow launching mechanism. Based on our new high resolution data we propose two scenarios to explain the evolution of the magnetic field in evolved stars.Comment: 11 pages, 8 figures and 1 table. Accepted for publication in the Monthly Notices of the Royal Astronomical Societ

The menopause transition in women living with HIV: current evidence and future avenues of research

As the life expectancy of people living with HIV improves as a result of antiretroviral therapy, increasing numbers of women living with HIV (WLHIV) are now reaching menopausal age. The menopause transition in WLHIV remains a relatively overlooked area in clinical HIV research. Whilst there is some evidence to suggest that WLHIV experience menopause at an earlier age and that they have more menopausal symptoms, there is no clear consensus in the literature around an impact of HIV infection on either timing or symptomatology of the menopause. Data are also conflicting on whether HIV-related factors such as HIV viral load and CD4 cell count have an impact on the menopause. Furthermore, menopausal symptoms in WLHIV are known to go under-recognised by both healthcare providers and women themselves. There is likely to be a burden of unmet health needs among WLHIV transitioning through the menopause, with significant gaps in the evidence base for their care. With this in mind, we have developed the PRIME study (Positive Transitions Through the Menopause). This mixed-methods observational study will explore, for the first time in the UK, the impact of the menopause on the health and wellbeing of 1500 ethnically diverse WLHIV. In establishing a cohort of women in their midlife and following them up longitudinally, we hope to develop a nuanced understanding of the gendered aspects of ageing and HIV, informing the provision of appropriate services for WLHIV to ensure that they are supported in maintaining optimal health and wellbeing as they get older

Treatment exhaustion of highly active antiretroviral therapy (HAART) among individuals infected with HIV in the United Kingdon: multicentre cohort study

Objectives: To investigate whether there is evidence that an increasing proportion of HIV infected patients is starting to experience increases in viral load and decreases in CD4 cell count that are consistent with exhaustion of available treatment options. Design: Multicentre cohort study. Setting: Six large HIV treatment centres in southeast England. Participants: All individuals seen for care between 1 January 1996 and 31 December 2002. Main outcome measures: Exposure to individual antiretroviral drugs and drug classes, CD4 count, plasma HIV RNA burden. Results: Information is available on 16 593 individuals (13 378 (80.6%) male patients, 10 340 (62.3%) infected via homosexual or bisexual sex, 4426 (26.7%) infected via heterosexual sex, median age 34 years). Overall, 10 207 of the 16 593 patients (61.5%) have been exposed to any antiretroviral therapy. This proportion increased from 41.2% of patients under follow up at the end of 1996 to 71.3% of those under follow up in 2002. The median CD4 count and HIV RNA burden of patients under follow up in each year changed from 270 cells/mm3 and 4.34 log10 copies/ml in 1996 to 408 cells/mm3 and 1.89 log10 copies/ml, respectively, in 2002. By 2002, 3060 (38%) of patients who had ever been treated with antiretroviral therapy had experienced all three main classes. Of these, around one quarter had evidence of “viral load failure” with all these three classes. Patients with three class failure were more likely to have an HIV RNA burden > 2.7 log10 copies/ml and a CD4 count < 200 cells/mm3. Conclusions: The proportion of individuals with HIV infection in the United Kingdom who have been treated has increased gradually over time. A substantial proportion of these patients seem to be in danger of exhausting their options for antiretroviral treatment. New drugs with low toxicity, which are not associated with cross resistance to existing drugs, are urgently needed for such patients