Il n'y a pas de hors (con)texte. Over boeken en recensies, schrijvers en lezers.

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Redactioneel

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In slow motion: cognitive and motor retardation during writing and drawing tasks in depressed inpatients

Contains fulltext : mmubn000001_242541895.pdf (publisher's version ) (Open Access)Promotores : F. Zitman, J.J.M. Van Hoof en W. Hulstijn217 p

Ongelijkheden en hun berekenheid.

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Pharmacological evaluation of π subunit-containing GABAa receptors

The GABAaR π subunit is the most recently identified, yet least studied GABAaR subunit which is found predominantly in the periphery where GABAergic function is still poorly understood. This thesis aimed to examine the functional assembly of the π subunit with other GABAaR subunits to form ion channels and the pharmacological properties that the π subunit conveys to the GABAaR. The π subunit was co-transfected with various other GABAaR subunits into Xenopus laevis oocytes to express GABAaRs and the effect of GABA, Zn2+ and etomidate were then examined. All αβπ receptors formed in this study were over 10-fold more sensitive to GABA and displayed a markedly greater increase in receptor efficacy in response to etomidate than their corresponding αβγ2L isoforms, and showed a reduced sensitivity to Zn2+ inhibition compared with their αβ counterparts. This study also presents electrophysiological evidence for the expression of β3π GABAaRs which are over 400-fold more sensitive to GABA, and have a reduced sensitivity to both Zn2+ inhibition and etomidate activation than homomeric β3 GABAaRs. This work thus demonstrates the functional expression of recombinant αβπ and β3π GABAARs which display a pharmacological profile that is distinct from αβγ2L, αβ and homomeric β3 GABAaRs

Even small grasses are smiling slightly.

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Psychomotorische vertraging bij depressie, gemeten met visuomotorische taken

Contains fulltext : 56630.pdf (publisher's version ) (Open Access)12 p