Effect of COVID-19 on the Wellbeing of Healthcare Professionals in Public Isolation Hospitals in Egypt

One of the most vulnerable groups severely hit by the COVID-19 pandemic has been the Healthcare Professionals (HCPs), especially the physicians, pharmacists, and nurses who work in public Isolation hospitals. The Egyptian medical syndicate declared the death of more than 600 physicians from February 2020 till January 2022. In the meantime, the Egyptian government has worked on different policies for relieving the negative effects of the pandemic on this vulnerable group; however, easing restrictions, no total lockdown implementation, and monitoring bureaucracy has negatively affected the wellbeing of those HCPs. The study aims to figure out recommended policies to protect HCPs’ wellbeing during the current pandemic and help us be better prepared for future upcoming pandemics that we may face. Based on seventeen in-depth semi-structured interviews with a purposive sample of HCPs, occupying different positions and located in different geographical areas in Egypt, the study assesses the extent of the effect of the COVID-19 pandemic as a mass causality incident on HCPs perceived sense of wellbeing and its different dimensions, as defined by the Centers for Disease Control and Prevention (CDC) and relating them to different needs levels according to the Maslow’s Hierarchy of needs for recommending policies depending on their needs. Findings show that although HCPs felt a sense of pride with their work and were somehow satisfied with their financial compensation, all other dimensions of their well-being were compromised, including the physical, psychological, emotional, social, developmental, and work domain-related aspects. Physical, social, and economic wellbeing aspects were deteriorated due to the lack of basic needs. Furthermore, Emotional, psychological, development and activity, and domain specific satisfaction aspects were worsened because of depletion of the psychological needs. Accordingly, life satisfaction, and engaging activities and work aspects collapsed after the diminishing of the self-fulfillment needs. Finally, Egyptian government has learned a lesson from the COVID-19 pandemic and started to prepare for management of the future pandemic that we may face by issuing a new law (Law no. 152/2021) for combating pandemics and epidemics, which covers the first step of the disaster cycle management

Vulnerable Older Populations without Special Health Care in Egypt: A need for Assessment & Reform / كبار السن الذين يفتقرون إلى الرعاية الصحية المتخصصة في مصر: متطلبات التقييم والإصلاح

The older population in Egypt needs a special healthcare system to fulfill its needs and expectations. Nowadays, the older people live longer than before due to the improvement of healthcare services. That leads to an increase in the number of older people and creates a pressure on resources especially with the limited resources in Egypt. Urbanization and the change in the Egyptian demographics is exacerbating the problem. Egypt now is becoming a nation of dignified older citizens that need additional care and special attention. A number of policies and reforms have already been discussed but never thoroughly analyzed. Some policies alternatives to the issue are discussed within this paper, and tangible solutions highlighted

Implication of endoplasmic reticulum stress and mitochondrial perturbations in remote liver injury after renal ischemia/reperfusion in rats: potential protective role of azilsartan

ABSTRACTObjectives: Distant liver injury is a complication of renal ischemia-reperfusion (I/R) injury, which imposes mortality and economic burden. This study aimed to elucidate the cross-talk of endoplasmic reticulum (ER) stress and mitochondrial perturbations in renal I/R-induced liver injury, and the potential hepatoprotective effect of azilsartan (AZL).Methods: Male albino Wister rats were pre-treated with AZL (3 mg/kg/day, PO) for 7 days then a bilateral renal I/R or sham procedure was performed. Activities of liver enzymes were assessed in plasma. The structure and ultra-structure of hepatocytes were assessed by light and electron microscopy. Markers of ER stress, mitochondrial biogenesis and apoptosis were analyzed in livers of rats.Results: Renal ischemic rats showed higher plasma levels of liver enzymes than sham-operated rats, coupled with histological and ultra-structural alterations in hepatocytes. Mechanistically, there was up-regulation of ER stress markers and suppression of mitochondrial biogenesis-related proteins and enhanced apoptosis in livers of renal ischemic rats. These abnormalities were almost abrogated by AZL pretreatment.Discussion: Our findings uncovered the involvement of mitochondrial perturbations, ER stress and apoptosis in liver injury following renal I/R, and suggested AZL as a preconditioning strategy to ameliorate remote liver injury in patients susceptible to renal I/R after adequate clinical testing

A comprehensive health effects assessment of the use of sanitizers and disinfectants during COVID-19 pandemic: a global survey

COVID-19 has affected all aspects of human life so far. From the outset of the pandemic, preventing the spread of COVID-19 through the observance of health protocols, especially the use of sanitizers and disinfectants was given more attention. Despite the effectiveness of disinfection chemicals in controlling and preventing COVID-19, there are critical concerns about their adverse effects on human health. This study aims to assess the health effects of sanitizers and disinfectants on a global scale. A total of 91,056 participants from 154 countries participated in this cross-sectional study. Information on the use of sanitizers and disinfectants and health was collected using an electronic questionnaire, which was translated into 26 languages via web-based platforms. The findings of this study suggest that detergents, alcohol-based substances, and chlorinated compounds emerged as the most prevalent chemical agents compared to other sanitizers and disinfectants examined. Most frequently reported health issues include skin effects and respiratory effects. The Chi-square test showed a significant association between chlorinated compounds (sodium hypochlorite and per-chlorine) with all possible health effects under investigation (p-value <0.001). Examination of risk factors based on multivariate logistic regression analysis showed that alcohols and alcohols-based materials were associated with skin effects (OR, 1.98; 95%CI, 1.87-2.09), per-chlorine was associated with eye effects (OR, 1.83; 95%CI, 1.74-1.93), and highly likely with itching and throat irritation (OR, 2.00; 95%CI, 1.90-2.11). Furthermore, formaldehyde was associated with a higher prevalence of neurological effects (OR, 2.17; 95%CI, 1.92-2.44). Furthermore, formaldehyde was associated with a higher prevalence of neurological effects (OR, 2.17; 95%CI, 1.92-2.44). The use of sodium hypochlorite and per-chlorine also had a high chance of having respiratory effects. The findings of the current study suggest that health authorities need to implement more awareness programs about the side effects of using sanitizers and disinfectants during viral epidemics especially when they are used or overused