Tuning Up Superoxide Dismutase Activity of Copper Complex of Salicylaldehyde Semicarbazone by Heterocyclic Bases Pyridine and N-methyl Imidazole

The copper(II) complexes of the Schiff base salicylaldehyde semicarbazone (SALSC) have been prepared and structurally characterized. The compound possesses a distorted square planar geometry where the metal atom lies slightly below the ligand donor atom plane and exhibits a longer Cu-Cl bond distance (2.226 Å). The superoxide dismutase activity of the compound can be synergistically enhanced by the addition of heterocyclic bases. © 2001 Elsevier Science B.V

Transition Metal Complexes of Phenanthrenequinone Thiosemicarbazone as Potential Anticancer Agents: Synthesis, Structure, Spectroscopy, Electrochemistry and in Vitro Anticancer Activity Against Human Breast Cancer Cell-line, T47D

The thiosemicarbazone derivative of 9,10-phenanthrenequinone, 1, and its metal complexes were synthesized. The X-ray crystal structure for 1 confirms the presence of the E tautomeric arrangement in this compound. Its copper complex shows 1:1 stoichiometry while nickel and cobalt compounds show 1:2 stoichiometry. The X-ray crystal structure of the nickel complex indicates two tridentate ligands coordinating in the thiolato form yielding an octahedral geometry for the \u27mer\u27 isomer. The copper complex exhibits maximum antiproliferative activity against human breast cancer cell-line, T47D probably due to inhibition of steroid binding to the cognative receptor or by preventing dimerization of the estrogen receptor