Oxidative stress in relation to lipid profiles in different stages of breast cancer

190-194The changes in the levels of MDA, nitrite, vit. E, lipids (total cholesterol and triglycerides) and lipoproteins (HDL and LDL cholesterol) were estimated among breast cancer patients, in relation to different clinical stages (stage I to IV). MDA and nitrite levels were increased in breast cancer patients, irrespective of clinical stage, as compared to controls (p<0.01). Their levels were also significantly elevated from stage III to stage IV (p<0.05). In contrast, vit. E levels were decreased in all stages, as compared to control group (p<0.05), the decrease was more pronounced in stage II and IV. Compared to controls, serum triglycerides were elevated in all patient groups (p<0.05); the maximum increase was in stage IV. HDL-cholesterol decreased in all stages, when compared with control group (p<0.05). These findings support the hypothesis that reactive oxygen and nitrogen species are increased in breast cancer, especially metastases and may cause consumption of vit. E

Endothelial dysfunction in patients with chronic perlodontitis and its improvement after initial periodontal therapy

Background: Recent epidemiological data suggested that there is a relationship between periodontal health and atherosclerotic coronary heart disease. Although hypothetical models were proposed, the exact mechanism of this association has not been clarified. The aim of this study is to investigate whether there is an endothelial dysfunction in patients with chronic periodontitis and, if present, whether recovery is possible with therapy

Infection and genotype relationship in multiple sclerosis: Do Chlamydophila pneumoniae and human herpes virus-6 infections together with APO E alleles have a role in the etiopathogenesis of multiple sclerosis?

Despite numerous studies in many laboratories over several years, the etiology of Multiple Sclerosis (MS) is still unknown. It was suggested that some infectious agents play a role in the etiology of MS. This study included 39 patients with MS, 10 patients with other neurological disorders (OND) and a control group of 42 healthy people. There was no significant difference between MS, OND and HC groups for Chlamydophila pneumoniae based on having past infection positivity (p > 0.05). Chronic C. pneumonia infection was detected in 8 cases with MS and 3 cases in the healthy control group, and no chronic chlamydia infection was detected in patients with OND. No significant difference was found among the three groups. Antibody titres at 1/50 and higher IgG were detected in 34(87.2%), 8(80%) and 30(71.4%) of the patients with MS, OND and the healthy control group, respectively. There was no statistically significiant difference among these groups. No C. pneumoniae and HHV-6 DNA was detected in CSF samples from the patients with MS and OND. There was no significant difference for the distribution of all APO E alleles for MS and healthy control groups. Moreover, no significant difference was found in the distribution of all APO E alleles for patients who had antibody titres for past infection with C. pneumonia and HHV-6 between MS and control group. In conclusion, our data suggested that there was no contribution from the association of the C. pneumoniea and HHV-6 infections to the etiopathogenesis of the MS and our results are in concurrance with two important meta-analysis studies reported in 2006, but large scale, prospective new trials are needed to clarify this subject as proposed in meta-analysis considirations

Association of red blood cell distribution width, systemic-immune-inflammation index and poor cardiovascular outcomes in patients with newly diagnosed hypertension

Background Red cell distribution width (RDW) and the systemic immune-inflammation index (SII) have been extensively studied as predictors of morbidity and mortality in several cardiovascular diseases. This prospective study aimed to investigate the relationship between long term major adverse cardiac events (MACEs) and simple hematological parameters in hypertensive patients. Methods The study included a total of 1202 patients with newly diagnosed HT. Of the patients, 662 (55.1%) were female and 540 (44.9%) were male, with a mean age of 53.0 ± 11.4 years. The primary endpoint of the study was long term MACE, including cardiac death, stroke, and myocardial infarction. This is the first study focusing on the association of SII with major adverse cardiovascular outcomes in patients with HT. Results Eighty-nine patients (8.7%) developed at least one MACE during a mean follow-up period of 82.2 ± 1.3 months. RDW (13.0 ± 0.9 vs. 13.5 ± 1.2%, p 13.1% (10.4 vs. 5%; p 465 x103/µL (11.8 vs. 3.1%; p < .001). The multivariate logistic regression analysis showed SII and RDW were independent predictors of MACEs. Conclusion The results of the study demonstrated that the RDW and SII were independent predictors of long-term cardiovascular events in hypertensive patients. These simple hematological parameters may be used as prognosticators of MACE in patients with newly diagnosed HT