Wireless Intraocular Pressure Sensing Using Microfabricated Minimally Invasive Flexible-Coiled LC Sensor Implant

This paper presents an implant-based wireless pressure sensing paradigm for long-range continuous intraocular pressure (IOP) monitoring of glaucoma patients. An implantable parylene-based pressure sensor has been developed, featuring an electrical LC-tank resonant circuit for passive wireless sensing without power consumption on the implanted site. The sensor is microfabricated with the use of parylene C (poly-chlorop- xylylene) to create a flexible coil substrate that can be folded for smaller physical form factor so as to achieve minimally invasive implantation, while stretched back without damage for enhanced inductive sensor–reader coil coupling so as to achieve strong sensing signal. A data-processed external readout method has also been developed to support pressure measurements. By incorporating the LC sensor and the readout method, wireless pressure sensing with 1-mmHg resolution in longer than 2-cm distance is successfully demonstrated. Other than extensive on-bench characterization, device testing through six-month chronic in vivo and acute ex vivo animal studies has verified the feasibility and efficacy of the sensor implant in the surgical aspect, including robust fixation and long-term biocompatibility in the intraocular environment. With meeting specifications of practical wireless pressure sensing and further reader development, this sensing methodology is promising for continuous, convenient, direct, and faithful IOP monitoring

Implantable parylene-based wireless intraocular pressure sensor

This paper presents a novel implantable, wireless, passive pressure sensor for ophthalmic applications. Two sensor designs incorporating surface-micromachined variable capacitor and variable capacitor/inductor are implemented to realize the pressure sensitive components. The sensor is monolithically microfabricated using parylene as a biocompatible structural material in a suitable form factor for increased ease of intraocular implantation. Pressure responses of the microsensor are characterized on-chip to demonstrate its high pressure sensitivity (> 7000 ppm/mmHg) with mmHg level resolution. An in vivo animal study verifies the biostability of the sensor implant in the intraocular environment after more than 150 days. This sensor will ultimately be implanted at the pars plana or iris of the eye to fulfill continuous intraocular pressure (IOP) monitoring in glaucoma patients

Microfabricated Implantable Parylene-Based Wireless Passive Intraocular Pressure Sensors

This paper presents an implantable parylene-based wireless pressure sensor for biomedical pressure sensing applications specifically designed for continuous intraocular pressure (IOP) monitoring in glaucoma patients. It has an electrical LC tank resonant circuit formed by an integrated capacitor and an inductor coil to facilitate passive wireless sensing using an external interrogating coil connected to a readout unit. Two surface-micromachined sensor designs incorporating variable capacitor and variable capacitor/inductor resonant circuits have been implemented to realize the pressure-sensitive components. The sensor is monolithically microfabricated by exploiting parylene as a biocompatible structural material in a suitable form factor for minimally invasive intraocular implantation. Pressure responses of the microsensor have been characterized to demonstrate its high pressure sensitivity (> 7000 ppm/mmHg) in both sensor designs, which confirms the feasibility of pressure sensing with smaller than 1 mmHg of resolution for practical biomedical applications. A six-month animal study verifies the in vivo bioefficacy and biostability of the implant in the intraocular environment with no surgical or postoperative complications. Preliminary ex vivo experimental results verify the IOP sensing feasibility of such device. This sensor will ultimately be implanted at the pars plana or on the iris of the eye to fulfill continuous, convenient, direct, and faithful IOP monitoring

Classifying Flexible Factors Using Fuzzy Concept

Abstract In Data Envelopment Analysis (DEA), it is assumed that the role of each factor is known as input or output. However, in some cases, there are shared factors that their input versus output status is not clearly known. These are flexible measures. In such cases, determining whether a factor is input or output is ambiguous. Therefore, using fuzzy concept seems to be necessary. In this paper, a two phase procedure is proposed to fuzzy classification of flexible measures. In the first phase, applying the existing classification methods, an orientation of flexible measures to aid in the definition of inputs and outputs is achieved. Through defining a membership function in second phase, the input versus output status of a factor is expressed by fuzzy notion. By the proposed method, the efficiency of a decision mating unit is defended by a membership degree. We illustrate the proposed model in a practical problem setting

Implantable micromechanical parylene-based pressure sensors for unpowered intraocular pressure sensing

This paper presents the first implantable, unpowered, parylene-based microelectromechanical system (MEMS) pressure sensor for intraocular pressure (IOP) sensing. From in situ mechanical deformation of the compliant spiral-tube structures, this sensor registers pressure variations without electrical or powered signal transduction of any kind. Micromachined high-aspect-ratio polymeric hollow tubes with different geometric layouts are implemented to obtain high-sensitivity pressure responses. An integrated device packaging method has been developed toward enabling minimally invasive suture-less needle-based implantation of the device. Both in vitro and ex vivo device characterizations have successfully demonstrated mmHg resolution of the pressure responses. In vivo animal experiments have also been conducted to verify the biocompatibility and functionality of the implant fixation method inside the eye. Using the proposed implantation scheme, the pressure response of the implant can be directly observed from outside the eye under visible light, with the goal of realizing convenient, direct and faithful IOP monitoring in glaucoma patients

A Novel Method on Customer Requirements Preferences Based on Common Set of Weight

Abstract: Quality function deployment (QFD) has been widely used as a multi-functional design tool to translate lingual voice of customer requirements (CRs) to a product's technical attributes in the design, development of products, process planning and production planning strategies. Even though QFD efforts have been extensively used, assessing information from participant experts is still difficult task in QFD planning. The proposed voting methodology uses common set of weight (CSW) method as a well known technique in data envelopment analysis (DEA) to aggregate each of the requirements expressed by customers and comparisons among the product produced by own company with competitive products. Using such flexible method can reduce cognitive burden of designers and engineers on the presence of lack of enough data and different points of voters' view. Based on the dominance concepts of DEA with incomplete information, we developed a systematic two phase method for prioritizing customers' requirements with a numerical example

Efficiency Evaluation in Two-stage Data Envelopment Analysis under a Fuzzy Environment: A Common-Weights Approach

The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.Data envelopment analysis (DEA) has been genuinely known as an impeccable technique for efficiency measurement. In practice, since many production systems such as broadcasting companies, banking and R&D activities include two processes connected in series, we have need of utilizing two-stage DEA models to identify the sources of inefficiency and explore in turn appropriate options for improving performance. The lack of the ability to generate the actual weights is not only an ongoing challenge in traditional DEA models, it can have serious repercussion for the contemporary DEA models (e.g., two-stage DEA). This paper presents a common-weights method for two-stage structures that allows us to consider equality of opportunity in a fuzzy environment when evaluating the system efficiency and the component process efficiencies. The proposed approach first seeks upper bounds on factor weights and then determines a set of common weights by a single linear programming problem. We illustrate the approach with a data set taken from the literature

Evaluating decision-making units under uncertainty using fuzzy multi-objective nonlinear programming

This paper proposes a new method to evaluate Decision Making Units (DMUs) under uncertainty using fuzzy Data Envelopment Analysis (DEA). In the proposed multi-objective nonlinear programming methodology both the objective functions and the constraints are considered fuzzy. The coefficients of the decision variables in the objective functions and in the constraints, as well as the DMUs under assessment are assumed to be fuzzy numbers with triangular membership functions. A comparison between the current fuzzy DEA models and the proposed method is illustrated by a numerical example

Implantable Flexible-Coiled Wireless Intraocular Pressure Sensor

This work presents an implantable wireless passive pressure sensor for long-range continuous intraocular pressure (IOP) monitoring of glaucoma patients. The sensor is microfabricated with use of parylene C (poly-chloro-p-xylylene) to create a flexible coil substrate that can be folded during implantation for suture-less minimally invasive surgery, while stretched back without damage for enhanced inductive sensor-reader coil coupling and the corresponding sensing signal. Extensive device characterizations including on-bench testing and in vivo and ex vivo animal studies verify the device feasibility in both engineering (1 mmHg pressure sensing accuracy and 2 cm sensing distance) and surgical (robust fixation to the iris and long-term biocompatibility in the intraocular environment) aspects, all meeting specifications for future practical implementation of such IOP sensing technology