Prevalence of bisphosphonate associated osteonecrosis of the jaws in multiple myeloma patients

<p>Abstract</p> <p>Background</p> <p>Bisphosphonate-associated osteonecrosis of the jaws (BP-ONJ) is an adverse effect of bisphosphonate treatment with varying reported incidence rates.</p> <p>Methods</p> <p>In two neighboring German cities, prevalence and additional factors of the development of BP-ONJ in multiple myeloma patients with bisphosphonates therapy were recorded using a retrospective (RS) and cross-sectional study (CSS) design. For the RS, all patients treated from Jan. 2000 - Feb. 2006 were contacted by letter. In the CSS, all patients treated from Oct. 2006 - Mar. 2008 had a physical and dental examination. Additionally, a literature review was conducted to evaluate all articles reporting on BP-ONJ prevalence. PubMed search terms were: bisphosphonat, diphosphonate, osteonecrosis, prevalence and incidence.</p> <p>Results</p> <p>In the RS, data from 81 of 161 patients could be obtained; four patients (4.9%) developed BP-ONJ. In the CSS, 16 of 78 patients (20.5%) developed BP-ONJ. All patients with BP-ONJ had received zoledronate; 12 of these had had additional bisphosphonates. All except one had an additional trigger factor (tooth extraction [n = 14], dental surgical procedure [n = 2], sharp mylohyoid ridge [n = 3]).</p> <p>Conclusion</p> <p>The prevalence of BP-ONJ may have been underestimated to date. The oral examination of all patients in this CSS might explain the higher prevalence, since even early asymptomatic stages of BP-ONJ and previously unnoticed symptomatic BP-ONJ were recorded. Since nearly all patients with BP-ONJ had an additional trigger factor, oral hygiene and dental care might help to reduce BP-ONJ incidence.</p

Bodenbelastung - Bodenschutz

SIGLECopy held by FIZ Karlsruhe; available from UB/TIB Hannover / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Overcoming the multiple testing problem when testing randomness

In this paper we propose a new method for overcoming the problem of adjusting for the multiple testing problem in the context of testing random number generators. We suggest it is to be used in conjunction with an existing method. More generally, the method can be useful in other situations where the multiple testing issue is encountered and the tests involved are not independent of each other, and their exact joint distribution is not readily available. The method makes use of the Mahalanobis distance and simulation. An example of its implementation is given using data from a roulette wheel

Arbeitsbeschaffungsmassnahmen

SIGLEBibliothek Weltwirtschaft Kiel C 134,733 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Energiebilanz des Saarlandes 1992

The energy balance presents extensive data on the primary energy balance, conversion balance and energy consumption of Saarland by energy sources, in the year under report. (orig.)Die Energiebilanz bietet in Tabellenform umfangreiches Zahlenmaterial zur Primaerenergiebilanz, Umwandlungsbilanz und zum Energieverbrauch des Saarlandes im Berichtsjahr, aufgeschluesselt nach Energietraegern. (orig.)Available from TIB Hannover / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Datenmanagement simulationsgestuetzter Entscheidungsprozesse am Beispiel der Fertigungssteuerung

SIGLEAvailable from TIB Hannover: RN 5668(72) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Zum Entwicklungsstand von Marketing-Informationssystemen in der Bundesrepublik Deutschland

Available from TIB Hannover: RN 5668(70) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Die berufliche Rehabilitation behinderter Personen Ergebnisse des Jahres 1987

UuStB Koeln(38)-890106988 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Macht der Banken Vortrag gehalten am 25. Juni 1987 an der Universitaet des Saarlandes

Bibliothek Weltwirtschaft Kiel A 169763 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman