Systems toxicology to advance human and environmental hazard assessment : A roadmap for advanced materials

Ideally, a Systems Toxicology (ST) approach is aimed at by (eco)toxicologists, i.e. a multidisciplinary area incorporating classical toxicological concepts with omics technologies, and the understanding of this through computational data sciences, chemistry, mathematics, and physics modelling. As outlined in sev-eral public reports (e.g. from ECHA-European Chemical Agency and EFSA-European Food Safety Authority), the way forward in the coming years in Europe is to integrate New Approach Methodologies (NAMs) (in-cluding omics technologies) into hazard and hence risk assessment (RA). Adverse Outcome Pathways (AOPs) describe a sequence of events in response to stress, from the molecular initiating event until an adverse outcome, which is relevant to RA or regulatory decision-making. AOPs are one of the facilitators to integrate mechanistic data into RA, but it is urgent to increase the inclusion of the vast mechanistic knowledge available, especially for the RA of novel smart and advanced materials (AdMa) with multi-functional characteristics. There are still many challenges to the routine usage of NAMs, e.g. omics-based information. Here, we summarise the current state of the art of ST, the benefits of human and environ-mental health cross knowledge and the available methods and output. The importance of this area has been highlighted for many years but is even more pressing in the context of AdMa. Furthermore, we outline the challenges and suggest recommendations for future implementation.(c) 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Peer reviewe

Measurement of the Low-Energy Antideuteron Inelastic Cross Section

In this Letter, we report the first measurement of the inelastic cross section for antideuteron-nucleus interactions at low particle momenta, covering a range of 0.3 = 17.4 and 31.8 is obtained. The measured inelastic cross section points to a possible excess with respect to the Glauber model parametrization used in GEANT4 in the lowest momentum interval of 0.3Peer reviewe

Measurement of nuclear effects on ψ(2S) production in p-Pb collisions at sNN−−−√ = 8.16 TeV

Inclusive psi(2S) production is measured in p-Pb collisions at the centre-of-mass energy per nucleon-nucleon pair root s(NN) = 8.16 TeV, using the ALICE detector at the CERN LHC. The production of psi(2S) is studied at forward (2.03<y(cms)Peer reviewe

J/psi production as a function of charged-particle multiplicity in p-Pb collisions at root s(NN)=8.16 TeV

Inclusive J/psi yields and average transverse momenta in p-Pb collisions at a center-of-mass energy per nucleon pairs root s(NN) = 8.16 TeV are measured as a function of the charged-particle pseudorapidity density with ALICE. The J/psi mesons are reconstructed at forward (2.03<y(cms)Peer reviewe

Constraining the Chiral Magnetic Effect with charge-dependent azimuthal correlations in Pb-Pb collisions at root s(NN)=2.76 and 5.02 TeV

Systematic studies of charge-dependent two- and three-particle correlations in Pb-Pb collisions at root s(NN) = 2.76 and 5.02 TeV used to probe the Chiral Magnetic Effect (CME) are presented. These measurements are performed for charged particles in the pseudorapidity (eta) and transverse momentum (p(T)) ranges |eta| and gamma(1, - 3) = . The results are used to estimate the contribution of background effects, associated with local charge conservation coupled to anisotropic flow modulations, to measurements of the CME. A blast-wave parametrisation that incorporates local charge conservation tuned to reproduce the centrality dependent background effects is not able to fully describe the measured gamma(1,1). Finally, the charge and centrality dependence of mixed-harmonics three-particle correlations, of the form gamma(1, 2) = , which are insensitive to the CME signal, verify again that background contributions dominate the measurement of gamma(1,1).Peer reviewe

Coherent photoproduction of rho(0) vector mesons in ultra-peripheral Pb-Pb collisions at root s(NN)=5.02 TeV

Cross sections for the coherent photoproduction of rho(0) vector mesons in ultra-peripheral Pb-Pb collisions at root s(NN) = 5.02 TeV are reported. The measurements, which rely on the pi(+)pi(-) decay channel, are presented in three regions of rapidity covering the range vertical bar y vertical bar <0.8. For each rapidity interval, cross sections are shown for different nuclear-breakup classes defined according to the presence of neutrons measured in the zero-degree calorimeters. The results are compared with predictions based on different models of nuclear shadowing. Finally, the observation of a coherently produced resonance-like structure with a mass around 1.7 GeV/c(2) and a width of about 140 MeV/c(2) is reported and compared with similar observations from other experiments.Peer reviewe

Elliptic Flow of Electrons from Beauty-Hadron Decays in Pb-Pb Collisions at root s(NN)=5.02 TeV

The elliptic flow of electrons from beauty hadron decays at midrapidity (vertical bar y vertical bar < 0.8) is measured in Pb-Pb collisions at root s(NN) = 5.02 TeV with the ALICE detector at the LHC. The azimuthal distribution of the particles produced in the collisions can be parametrized with a Fourier expansion, in which the second harmonic coefficient represents the elliptic flow, v(2). The v(2) coefficient of electrons from beauty hadron decays is measured for the first time in the transverse momentum (p(T)) range 1.3- 6 GeV/c in the centrality class 30%-50%. The measurement of electrons from beauty-hadron decays exploits their larger mean proper decay length c tau approximate to 500 mu m compared to that of charm hadrons and most of the other background sources. The v(2) of electrons from beauty hadron decays at midrapidity is found to be positive with a significance of 3.75 sigma. The results provide insights into the degree of thermalization of beauty quarks in the medium. A model assuming full thermalization of beauty quarks is strongly disfavored by the measurement at high p(T), but is in agreement with the results at low p(T). Transport models including substantial interactions of beauty quarks with an expanding strongly interacting medium describe the measurement within uncertainties.Peer reviewe

Measurement of isolated photon-hadron correlations in root S-NN=5.02 TeV pp and p-Pb collisions

This paper presents isolated photon-hadron correlations using pp and p-Pb data collected by the ALICE detector at the LHC. For photons with vertical bar eta vertical bar <0.67 and 12 <p(T) <40 GeV/c, the associated yield of charged particles in the range vertical bar eta vertical bar <0.80 and 0.5 <p(T) <10 GeV/c is presented. These momenta are much lower than previous measurements at the LHC. No significant difference between pp and p-Pb is observed, with PYTHIA 8.2 describing both data sets within uncertainties. This measurement constrains nuclear effects on the parton fragmentation in p-Pb collisions, and provides a benchmark for future studies of Pb-Pb collisions.Peer reviewe

Lambda K femtoscopy in Pb-Pb collisions at root s(NN)=2.76 TeV

The first measurements of the scattering parameters of Lambda K pairs in all three charge combinations (Lambda K+, Lambda K-, and Lambda K-S(0)) are presented. The results are achieved through a femtoscopic analysis of Lambda K correlations in Pb-Pb collisions at root s(NN) = 2.76 TeV recorded by ALICE at the Large Hadron Collider. The femtoscopic correlations result from strong final-state interactions and are fit with a parametrization allowing for both the characterization of the pair emission source and the measurement of the scattering parameters for the particle pairs. Extensive studies with the THERMINATOR 2 event generator provide a good description of the nonfemtoscopic background, which results mainly from collective effects, with unprecedented precision. Furthermore, together with HIJING simulations, this model is used to account for contributions from residual correlations induced by feed-down from particle decays. The extracted scattering parameters indicate that the strong force is repulsive in the Lambda K+ interaction and attractive in the Lambda K- interaction. The data hint that the Lambda K-S(0) interaction is attractive; however, the uncertainty of the result does not permit such a decisive conclusion. The results suggest an effect arising either from different quark-antiquark interactions between the pairs (s (s) over bar in Lambda K+ and u (u) over bar in Lambda K-) or from different net strangeness for each system (S = 0 for Lambda K+, and S = -2 for Lambda K-). Finally, the Lambda K systems exhibit source radii larger than expected from extrapolation from identical particle femtoscopic studies. This effect is interpreted as resulting from the separation in space-time of the single-particle Lambda and K source distributions.Peer reviewe

Production of light-flavor hadrons in pp collisions at root s=7 and root s=13 Tev

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