Development of a hybrid AHP and Dempster-Shafer theory of evidence for project risk assessment problem

In this paper, a new hybrid AHP and Dempster-Shafer Theory of Evidence is presented for solving the problem of choosing the best project among a list of available alternatives while uncertain risk factors are taken into account. The aim is to minimize overall risks. For this purpose, four groups of risk factors, including Properties, Operational and Technological, Financial, Strategic risk factors, are considered. Then using an L2 4 Taguchi method, several experiments with various dimensions have been designed and solved by the proposed algorithm. The outcomes are then analyzed using the Validating Index (VI), Reduced Risk Indicator (R.R.I%), and Solving time. The findings indicated that, compared to the classic AHP, the results of the proposed hybrid method were different in most cases due to uncertainty of risk factors. It was observed that the method could be safely used for selecting project problems in real industries

Seasonal variations of respiratory viruses detected from children with respiratory tract infections in Riyadh, Saudi Arabia

ARTIs have a huge impact in health systems in which 20–30% of all hospital admissions and 30–60% of practitioner visits are related to respiratory tract infections. The aim of this study is to determine the prevalence, age distribution, and seasonal variation of respiratory viruses. This study was descriptive retrospective study in which all patients 14 years of age and below who presented with signs and symptoms of ARTIs between January 2013 and December 2014 and had respiratory specimen tested by direct immunofluorescence assays for viruses identification were included in the study. During that period, a total of 4611 patients who presented with ARTIs from January 2013 to December 2014 were investigated, viruses were detected in 1115 (24%). RSV was associated with 97.4% of the total viral pathogens. Viruses were detected throughout all the two years with a peak in winter; Dec (n: 265), Jan (n: 418), Feb (n: 218), and Mar (n: 109). Viral pathogens are very important cause of ARTIs in our region. RSV was the most common virus detected with the highest detection rate in children who are two years old and below. A multi-center surveillance with more sensitive detection methods like PCR may help to provide a comprehensive understanding of virus distribution in our area, which may contribute implant an effective prevention approach for each virus. Keywords: Pediatrics, Infectious diseases, Respiratory infections, Respiratory syncytial virus, Saudi Arabi

Disseminated Infection Complicating Intravesical BCG Instillation for the Treatment of Superficial Transitional Cell Carcinoma of the Bladder

Background Intravesical instillation of Bacillus Calmette–Guérin (BCG) remains a first-line treatment for superficial transitional cell carcinoma of the bladder. Although its use is relatively safe, severe complications such as granulomatous hepatitis, osteomyelitis, pneumonitis, and sepsis occur in few patients. Complications of intravesical instillation of BCG can be local or systemic, with early or late presentation. Case Presentation Here, we report an 88-year-old man who developed fever, rigors, and episodes of syncope following fourth intravesical BCG instillation for the treatment of superficial transitional cell carcinoma of the bladder. Pancytopenia, disseminated intravascular coagulation, ground glass appearance on computerized tomography of the chest scan in addition to multiple bone marrow granulomas, suggested the diagnosis of disseminated BCG infection. All these features recovered on antituberculosis treatment. Conclusion Our case study highlights the importance of early recognition and prompt treatment of patients with disseminated BCG infection following intravesical instillation. Although isolation of mycobacterium is desirable to make the diagnosis, it is not unusual to have negative smears and cultures and this should not be used to dismiss the possibility of BCG infection

A New Hybrid AHP and Dempster—Shafer Theory of Evidence Method for Project Risk Assessment Problem

In this paper, a new hybrid AHP and Dempster—Shafer theory of evidence is presented for solving the problem of choosing the best project among a list of available alternatives while uncertain risk factors are taken into account. The aim is to minimize overall risks. For this purpose, a three-phase framework is proposed. In the first phase, quantitative research was conducted to identify the risk factors that can influence a project. Then, a hybrid PCA-agglomerative unsupervised machine learning algorithm is proposed to classify the projects in terms of Properties, Operational and Technological, Financial, and Strategic risk factors. In the third step, a hybrid AHP and Dempster—Shafer theory of evidence is presented to select the best alternative with the lowest level of overall risks. As a result, four groups of risk factors, including Properties, Operational and Technological, Financial, and Strategic risk factors, are considered. Afterward, using an L2^4 Taguchi method, several experiments with various dimensions have been designed which are then solved by the proposed algorithm. The outcomes are then analyzed using the Validating Index, Reduced Risk Indicator, and Solving Time. The findings indicated that, compared to classic AHP, the results of the proposed hybrid method were different in most cases due to uncertainty of risk factors. It was observed that the method could be safely used for selecting project problems in real industries

2. Central line associated blood stream infection in a pediatric cardiac intensive care unit: Incidence, risk factors, and outcome

Clinical research. Presentation Type: Oral presentation. Introduction: Central Line Associated Blood Stream Infection (CLABSI) is a serious infection associated with 28,000 deaths and expenses from $296 million to$2.3 billion yearly. There is scarcity of data on CLABSI in pediatric cardiac intensive care units (PCICU). The aim of the study is to describe the risk factors, causative organisms and outcome of CLABSI in a PCICU. Methodology: The study was retrospective cohort in which all charts of patients admitted to the PCICU from January 2012 to September 2012 were reviewed. Patients who had central line were followed to see if they develop CLABSI from the central line insertion date until discharge. Results: Two hundred and sixty-one patients were included in the study. There were 2275 central line days and 19 CLABSI episodes (8.35 CLABSIs per 1000 central line days). Most common causative pathogens isolated were gram negative bacteria (N = 10, 50%) with Klebsiella pneumoniae and coagulase negative Staphylococcus were the leading causative organisms (N = 4, 20% each). Patients who developed the infection had a longer stay at the PCICU with a mean of 27.1 days compared to 8.20 days for non CLABSI Patients (P 7 days were independent risk factors. Conclusion: CLABSI increased the length of PCICU stay and mortality, yet it has recognizable associated risk factors. Infection control measures should be carefully implemented with special attention given to patients with CLABSI risk factors

Molecular Detection, Serotyping, and Antibiotic Resistance of Shiga Toxigenic Escherichia coli Isolated from She-Camels and In-Contact Humans in Egypt

This study aims to determine the prevalence of STEC in she-camels suffering from mastitis in semi-arid regions by using traditional culture methods and then confirming it with Serological and molecular techniques in milk samples, camel feces, as well as human stool samples for human contacts. In addition, an antibiotic susceptibility profile for these isolates was investigation. Mastitic milk samples were taken after California Mastitis Test (CMT) procedure, and fecal samples were taken from she-camels and human stool samples, then cultured using traditional methods to isolate Escherichiacoli. These isolates were initially classified serologically, then an mPCR (Multiplex PCR) was used to determine virulence genes. Finally, both camel and human isolates were tested for antibiotic susceptibility. Out of a total of 180 she-camels, 34 (18.9%) were mastitic (8.3% clinical and 10.6% sub-clinical mastitis), where it was higher in camels bred with other animals. The total presence of E. coli was 21.9, 13.9, and 33.7% in milk, camel feces, and human stool, respectively, whereas the occurrence of STEC from the total E. coli isolates were 36, 16, and 31.4% for milk, camel feces, and stool, respectively. Among the camel isolates, stx1 was the most frequently detected virulence gene, while hlyA was not detected. The most detected virulence gene in human isolates was stx2 (45.5%), followed by stx1. Camel STEC showed resistance to Oxytetracycline only, while human STEC showed multiple drug resistance to Amoxicillin, Gentamycin, and Clindamycin with 81.8, 72.7, and 63.6%, respectively. Breeding camels in semi-arid areas separately from other animals may reduce the risk of infection with some bacteria, including E. coli; in contrast, mixed breeding with other animals contributes a significant risk factor for STEC emergence in camels

Hypoxia-Inducible Factor 1 and Preeclampsia: A New Perspective

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Phytochemical Analysis and Understanding the Antioxidant and Anticancer Properties of Methanol Extract from Litsea glutinosa: In Vitro and In Vivo Studies

International audienceLitsea glutinosa (L. glutinosa) is considered an evidence-based medicinal plant for the treatment of cancer, the leading cause of death worldwide. In our study, the in vitro antioxidant and in vivo anticancer properties of an essential ethno-medicinal plant, L. glutinosa, were examined using non-toxic doses and a phytochemical analysis was executed using gas-chromatography–mass-spectrometry. The in vitro antioxidant study of the L. glutinosa methanolic extract (LGBME) revealed a concentration-dependent antioxidant property. The bark extract showed promising antioxidant effects in the 2,2-diphenyl-1-picryl-hydrazyl (DPPH) assay. The strongest antioxidant activity was demonstrated at the maximum concentration (50 µg/mL). The IC50 values of the LGBME and BHT were 5.51 and 5.01 µg/mL, respectively. At the same concentration, the total antioxidant capacity of the LGBME was 0.161 µg/mL and the ferric reducing antioxidant power assay result of the LGBME was 1.783 µg/mL. In the cytotoxicity study, the LD50 of the LGBME and gallic acid were 24.93 µg/mL and 7.23 µg/mL, respectively. In the in vivo anticancer-activity studies, the LGBME, particularly at a dose of 150 mg/kg/bw, showed significant cell-growth inhibition, decreased tumor weight, increased mean survival rate, and upregulated the reduced hematological parameters in EAC (Ehrlich’s ascites carcinoma)-induced Swiss albino mice. The highest cell-growth inhibition, 85.76%, was observed with the dose of 150 mg/kg/bw. Furthermore, the upregulation of pro-apoptotic genes (p53, Bax) and the downregulation of anti-apoptotic Bcl-2 were observed. In conclusion, LGBME extract has several bioactive phytoconstituents, which confirms the antioxidant and anticancer properties of L. glutinosa

Epidemiological Trends of Acute Chemical Poisoning among Children over a Recent Three-Year Period in Saudi Arabia

Acute intoxication from chemicals is a major medical emergency that can result in illness and mortality. This retrospective study aims to evaluate acute chemical poisoning incidents among children in Saudi Arabia from 2019 to 2021. A total of 3009 children were recorded as being chemically intoxicated. The SPSS/PC statistics package was used for the statistical analysis. The acute chemical poisoning incidents that occurred in the age groups were <1 year: 237 (7.8%), 1–5 years: 2301 (76.4%), 6–12 years: 214 (7.1%), and 13–19 years: 257 (8.5%). The mean rate of acute chemical poisoning in the northern region was 40.1%. The most common poisonous agents were organic solvents (20.4%) and disinfection agents (22.7%). Interestingly, there is a significant relationship between the different types of acute chemical poisoning and various factors, including gender, age, the location where acute chemical intoxication occurred, the type of exposure, and whether these were intentional or unintentional events. The data suggest that the northern region of Saudi Arabia has had the highest number of recorded incidents of acute chemical poisoning over the last three years (2019–2021). Individuals between 1–5 years old were the worst hit. Organic solvents and detergents were to blame for the acute unintentional chemical poisonings that took place in homes. Therefore, educating the public about chemical poisoning and reducing children’s exposure to toxic chemicals requires educational programs, which may help to reduce chemical poisoning occurrence