Berg Denge Ölçeği’nin Türkçe versiyonunun inmeli hastalarda geçerlilik ve güvenilirliği

Objective: The aim of the study was to assess reliability, validity and responsiveness of the Berg Balance Scale (BBS) which had been translated to the Turkish language and made transcultural adaptation. Materials and Methods: In this study, we included stroke patients who past the 3-week acute post-stroke period and were planned for rehabilitation. Exclusion criteria included having no ability of understanding the commands and presence of major perceptual and cognitive disorders. The patients were assessed on admission and three months after discharge. Beside BBS scores, Functional Independence Measure-motor scores (FIM-MS), Rivermead Mobility Index (RMI) scores and Brunnsrom recovery stages were evaluated. Internal consistency in reliability study was assessed using Cronbach-α, convergent validity study was assessed by estimation of Spearman correlation coefficient of FIM-MS and RMI scores. Responsiveness was detected by assessing the effect size, and counting the standardized response mean. Results: Sixty-four patients (34 female, 30 male) with a mean age of 63.6±10.46 years were included. Duration of stroke was 35.9±16.4 days. The right side was affected in 34 patients (53%), and the left side in 30 patients (47%). There were significant improvements in all parameters at three month follow-up compared to admission period (p<0.0001). In reliability study, Cronbach-α for total BBS was found to be 0.96. In correlation for validation study, there was positive correlations between BBS and FIM-MS (r=0.69, p<0.0001), and BBS and RMI (r=077, p<0.0001). Since the effect size of BBS was found to be 1.90, and standardized response mean value was found to be 1.85, the BBS was found to have a good level of responsiveness. Conclusion: According to the results of this study, the Turkish version of the BBS is valid, reliable, and responsive in stroke patients in the three month acute post-stroke period. © Turkish Journal of Physical Medicine and Rehabilitation, Published by Galenos Publishing

The coexistence of cystic fibrosis and celiac disease in a child: Case report Bir çocukta kistik fibrozis ve çölyak hastaliǧi birlikteliǧi

© Copyright 2016 by Türkiye Klinikleri.Cystic fibrosis (CF) is an autosomal recessive disorder characterized by recurrent pulmonary infections, fat malabsorption and growth retardation. The patients are generally treated pancreatic enzyme replacement therapy (PERT) and enteral nutrition support. Optimal growth could not achieved in some patients despite the adequate treatment. These patients must be evaluated for other malabsorption syndromes such as celiac disease (CD). We presented a case to pay attention the presence of CD in a patient with CF who had growth retardation and gastrointestinal symptoms despite adequate PERT and nutritional support

The Diagnostic Significance of Bowel Wall Thickening for Inflammatory Bowel Disease

Copyright © 2016 by Tür kiye Klinikleri.Objective:We aimed to investigate the diagnostic significance of bowel wall thickening (BWT) in abdominal computed tomography (ACT) imaging in combination with clinical and laboratory parameters for inflammatory bowel disease (IBD). Material and Methods: The study included the patients admitted to our clinic with both chronic abdominal symptoms and performed colonoscopy and ACT since 2008. Age and gender of the patients, hematological parameters [hemoglobin level, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), albumin, and platelet count], site of BWT (terminal ileum, entire colon and recto-sigmoid), accompanying pathologies [lymphadenopathy (LAP), fistula] and final diagnoses were recorded from the file reports. Subjects with BWT were divided into subgroups, with or without IBD, and compared. Results: 109 (54.1% female, mean age 10.44±4.14 years) children were included in the study. BWT was determined in 31 (28.4%) patients (67.7% female, mean±SD age 12.36±3.68). BWT was located at the terminal ileum in 11 (35.5%), at the colon in 9 (29.0%) and at the recto-sigmoid region in 11 (35.5%) patients. There was pathologic LAP in nine (29.0%), internal fistula in 1 (3.2%) and intraabdominal fluid in 2 (6.4%) patients. Ultimately, 15 (48.4%) patients were diagnosed as having IBD, 6 (19.4%) non-specific colitis and 4 (12.9%) with other diseases. No etiological factor was found with BWT in 6 (19.4%) patients. Significant difference was found in ESR (p=0.02) and platelet count (p=0.0001) in patients with both BWT and IBD (n=15) compared with the other patients (n=16). Conclusions: Inflammatory bowel disease must be in differential diagnoses in children with chronic abdominal symptoms and BWT combined with high ESR and platelet count and advanced evaluations performed for the diagnoses

The diagnostic significance of bowel wall thickening for inflammatory bowel disease Barsak Duvar Kalinlaşmasinin İnflamatuar Barsak Hastaliǧi İcin Tanisal Onemi

Copyright © 2016 by Tür kiye Klinikleri.Objective:We aimed to investigate the diagnostic significance of bowel wall thickening (BWT) in abdominal computed tomography (ACT) imaging in combination with clinical and laboratory parameters for inflammatory bowel disease (IBD). Material and Methods: The study included the patients admitted to our clinic with both chronic abdominal symptoms and performed colonoscopy and ACT since 2008. Age and gender of the patients, hematological parameters [hemoglobin level, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), albumin, and platelet count], site of BWT (terminal ileum, entire colon and recto-sigmoid), accompanying pathologies [lymphadenopathy (LAP), fistula] and final diagnoses were recorded from the file reports. Subjects with BWT were divided into subgroups, with or without IBD, and compared. Results: 109 (54.1% female, mean age 10.44±4.14 years) children were included in the study. BWT was determined in 31 (28.4%) patients (67.7% female, mean±SD age 12.36±3.68). BWT was located at the terminal ileum in 11 (35.5%), at the colon in 9 (29.0%) and at the recto-sigmoid region in 11 (35.5%) patients. There was pathologic LAP in nine (29.0%), internal fistula in 1 (3.2%) and intraabdominal fluid in 2 (6.4%) patients. Ultimately, 15 (48.4%) patients were diagnosed as having IBD, 6 (19.4%) non-specific colitis and 4 (12.9%) with other diseases. No etiological factor was found with BWT in 6 (19.4%) patients. Significant difference was found in ESR (p=0.02) and platelet count (p=0.0001) in patients with both BWT and IBD (n=15) compared with the other patients (n=16). Conclusions: Inflammatory bowel disease must be in differential diagnoses in children with chronic abdominal symptoms and BWT combined with high ESR and platelet count and advanced evaluations performed for the diagnoses

The Coexistence of Cystic Fibrosis and Celiac Disease in A Child: Case Report

© Copyright 2016 by Türkiye Klinikleri.Cystic fibrosis (CF) is an autosomal recessive disorder characterized by recurrent pulmonary infections, fat malabsorption and growth retardation. The patients are generally treated pancreatic enzyme replacement therapy (PERT) and enteral nutrition support. Optimal growth could not achieved in some patients despite the adequate treatment. These patients must be evaluated for other malabsorption syndromes such as celiac disease (CD). We presented a case to pay attention the presence of CD in a patient with CF who had growth retardation and gastrointestinal symptoms despite adequate PERT and nutritional support

In vitro and in vivo activities of Haplophyllum myrtifolium against Leishmania tropica

This study aimed to evaluate the in vitro and in vivo leishmanicidal activity of an endemic Turkish plant and compare its efficacy with a reference drug. In addition to the in vitro activities of the ethanol, acidified and alkaloid extracts and furoquinoline alkaloids skimmianine and γ-fagarine, in vivo antileishmanial activitiy of the acidified extract of Haplophyllum myrtifolium Boiss. (Rutaceae) were investigated against Leishmania tropica (L. tropica), a causative agent of cutaneous leishmaniasis. All the extracts and pure compounds showed in vitro inhibitory activity against the promastigotes of. L. tropica. The in vitro 50% inhibitory concentrations of γ-fagarine, acidified extract, ethanol extract, skimmianine and alkaloid extract against promastigotes were determined as 8.7, 9.4, 10.9, 25.7 and 25.8 µg/ml respectively. In vivo results of Haplophyllum myrtifolium acidified extract showed that this plant has a limited effect on decreasing the lesion size of experimental mice infected with Leishmania tropica. To the best of our knowledge, this is the first time both the in vitro and in vivo antileishmanial activity of Haplophyllum mrytifolium have been reported in the same research

In vitro and in vivo activities of Haplophyllum myrtifolium against Leishmania tropica

WOS: 000251225500010PubMed ID: 18080680This study aimed to evaluate the in vitro and in vivo leishmanicidal activity of an endemic Turkish plant and compare its efficacy with a reference drug. In addition to the in vitro activities of the ethanol, acidified and alkaloid extracts and furoquinoline alkaloids skimmianine and gamma-fagarine, in vivo antileishmanial activitiy of the acidified extract of Haplophyllum myrtifolium Boiss. (Rutaceae) were investigated against Leishmania tropica (L. tropica), a causative agent of cutaneous leishmaniasis. All the extracts and pure compounds showed in vitro inhibitory activity against the promastigotes of. L. tropica. The in vitro 50% inhibitory concentrations of gamma-fagarine, acidified extract, ethanol extract, skimmianine and alkaloid extract against promastigotes were determined as 8.7, 9.4, 10.9, 25.7 and 25.8 mu g/ml respectively. In vivo results of Haplophyllum myrtifolium acidified extract showed that this plant has a limited effect on decreasing the lesion size of experimental mice infected with Leishmania tropica. To the best of our knowledge, this is the first time both the in vitro and in vivo antileishmanial activity of Haplophyllum mrytifolium have been reported in the same research

Neurological manifestations of pediatric acute covid infections: A single center experience

© 2021 The Author(s) [2021]. Published by Oxford University Press. All rights reserved. For permissions, please email: [email protected]: Coronavirus disease 2019 (COVID-19) usually leads to a mild infectious disease course in children, while serious complications may occur in conjunction with both acute infection and neurological symptoms, which have been predominantly reported in adults. The neurological complications in these patients vary based on patient age and underlying comorbidities. Data on clinical features, particularly neurological features, and prognostic factors in children and adolescents are limited. This study provides a concise overview of neurological complications in pediatric COVID-19 cases. Materials and methods: The retrospective study reviewed medical records of all patients who were admitted to our hospital and were diagnosed with COVID-19 by real-time reverse-transcription polymerase-chain-reaction (RT-PCR) assay between 11 March 2020 and 30 January 2021. Patients with a positive PCR result were categorized into two groups: outpatient departments patients and inpatient departments (IPD). Results: Of the 2530 children who underwent RT-PCR during the study period, 382 (8.6%) were confirmed as COVID-19 positive, comprising 188 (49.2%) girls and 194 (50.8%) boys with a mean age of 7.14±5.84 (range, 0-17) years. Neurological complications that required hospitalization were present in 34 (8.9%) patients, including seizure (52.9%), headache (38.2%), dizziness (11.1%) and meningoencephalitis (5.8%). Conclusion: The results indicated that neurological manifestations are not rare in children suffering from COVID-19. Seizures, headaches, dizziness, anosmia, ageusia and meningoencephalitis are major neurological manifestations during acute COVID-19 disease. Although seizures were the most common cause of hospitalization in IPD patients, the frequency of meningoencephalitis was quite high. Seizures were observed as febrile seizures for children under 6 years of age and afebrile seizures for those over 6 years of age. Febrile seizure accounted for half of all seizure children